Výsledky vyhledávání - "M. van der Kaaij"

Akademický článek

A Systematic Comparison Identifies an ATP-Based Viability Assay as Most Suitable Read-Out for Drug Screening in Glioma Stem-Like Cells

Autor: A. Kleijn, J. J. Kloezeman, R. K. Balvers, M. van der Kaaij, C. M. F. Dirven, S. Leenstra, M. L. M. Lamfers

Publikováno v: Stem Cells International, Vol 2016 (2016)

Serum-free culture methods for patient-derived primary glioma cultures, selecting for glioma stem-like cells (GSCs), are becoming the gold standard in neurooncology research. These GSCs can be implemented in drug screens to detect patient-specific re

Externí odkaz: https://doaj.org/article/f88954c35f294b5f8a79cfcd0cf2c588

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P414 Obesity is associated with a higher risk of immunogenicity to adalimumab, but not to infliximab in patients with Inflammatory Bowel Disease

Autor: J Louwers, B van Hellemondt, Remi Mahmoud, M van der Kaaij, J Schultheiss, Bas Oldenburg, P van Boeckel, Herma H. Fidder, Bindia Jharap, Nofel Mahmmod

Publikováno v: Journal of Crohn's and Colitis. 15:S420-S422

Background Globally, the prevalences of both inflammatory bowel diseases (IBD) and obesity have increased over the past decades. Recently, obesity has been linked to treatment failure in anti-TNF-treated patients with inflammatory bowel disease (IBD)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3c84908cffb8ed43ded775504e1f9d9d
https://doi.org/10.1093/ecco-jcc/jjab076.538

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P299 Loss-of-response to anti-tumour necrosis factor-α critically depends on treatment duration in patients with Inflammatory Bowel Disease

Autor: J Schultheiss, J Louwers, P van Boeckel, Herma H. Fidder, Bindia Jharap, Bas Oldenburg, Nofel Mahmmod, B van Hellemondt, M van der Kaaij, Remi Mahmoud

Publikováno v: Journal of Crohn's and Colitis. 15:S327-S328

Background Inflammatory bowel disease (IBD) is often managed with anti-tumour necrosis factor-α (anti-TNFα) compounds, but only few studies have reported on long-term outcomes. We aimed to determine whether the incidence of loss-of-response decreas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d86a1ae3f9b80fa5e3ee2a2f6402923a
https://doi.org/10.1093/ecco-jcc/jjab076.423

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Sublingual microcirculatory blood flow and vessel density in Sherpas at high altitude

Autor: Jildou M van der Kaaij, Martin Feelisch, Edward Gilbert-Kawai, Jonny Coppel, Denny Z. H. Levett, Jo Court, Michael P.W. Grocott, Daniel Martin, A. Vercueil, Monty G. Mythen

Publikováno v: Journal of Applied Physiology. 122:1011-1018

Anecdotal reports suggest that Sherpa highlanders demonstrate extraordinary tolerance to hypoxia at high altitude, despite exhibiting lower arterial oxygen content than acclimatized lowlanders. This study tested the hypothesis that Sherpas exposed to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a9ba3e57304326c9a9396b110b26a0b
https://doi.org/10.1152/japplphysiol.00970.2016

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The evolutionary origin and possible functional roles of FNIII domains in two Microbacterium aurum B8.A granular starch degrading enzymes, and in other carbohydrate acting enzymes

Autor: Vincent Valk, Rachel M. van der Kaaij, Lubbert Dijkhuizen

Publikováno v: Amylase. 1:1-11

Fibronectin type III (FNIII) domains were first identified in the eukaryotic plasma protein fibronectin, where they act as structural spacers or enable protein-protein interactions. Recently we characterized two large and multi-domain amylases in Mic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::239d37d6cf3525f8595147375c5d6f01
https://doi.org/10.1515/amylase-2017-0001

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DOP75 Loss-of-response and immunogenicity following immunomodulator withdrawal from anti-tumour necrosis factor alpha combination therapy: Results from a large retrospective cohort study

Autor: Bas Oldenburg, J Schultheiss, B van Hellemondt, M van der Kaaij, Remi Mahmoud, Bindia Jharap, J Louwers, Nofel Mahmmod, P van Boeckel, Herma H. Fidder

Publikováno v: Journal of Crohn's and Colitis. 15:S109-S109

Background Combination therapy with anti-TNF compounds and immunomodulators (IMM; thiopurine or methotrexate) is superior to IMM or anti-TNF monotherapy in patients with inflammatory bowel disease (IBD). IMMs are frequently discontinued during the ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d48f3d1afad995ef3f0cce878d0a5c02
https://doi.org/10.1093/ecco-jcc/jjab073.114

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Carbohydrate Binding Module 74 is a novel starch binding domain associated with large and multi-domain α-amylase enzymes

Autor: Vincent Valk, Rachel M. van der Kaaij, Lubbert Dijkhuizen, Alicia Lammerts van Bueren

Publikováno v: Febs Journal, 283(12):13745, 2354-2368. NLM (Medline)

Microbacterium aurum B8.A is a bacterium that originates from a potato starch-processing plant and employs a GH13 α-amylase (MaAmyA) enzyme that forms pores in potato starch granules. MaAmyA is a large and multi-modular protein that contains a novel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fea65fb1179ac62efc39b5f927ddea9a
https://hdl.handle.net/11370/a5c219db-2ede-4715-ae68-a2b637a40c5f

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A Systematic Comparison Identifies an ATP-Based Viability Assay as Most Suitable Read-Out for Drug Screening in Glioma Stem-Like Cells

Autor: Martine L.M. Lamfers, M. Van Der Kaaij, Anne Kleijn, Sieger Leenstra, Clemens M F Dirven, Jenneke Kloezeman, Rutger K. Balvers

Publikováno v: Stem Cells International
Stem Cells International, Vol 2016 (2016)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd37612a26d7f47e2df990fbcf48826e
https://doi.org/10.1155/2016/5623235

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P11.27 Drug screening of available anti-cancer drugs on patient-derived GBM cultures identifies candidate treatments for a subpopulation of GBM patients

Autor: Trisha Kers, M. Van Der Kaaij, Sieger Leenstra, J van Rij, Martine L.M. Lamfers, J.H.M. Prehn, Josie Hayes, Andreas Kremer, R Tching, Rutger K. Balvers, Clemens M F Dirven, Andreas U. Lindner, I Ntafoulis

Publikováno v: Neuro Oncol

BACKGROUND The development of new therapeutic agents generally takes many years to translate to clinically-effective new treatments. Among the strategies to reduce this time frame, efforts are now being undertaken to investigate drug repurposing. Wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e93a1e8074102e0e3d0e8a33ac66d2fe
https://doi.org/10.1093/neuonc/noz126.173

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P11.47 Generation, characterisation and drug screening of patient-derivedIDH1-mutated glioma cell lines

Autor: A.T. van der Ploeg, Youri Hoogstrate, Clemens M F Dirven, Martine L.M. Lamfers, Cassandra Verheul, M Aghababazadeh, E.A. Struys, M. C. Y. de Wit, Pim J. French, Trisha Kers, M. Van Der Kaaij, Sieger Leenstra

Publikováno v: Neuro Oncol

BACKGROUND Despite considerable scientific efforts, endogenous in vitro isocitrate dehydrogenase (IDH)-mutated glioma models remain scarce. Availability of these models is key to understanding underlying molecular mechanisms and vital for the develop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42d24f64535e1277364990dc25191e2c
https://doi.org/10.1093/neuonc/noz126.193

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