Výsledky vyhledávání - "M.A. Villaronga"

'The big sleep: Elucidating the sequence of events in the first hours of death to determine the postmortem interval'

Autor: Douglas H. Ubelaker, Paula Núñez Martínez, Sara C. Zapico, Juana M. García-Pedrero, Sofía T. Menéndez, M.A. Villaronga

Publikováno v: Science & Justice. 59:418-424

Recent developments on postmortem interval estimation (PMI) take an advantage of the autolysis process, pointing out to the analysis of the expression of apoptosis and autophagy genes towards this purpose. Oxidative stress plays a role in this signal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1408a7df5f8ac6c37244a01d6a8ff4f6
https://doi.org/10.1016/j.scijus.2019.03.001

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HERG1 potassium channel expression in potentially malignant disorders of the oral mucosa and prognostic relevance in oral squamous cell carcinoma

Autor: Juana M. García-Pedrero, Saúl Álvarez-Teijeiro, Juan P. Rodrigo, Laura Suárez-Fernández, Tania Rodríguez-Santamarta, Álvaro Fernández-Valle, M.A. Villaronga, de Vicente Jc, Paloma Lequerica-Fernández

Publikováno v: Head & Neck. 38:1672-1678

Background HERG1 potassium channel plays a critical role in the cell proliferation. Methods HERG1 protein expression was analyzed by immunohistochemistry (IHC) in 62 patients with oral leukoplakias and 100 patients with oral squamous cell carcinomas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e9c095a9fa735efcf153ec9b3a2e39b5
https://doi.org/10.1002/hed.24493

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Analysis of Invasive Activity of CAF Spheroids into Three Dimensional (3D) Collagen Matrices

Autor: Francisco Hermida-Prado, Marta Garzón-Arango, Juana M. García-Pedrero, Saúl Álvarez Teijeiro, Victoria Sanz-Moreno, M.A. Villaronga

Publikováno v: Methods in Molecular Biology ISBN: 9781493975945

Tumor growth and progression is the result of a complex process controlled not only by malignant cancer cells but also by the surrounding tumor microenvironment (TME). Cancer associated fibroblasts (CAFs), the most abundant cellular component of TME,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ad61ae5efd536b22509fa5359ba040c0
https://doi.org/10.1007/978-1-4939-7595-2_14

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PO-477 A novel role for nanog as an early cancer risk marker in patients with laryngeal precancerous lesions

Autor: Juan P. Rodrigo, Isabel Vilaseca, Juana M. García-Pedrero, Aurora Astudillo, Rocío Granda-Díaz, Francisco Hermida-Prado, M.A. Villaronga, Miquel Quer, Sofía T. Menéndez

Publikováno v: ESMO Open. 3:A416-A417

Introduction NANOG is a transcription factor involved in embryonic pluripotency maintenance. It has also been shown that it has a mitogenic function in adult epithelial tissues. Overexpression of NANOG in mice causes hyperplasia, increased proliferat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ecc9aacd918367bdd6c17b141be8a337
https://doi.org/10.1136/esmoopen-2018-eacr25.980

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Frequent aberrant expression of the human ether à go-go (hEAG1) potassium channel in head and neck cancer: pathobiological mechanisms and clinical implications

Autor: Juana M. García-Pedrero, Dario Garcia-Carracedo, Saúl Álvarez-Teijeiro, Rocío G. Urdinguio, Carlos Suárez, Mario F. Fraga, Cristina G. Viloria, Sofía T. Menéndez, Luis A. Pardo, Juan P. Rodrigo, M.A. Villaronga

Publikováno v: Journal of Molecular Medicine. 90:1173-1184

Compelling evidence indicates that the human ether-à-go-go voltage-gated potassium channels (hEAG1) may represent new valuable membrane therapeutic targets and diagnostic/prognostic biomarkers in various cancers. This study is the first to investiga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c95e1ad52e2e007105019a5ee3994e60
https://doi.org/10.1007/s00109-012-0893-0

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PO-079 Dysregulation of miR-196B in head and neck cancers leads to pleiotropic effects in the tumour cells and CAFs

Autor: J.M. Garcia-Pedrero, J.C. Vicente, Maria Pilar Fernandez, C. Lawrie, Saúl Álvarez-Teijeiro, L. Manterola, L. Villalain, J.P. Rodrigo, Sofía T. Menéndez, M.A. Villaronga

Publikováno v: ESMO Open. 3:A257

Introduction The miR-196 family members have been found dysregulated in different cancers. Therefore, they have been proposed as promising biomarkers and therapeutic targets. This study is the first to investigate the role of miR-196b in the developm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c16ed79e83488038bfc39dece72d1078
https://doi.org/10.1136/esmoopen-2018-eacr25.607

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PO-490 Expression of cortactin and focal adhesion kinase in early stages of laryngeal tumorigenesis and clinical application for cancer risk-stratification

Autor: Juana M. García-Pedrero, Francisco Hermida-Prado, Isabel Vilaseca, M.A. Villaronga, M. Sanchez Canteli, Juan P. Rodrigo, Rocío Granda-Díaz, Miquel Quer, Sofía T. Menéndez, Eva Allonca

Publikováno v: ESMO Open. 3:A422

Introduction Cortactin (CTTN) and the Focal Adhesion Kinase (FAK) are two major candidate genes to respectively drive 11q13- and 8q24-associated aggressive behaviour in various cancers. Recent evidence uncovered their clinical relevance in early stag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e4bb54984479772b98474589e5fcb45a
https://doi.org/10.1136/esmoopen-2018-eacr25.992

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PO-478 Prognostic significance of E-cadherin and beta-catenin expression in HPV-negative oropharyngeal squamous cell carcinomas

Autor: R. Granda, Eva Allonca, M.A. Villaronga, Francisco Hermida-Prado, N. Del Rio-Ibisate, Saúl Álvarez-Teijeiro, Juana M. García-Pedrero, Juan P. Rodrigo

Publikováno v: ESMO Open. 3:A417

Introduction Mounting evidence show an increasing prevalence of human papillomavirus (HPV) in head and neck squamous cell carcinomas (HNSCC), particularly in oropharyngeal squamous cell carcinoma (OPSCC), whereas tobacco-associated tumours arising in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3e89a168caee5f53cc1d75ada049ff7a
https://doi.org/10.1136/esmoopen-2018-eacr25.981

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