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pro vyhledávání: '"M. van der Waals"'
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Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0205536 (2018)
BACKGROUND:Aldehyde dehydrogenase 1A1 (ALDH1A1) encodes an enzyme that oxidizes aldehydes to their corresponding carboxylic acids. In colorectal cancer ALDH1A1 marks cancer stem cells and plays putative roles in tumor progression and drug resistance.
Externí odkaz:
https://doaj.org/article/8910c936e7774bef9bb97dbfb96f2818
Autor:
Esther Kuiper, Martin Braster, M. van der Waals, Bernd W. Brandt, Willi Gottstein, Jan Gerritse, Rick Helmus, John R. Parsons, Lucas Fillinger, Hauke Smidt, Chrats Melkonian, Douwe Molenaar, Siavash Atashgahi, R. J. M. Van Spanning, Brett G. Olivier, U. Nunes da Rocha
A key question in microbial ecology is what the driving forces behind the persistence of large biodiversity in natural environments are. We studied a microbial community with more than 100 different types of species which evolved in a 15-years old bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca204004f1d270cf134ac8ccf1f27843
https://doi.org/10.1101/2020.07.17.208124
https://doi.org/10.1101/2020.07.17.208124
Autor:
Inge Ubink, Lizet M. van der Waals, Kateryna Veremiyenko, Paul J. van Diest, Kari Trumpi, Susanne J Schenning-van Schelven, Inne H.M. Borel Rinkes, Jennifer M.J. Jongen, Sjoerd G. Elias, Onno Kranenburg, Anne Trinh, Jamila Laoukili
Publikováno v:
The American Journal of Pathology. 188:2369-2377
High levels of oxidative stress in disseminated colorectal cancer tumor cells may form a therapeutically exploitable vulnerability. However, it is unclear whether oxidative stress and damage persist in metastases. Therefore, we analyzed markers of ox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41cecc918037875f2b5b693d999f1abb
https://doi.org/10.1016/j.ajpath.2018.06.008
https://doi.org/10.1016/j.ajpath.2018.06.008
Differential anti-tumour effects of MTH1 inhibitors in patient-derived 3D colorectal cancer cultures
Autor:
Danielle A.E. Raats, Onno Kranenburg, Jamila Laoukili, Lizet M. van der Waals, Inne H.M. Borel Rinkes, Jennifer M.J. Jongen
Publikováno v:
Scientific Reports, 9(1). Nature Publishing Group
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Reactive oxygen species (ROS) function as second messengers in signal transduction, but high ROS levels can also cause cell death. MTH1 dephosphorylates oxidized nucleotides, thereby preventing their incorporation into DNA and protecting tumour cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfa3610160fd5848c5d0387b4a5965af
https://doi.org/10.1038/s41598-018-37316-w
https://doi.org/10.1038/s41598-018-37316-w
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0205536 (2018)
PLoS ONE
PLoS ONE
Background Aldehyde dehydrogenase 1A1 (ALDH1A1) encodes an enzyme that oxidizes aldehydes to their corresponding carboxylic acids. In colorectal cancer ALDH1A1 marks cancer stem cells and plays putative roles in tumor progression and drug resistance.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0eaac04bc9c7e4e41bc1a115bf53e37
http://europepmc.org/articles/PMC6181398?pdf=render
http://europepmc.org/articles/PMC6181398?pdf=render
Autor:
Lizet M, van der Waals, Jennifer M J, Jongen, Sjoerd G, Elias, Kateryna, Veremiyenko, Kari, Trumpi, Anne, Trinh, Jamila, Laoukili, Inge, Ubink, Susanne J, Schenning-van Schelven, Paul J, van Diest, Inne H M, Borel Rinkes, Onno, Kranenburg
Publikováno v:
The American journal of pathology. 188(10)
High levels of oxidative stress in disseminated colorectal cancer tumor cells may form a therapeutically exploitable vulnerability. However, it is unclear whether oxidative stress and damage persist in metastases. Therefore, we analyzed markers of ox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::167155b1dea509e73c2a97f85726fe57
https://pubmed.ncbi.nlm.nih.gov/30031728
https://pubmed.ncbi.nlm.nih.gov/30031728
Autor:
Klaas M. Govaert, Kari Trumpi, Onno Kranenburg, Jamila Laoukili, Lizet M. van der Waals, Inne H.M. Borel Rinkes, Niek A Peters, Jennifer M.J. Jongen, Susanne J Schenning-van Schelven
Publikováno v:
Oncotarget
Oncotarget, 8(49), 86296. Impact Journals
Oncotarget, 8(49), 86296. Impact Journals
Surgical removal of colorectal cancer (CRC) liver metastases generates areas of tissue hypoxia. Hypoxia imposes a stem-like phenotype on residual tumor cells and promotes tumor recurrence. Moreover, in primary CRC, gene expression signatures reflecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa37d63cb0f5b64ff72275a2871d874c
https://dspace.library.uu.nl/handle/1874/361512
https://dspace.library.uu.nl/handle/1874/361512
Autor:
Olivier G. de Jong, Marianne C. Verhaar, Bas W.M. van Balkom, Lizet M. van der Waals, Farah R. W. Kools
Publikováno v:
Journal of Cellular Physiology, 234(7), 10260. Wiley-Liss Inc.
Journal of Cellular Physiology
Journal of Cellular Physiology
Lysyl oxidase‐like 2 (LOXL2) belongs to the family of lysyl oxidases, and as such promotes crosslinking of collagens and elastin by oxidative deamination of lysine residues. In endothelial cells (ECs), LOXL2 is involved in crosslinking and scaffold
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6134a12faa11c699bc008d356d6ea71b
https://hdl.handle.net/1874/388659
https://hdl.handle.net/1874/388659
Autor:
Inne H.M. Borel Rinkes, Jennifer M.J. Jongen, Danielle A.E. Raats, Tobias B. Dansen, Lizet M. van der Waals, Onno Kranenburg
Publikováno v:
Clinical Cancer Research. 23:A29-A29
Background: Tumors are addicted to pathways neutralizing oxidative stress as a result of their high levels of reactive oxygen species (ROS). These ROS can oxidize nucleotides (NTs) within the precursor pool, which can cause cell death when incorporat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d90ce5c563256e938101f40ccc99021
https://doi.org/10.1158/1557-3265.pmccavuln16-a29
https://doi.org/10.1158/1557-3265.pmccavuln16-a29