Zobrazeno 1 - 10
of 77
pro vyhledávání: '"M.-C. Coene"'
Autor:
J. Van Dun, Lieve Dillen, M. D. W. G. Krekels, A. Verhoeven, W. Wouters, C. Van Hove, M.-C. Coene, W. Cools
Publikováno v:
British Journal of Cancer
Cytochrome P450-dependent oxidation is a pathway for all-trans-retinoic acid (all-trans-RA) catabolism. Induction of this catabolic pathway was studied in MCF-7 breast cancer cells. MCF-7 cells showed low constitutive all-trans-RA catabolism. Concent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa47f770aaac1d6cb1e03690c847a03d
http://europepmc.org/articles/PMC2222791
http://europepmc.org/articles/PMC2222791
Autor:
I. Roels, Patrick Marichal, H. Vanden Bossche, D. Bellens, L. Le Jeune, M.-C. Coene, P. A. J. Janssen, G. Willemsens, J. Gorrens
Publikováno v:
Mycoses. 33:335-352
The N-1-substituted triazole antifungal, saperconazole, is a potent inhibitor of ergosterol synthesis in Candida albicans, Aspergillus fumigatus and Trichophyton mentagrophytes. Fifty % inhibition is already achieved at nanomolar concentrations. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e3a221eb9c4cefd8fd0a62f986d493a
https://doi.org/10.1111/myc.1990.33.7-8.335
https://doi.org/10.1111/myc.1990.33.7-8.335
Autor:
A. Raeymaekers, G. Vanden Bussche, Gerard Charles Sanz, E. Snoeck, R. De Coster, J. Bruynseels, W. Wouters, H. Vanden Bossche, M.-C. Coene, P. Van Rooy, G. Willemsens, Eddy Jean Edgard Freyne, P. A. J. Janssen
Publikováno v:
The Prostate. 16:345-357
R 75251, a new imidazole derivative, inhibited the conversion of androgens to estrogens, of progestins to androstenedione and testosterone, and of 11-deoxycorticosterone to corticosterone in human placenta microsomes, subcellular fraction of rat test
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e30ace7e98bb9f93cd53d728f40bbbaa
https://doi.org/10.1002/pros.2990160409
https://doi.org/10.1002/pros.2990160409
Autor:
Joop M. A. van Gerven, Adam F. Cohen, Aernout D. van Haarst, J. Burggraaf, Gerben A. E. van't Klooster, Joop C. van Oene, Rik C. Schoemaker, M.-C. Coene
Publikováno v:
Clinical pharmacology and therapeutics. 64(5)
Objective Recently a few cases of long QT syndrome were reported during treatment with cisapride. In most of these cases, risk factors for cardiac arrhythmias or pharmacologic interactions might have been involved, and the role of cisapride remained
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::125c3ae3cd9153b685d05861fa52540f
https://pubmed.ncbi.nlm.nih.gov/9834046
https://pubmed.ncbi.nlm.nih.gov/9834046
Autor:
Wouters Walter Boudewijn Leopo, M. D. W. G. Krekels, Robert Van Ginckel, Jacco Zimmerman, M.-C. Coene, Carl Van Hove, W. Cools, Boudewijn Janssens
Publikováno v:
The Prostate. 29(1)
We studied the enzymatic characteristics of the oxidative catabolism of retinoic acid (RA) and its inhibition by liarozole-fumarate in homogenates of rat Dunning R3327G prostate tumors. Homogenates of rat liver were used as reference material. Both t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19f236982f6af0b5d667292b7bee862f
https://pubmed.ncbi.nlm.nih.gov/8685053
https://pubmed.ncbi.nlm.nih.gov/8685053
Autor:
Frans C. S. Ramaekers, R. Van Ginckel, G. Daneels, M. Borgers, M.-C. Coene, J.A. Schalken, M. Moeremans, G. Smets, J. Van Wauwe, R. De Coster
Publikováno v:
The Prostate. 27(3)
Liarozole showed antitumoral activity in the Dunning AT-6sq, an androgen-independent rat prostate carcinoma. To investigate its potential mechanism of action, the effects of the drug doses (ranging from 3.75 to 80 mg/kg b.i.d.) on endogenous plasma a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fc8bc4bd2fdf9c9cae260ad3a25c2d7
https://pubmed.ncbi.nlm.nih.gov/7567691
https://pubmed.ncbi.nlm.nih.gov/7567691
Publikováno v:
Mycoses. 38(3-4)
Summary. Two Candida krusei isolates were used to compare the effects of fluconazole, ketoconazole and itraconazole on growth and ergosterol synthesis, and to measure intracellular drug contents. Fifty per cent inhibition (IC50) of growth was achieve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa86bc211bcceb2d7ffcb54cf09f3b55
https://pubmed.ncbi.nlm.nih.gov/7477085
https://pubmed.ncbi.nlm.nih.gov/7477085
Autor:
M.-C. Coene, G. Van Nyen, L. Le Jeune, C. Van Hove, J. Goossens, W. Lauwers, J. Van Wauwe, W. Cools
Publikováno v:
Biochemical pharmacology. 47(4)
The metabolism of 4-keto-all- trans -retinoic-acid (4-keto-RA), a biologically active oxygenated metabolite of all- trans -retinoic (RA), has been examined. In vitro , incubation of [ 14 C]4-keto-RA with hamster liver microsomes in the presence of NA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6b12ca9334dc2e30ad85f9fff3003c8
https://pubmed.ncbi.nlm.nih.gov/8129749
https://pubmed.ncbi.nlm.nih.gov/8129749
Publikováno v:
Antimicrobial agents and chemotherapy. 37(10)
As in other pathogenic fungi, the major sterol synthesized by Cryptococcus neoformans var. neoformans is ergosterol. This yeast also shares with most pathogenic fungi a susceptibility of its cytochrome P-450-dependent ergosterol synthesis to nanomola
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c52a38ae7ee676909f8739c2dd5a6aad
https://pubmed.ncbi.nlm.nih.gov/8257130
https://pubmed.ncbi.nlm.nih.gov/8257130
Publikováno v:
Antimicrobial agents and chemotherapy. 36(12)
A Candida (Torulopsis) glabrata strain (B57149) became resistant to fluconazole after a patient carrying the organism was treated with the drug at 400 mg once daily for 9 days. Growth of the pretreatment isolate (B57148) was inhibited by 50% with 0.6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc3bb8918e6f8ee80c716e4ef9430d55
https://pubmed.ncbi.nlm.nih.gov/1482129
https://pubmed.ncbi.nlm.nih.gov/1482129