Zobrazeno 1 - 10 of 28 pro vyhledávání: '"M.A. Rivera-Bermudez"'
1
LXR modulation blocks prostaglandin E 2 production and matrix degradation in cartilage and alleviates pain in a rat osteoarthritis model
Autor: Yihe Wang, Julio Tejada, Ning Li, Sunil Nagpal, Carl R. Flannery, M.A. Rivera-Bermudez, Zhiyong Yang, Elisabeth A. Morris, Ken C. N. Chang, S.S. Glasson, Edward R. Lavallie, Lisa A. Collins-Racie, Mei Zhang
Publikováno v: Proceedings of the National Academy of Sciences. 107:3734-3739
Osteoarthritis (OA), the most common arthritic condition in humans, is characterized by the progressive degeneration of articular cartilage accompanied by chronic joint pain. Inflammatory mediators, such as cytokines and prostaglandin E 2 (PGE 2 ) th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0d3e21ddd8aa3bc13ec7579bcb50018
https://doi.org/10.1073/pnas.0911377107
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2
Prevention of cartilage degeneration in a rat model of osteoarthritis by intraarticular treatment with recombinant lubricin
Autor: Adam Root, Christopher John Corcoran, Alison M. Bendele, Richard Zollner, Elisabeth A. Morris, S.S. Glasson, Jason P. Gleghorn, M.A. Rivera-Bermudez, Tracey Blanchet, Lawrence J. Bonassar, Carl R. Flannery, Aled R. C. Jones
Publikováno v: Arthritis & Rheumatism. 60:840-847
Objective Lubricin, also referred to as superficial zone protein and PRG4, is a synovial glycoprotein that supplies a friction-resistant, antiadhesive coating to the surfaces of articular cartilage, thereby protecting against arthritis-associated tis
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac000660e21ad6263655b05017d0abfb
https://doi.org/10.1002/art.24304
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3
Serine protease HTRA1 antagonizes transforming growth factor-β signaling by cleaving its receptors and loss of HTRA1 in vivo enhances bone formation
Autor: Weilan Zeng, X. Jian Li, Mark Ryan, Carl R. Flannery, David Dai, M.A. Rivera-Bermudez, Zhiyong Yang, Angela Chamberland, Julie R. Graham, Qingcong Lin
Publikováno v: PLoS ONE, Vol 8, Iss 9, p e74094 (2013)
PLoS ONE
HTRA1 is a member of the High Temperature Requirement (HTRA1) family of serine proteases, which play a role in several biological and pathological processes. In part, HTRA1 regulation occurs by inhibiting the TGF-β signaling pathway, however the mec
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a495466133ac77f4286b2cf56cbfb17a
http://europepmc.org/articles/PMC3770692?pdf=render
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4
Disposition of Human Recombinant Lubricin in Naive Rats and in a Rat Model of Post-traumatic Arthritis After Intra-articular or Intravenous Administration
Autor: Xin Xu, Yulia Vugmeyster, Richard Zollner, Jian Li, Qin Wang, Carl R. Flannery, M.A. Rivera-Bermudez, Daren Daugusta, John M. Harrold
We have recently demonstrated that intra-articular (IA) administration of human recombinant lubricin, LUB:1, significantly inhibited cartilage degeneration and pain in the rat meniscal tear model of post-traumatic arthritis. In this report, we show t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd66289a236251be0203e08433c0b1d8
https://europepmc.org/articles/PMC3291179/
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6
Elevated aggrecanase activity in a rat model of joint injury is attenuated by an aggrecanase specific inhibitor
Autor: M.A. Rivera-Bermudez, Staffan Larsson, Weilan Zeng, Carl R. Flannery, Priya S. Chockalingam, S.S. Glasson, W. Sun, Katy E. Georgiadis, L.S. Lohmander, D.R. Dufield, Elisabeth A. Morris
Publikováno v: Osteoarthritis and cartilage. 19(3)
Summary Objective To evaluate aggrecanase activity after traumatic knee injury in a rat model by measuring the level of aggrecanase-generated Ala-Arg-Gly-aggrecan (ARG-aggrecan) fragments in synovial fluid, and compare with ARG-aggrecan release into
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::705dd180fa0b28fbdb6c51490f1d4857
https://pubmed.ncbi.nlm.nih.gov/21491648
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