Downregulation of G protein-coupled receptor kinase 2 levels enhances cardiac insulin sensitivity and switches on cardioprotective gene expression patterns

Autor: Sonia Fernández-Veledo, Elisa Lucas, María Jurado-Pueyo, Ehre Gao, Javier Díez, Federico Mayor, Cristina Murga, Juan José Lazcano, Javier Gómez-Ambrosi, M.A. Fortuño, Gema Frühbeck, Luis Jesús Jiménez-Borreguero, Walter J. Koch, Rocio Vila-Bedmar

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Biblos-e Archivo. Repositorio Institucional de la UAM
Biochimica et Biophysica Acta-Molecular Basis of Disease
Repositori Institucional de la Universitat Rovira i Virgili
Universitat Rovira i virgili (URV)

© 2014 Elsevier B.V. G protein-coupled receptor kinase 2 (GRK2) has recently emerged as a negative modulator of insulin signaling. GRK2 downregulation improves insulin sensitivity and prevents systemic insulin resistance. Cardiac GRK2 levels are inc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16546e7a9877265a6f4b20ec4a9a9fce
https://doi.org/10.1016/j.bbadis.2014.09.004

Cardiotrophin-1 is expressed in adipose tissue and upregulated in the metabolic syndrome

Autor: M.A. Fortuño, Javier Díez, Patricia Restituto, Immaculada Colina, Antonio Bazán, Nerea Varo, Cristina Natal

Publikováno v: American Journal of Physiology-Endocrinology and Metabolism. 294:E52-E60

Adipose tissue is a target for cardiotrophin-1 (CT-1), a cytokine member of the IL-6 family of cytokines that is involved in cardiac growth and dysfunction. However, it is unknown whether adipocytes are a source of CT-1 and whether CT-1 is overexpres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3f8385123b82b49571e8d0c26a52603
https://doi.org/10.1152/ajpendo.00506.2007

Oxidative Stress in Arterial Hypertension

Autor: Javier Díez, Gorka San José, María U. Moreno, Francisco J. Beaumont, Guillermo Zalba, Ana Fortuño, M.A. Fortuño

Publikováno v: Hypertension. 38:1395-1399

Increased vascular reactive oxygen species production, especially superoxide anion, contributes significantly in the functional and structural alterations present in hypertension. An enhanced superoxide production causes a diminished NO bioavailabili

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2097dc7d3a40d2ea883555f6023d64e3
https://doi.org/10.1161/hy1201.099611

Marcadores bioquímicos de fibrosis miocárdica en las enfermedades cardíacas

Autor: G. Zalba Goñi, B. López Salazar, J. Beaumont Ezcurra, S. Ravassa Albéniz, M.A. Fortuño Cebamanos, G. San José Enériz, A. Fortuño Gil, J. Díez Martínez, U. Moreno Zulategui, A. González Miqueo

Publikováno v: Hipertensión y Riesgo Vascular. 18:383-388

Se sabe que en el ventriculo izquierdo de animales y de humanos con distintos tipos de cardiopatia el contenido de fibras de colageno esta aumentado. La fibrosis miocardica es el resultado de la acumulacion de fibras de colageno de tipo I y de tipo I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9ef0bef464009ef45d6d1ae044e884ef
https://doi.org/10.1016/s1889-1837(01)71189-0

Aldosterone and the cardiovascular system: a dangerous association

Autor: Beatriz Martín-Fernández, Ernesto Martínez, Natalia de las Heras, María Miana, M.A. Fortuño, Vicente Lahera, Natalia López-Andrés, Victoria Cachofeiro

Publikováno v: Hormone Molecular Biology and Clinical Investigation. 4

Initial studies have focussed on the actions of aldosterone in renal electrolyte handling and, as a consequence, blood pressure control. More recently, attention has primarily been focussed on its actions on the heart and vascular system, where it is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8008f860913b58b40b308dc8e91e5e7
https://doi.org/10.1515/hmbci.2010.057