Phase II Trial of Dolastatin-10, a Novel Anti-Tubulin Agent, in Metastatic Soft Tissue Sarcomas

Autor: M. von Mehren, S. P. Balcerzak, A. S. Kraft, J. H. Edmonson, S. H. Okuno, M. Davey, S. Mclaughlin, M. T. Beard, A. Rogatko

Publikováno v: Sarcoma, Vol 8, Iss 4, Pp 107-111 (2004)

Patients:Soft tissue sarcomas are uncommon malignancies with few therapeutic options for recurrent or metastatic disease. Dolastatin-10 (Dol-10) is a pentapeptide anti-microtubule agent that binds to tubulin sites distinct from vinca alkaloids. Based

Externí odkaz: https://doaj.org/article/eaa4b43d1e9c4b16a8543458dd5dbe3a

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Level of evidence used in recommendations by the National Comprehensive Cancer Network (NCCN) guidelines beyond Food and Drug Administration approvals

Autor: Robert W. Carlson, Al B. Benson, L. Million, David S. Ettinger, Razelle Kurzrock, Lisa A. Gurski, Shaji Kumar, M. von Mehren, Steve Horwitz

Publikováno v: Annals of Oncology

Background A previous analysis of 113 National Comprehensive Cancer Network® (NCCN®) recommendations reported that NCCN frequently recommends beyond Food and Drug Administration (FDA)-approved indications (44 off-label recommendations) and claimed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b84d8032f1a879eafbdc5f45ef424146
https://doi.org/10.1093/annonc/mdz232

Diagnosis and management of tropomyosin receptor kinase (TRK) fusion sarcomas:expert recommendations from the World Sarcoma Network

Autor: Piotr Rutkowski, David Thomas, Robert G. Maki, Rick L. Haas, Shreyaskumar Patel, Patrick Schöffski, Y-K. Kang, M. von Mehren, K. Sundby Hall, Nadia Hindi, Akira Kawai, Eva Wardelmann, A. J. Lazar, Jonathan A. Fletcher, A. P. Dei Tos, Marta Sbaraglia, Jonathan C. Trent, Kjetil Boye, Roberta Maestro, Anthony D. Wagner, Hans Gelderblom, César Serrano, Inga-Marie Schaefer, Claudia Valverde, Alessandro Gronchi, Bodil Bjerkehagen, Frédérique Penault-Llorca, C. Premanand Raut, Yoichi Naito, W.T.A. van der Graaf, George D. Demetri, Matías Chacón, John Zalcberg, Judith V.M.G. Bovée, William D. Tap, Akmal Safwat, C. R. Antonescu, Suzanne George, Li Shen, Ian Judson, Jayesh Desai, Javier Martin, J.-Y. Blay, Silvia Stacchiotti, A. Le Cesne, Robin L. Jones, Heikki Joensuu, Peter Hohenberger

Publikováno v: Demetri, G D, Antonescu, C R, Bjerkehagen, B, Bovée, J V M G, Boye, K, Chacón, M, Dei Tos, A P, Desai, J, Fletcher, J A, Gelderblom, H, George, S, Gronchi, A, Haas, R L, Hindi, N, Hohenberger, P, Joensuu, H, Jones, R L, Judson, I, Kang, Y K, Kawai, A, Lazar, A J, Le Cesne, A, Maestro, R, Maki, R G, Martín, J, Patel, S, Penault-Llorca, F, Premanand Raut, C, Rutkowski, P, Safwat, A, Sbaraglia, M, Schaefer, I M, Shen, L, Serrano, C, Schöffski, P, Stacchiotti, S, Sundby Hall, K, Tap, W D, Thomas, D M, Trent, J, Valverde, C, van der Graaf, W T A, von Mehren, M, Wagner, A, Wardelmann, E, Naito, Y, Zalcberg, J & Blay, J Y 2020, ' Diagnosis and management of tropomyosin receptor kinase (TRK) fusion sarcomas : expert recommendations from the World Sarcoma Network ', Annals of Oncology, vol. 31, no. 11, pp. 1506-1517 . https://doi.org/10.1016/j.annonc.2020.08.2232
Annals of Oncology
Annals of Oncology, Elsevier, 2020, 31 (11), pp.1506-1517. ⟨10.1016/j.annonc.2020.08.2232⟩
Annals of oncology : official journal of the European Society for Medical Oncology
Annals of Oncology, 31, 1506-1517
Scientia
Annals of Oncology, 31, 11, pp. 1506-1517
Annals of Oncology, 31(11), 1506-1517. ELSEVIER
Digital.CSIC. Repositorio Institucional del CSIC
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© 2020 The Author(s).
Sarcomas are a heterogeneous group of malignancies with mesenchymal lineage differentiation. The discovery of neurotrophic tyrosine receptor kinase (NTRK) gene fusions as tissue-agnostic oncogenic drivers has led to new pe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adc6da2272a91c82fcd7dcaf0bec00d6
https://pure.au.dk/portal/da/publications/diagnosis-and-management-of-tropomyosin-receptor-kinase-trk-fusion-sarcomas(d4cdbeec-e95a-46e5-9266-9b370d76c19f).html