Zobrazeno 1 - 10
of 49
pro vyhledávání: '"M.A. Pest"'
Autor:
Ling Qin, Frank Beier, Jae Wook Jeong, Melina Rodrigues Bellini, Manuela Miranda-Rodrigues, M.A. Pest
Publikováno v:
Physiology and Pharmacology Publications
Arthritis Research & Therapy, Vol 22, Iss 1, Pp 1-13 (2020)
Arthritis Research & Therapy
Arthritis Research & Therapy, Vol 22, Iss 1, Pp 1-13 (2020)
Arthritis Research & Therapy
Background Osteoarthritis (OA) is the most common form of arthritis and characterized by degeneration of the articular cartilage. Mitogen-inducible gene 6 (Mig-6) has been identified as a negative regulator of the epidermal growth factor receptor (EG
BackgroundMitogen-inducible gene 6 (Mig-6) is a tumour suppressor gene that is also associated with the development of osteoarthritis (OA)-like disorder. Recent evidence from our lab and others showed that cartilage-specific Mig-6 knockout (KO) mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21ed029c19bfd6c30f6aeb0fa370bfcf
BackgroundOsteoarthritis (OA) is the most common form of arthritis and characterized by degeneration of articular cartilage. Mitogen-inducible gene 6 (Mig-6) has been identified as a negative regulator of the Epidermal Growth Factor Receptor (EGFR).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::403147fcd85ca210cc32d9116bf17e69
Akademický článek
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Publikováno v:
Osteoarthritis and Cartilage. 27:S93-S94
Publikováno v:
Arthritis & Rheumatology. 67:2691-2701
Objective Transforming growth factor α (TGFα) is increased in osteoarthritic (OA) cartilage in rats and humans and modifies chondrocyte phenotype. CCL2 is increased in OA cartilage and stimulates proteoglycan loss. This study was undertaken to test
Autor:
Matthew R. McCann, Kim L. Beaucage, M.A. Pest, Meg P. Kamphuis, Frank Beier, A. Ratneswaran, Cheryle A. Séguin, Gurkeet Lalli, Garth B. Backler, Jimin Lee, Ziana Esmail, David W. Holdsworth, John S. Mort, Priya Patel, Michael Barbalinardo, S. Jeffrey Dixon
Publikováno v:
Arthritis & Rheumatology. 67:2164-2175
Objective High-frequency, low-amplitude whole-body vibration (WBV) is being used to treat a range of musculoskeletal disorders; however, there is surprisingly limited knowledge regarding its effect(s) on joint tissues. This study was undertaken to ex
Publikováno v:
Bone and Joint Institute
Current Opinion in Rheumatology
Current Opinion in Rheumatology
Purpose of review Despite the tremendous individual suffering and socioeconomic burden caused by osteoarthritis, there are currently no effective disease-modifying treatment options. This is in part because of our incomplete understanding of osteoart
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db5de6c657e7d7bb1f9dbec9bd3acdf8
https://ir.lib.uwo.ca/boneandjointpub/280
https://ir.lib.uwo.ca/boneandjointpub/280
Publikováno v:
Arthritis & Rheumatology. 66:2816-2827
Objective Mitogen-inducible gene 6 (MIG-6) regulates epidermal growth factor receptor (EGFR) signaling in synovial joint tissues. Whole-body knockout of the Mig6 gene in mice has been shown to induce osteoarthritis and joint degeneration. To evaluate
Publikováno v:
Osteoarthritis and Cartilage. 26:S79-S80