Morpho-functional analysis of patient-derived xenografts reveals differential impact of gastric cancer and chemotherapy on the tumor ecosystem, affecting immune check point, metabolism, and sarcopenia

Autor: A. Venkatasamy, E. Guerin, W. Reichardt, V. Devignot, M. P. Chenard, L. Miguet, B. Romain, A. C. Jung, I. Gross, C. Gaiddon, G. Mellitzer

Publikováno v: Gastric Cancer. 26:220-233

Objectives Gastric cancer (GC) is an aggressive disease due to late diagnosis resulting from the lack of easy diagnostic tools, resistances toward immunotherapy (due to low PD-L1 expression), or chemotherapies (due to p53 mutations), and comorbidity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6d5748aefcc76bb709a70bec7121cbaf
https://doi.org/10.1007/s10120-022-01359-w

Carcinoma ductal in situ

Autor: M Lodi, M.-P. Chenard, C Mathelin, D. Antoni, S Molière

Publikováno v: EMC - Ginecología-Obstetricia. 57:1-12

Resumen El carcinoma ductal in situ (CDIS) se define como una proliferacion de celulas malignas en los conductos galactoforos, sin que atraviesen la membrana basal. El CDIS representa alrededor el 10-15% del conjunto de los canceres mamarios. Su trat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0b26a2c2d56b74695662975a4cd77101
https://doi.org/10.1016/s1283-081x(20)44698-3

Involvement of Neutrophils in Metastatic Evolution of Pancreatic Neuroendocrine Tumors

Autor: François Severac, Philippe Baltzinger, Xiaoping Su, Guillaume Davidson, Jean-Emmanuel Kurtz, Véronique Debien, Patrick Pessaux, Irwin Davidson, Pietro Addeo, Gabriel G. Malouf, M. P. Chenard, Alessio Imperiale, Philippe Bachellier, Bernard Goichot

Publikováno v: Cancers
Cancers, MDPI, 2021, 13 (11), pp.2771. ⟨10.3390/cancers13112771⟩
Cancers, Vol 13, Iss 2771, p 2771 (2021)
Volume 13
Issue 11
Cancers, 2021, 13 (11), pp.2771. ⟨10.3390/cancers13112771⟩

Well-differentiated pancreatic neuroendocrine tumors (pNET) have an unpredictable natural history. The identification of both blood and tumor immune features associated with patients’ outcomes remains limited. Herein, we evaluated the best prognost

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f58f7c82326614ddc5f633fe93e504b0
http://europepmc.org/articles/PMC8199674

Matrix Metalloproteinase-11 Promotes Early Mouse Mammary Gland Tumor Growth through Metabolic Reprogramming and Increased IGF1/AKT/FoxO1 Signaling Pathway, Enhanced ER Stress and Alteration in Mitochondrial UPR

Autor: M. P. Chenard, Hassiba Outilaft, Catherine Tomasetto, Fabien Alpy, Bing Tan, Izzie Jacques Namer, Corinne Wendling, A. Ercument Cicek, Nassim Dali-Youcef, Amélie Jaulin, Caroline Bund

Publikováno v: Cancers
Cancers, 2020, 12 (9), pp.2357. ⟨10.3390/cancers12092357⟩
Volume 12
Issue 9
Cansers
Cancers, MDPI, 2020, 12 (9), pp.2357. ⟨10.3390/cancers12092357⟩
Cancers, Vol 12, Iss 2357, p 2357 (2020)

International audience; Matrix metalloproteinase 11 (MMP11) is an extracellular proteolytic enzyme belonging to the matrix metalloproteinase (MMP11) family. These proteases are involved in extracellular matrix (ECM) remodeling and activation of laten

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3a4880036cd23e370e2c45c6453bb8e
https://hal.science/hal-03415184/document

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.