Zobrazeno 1 - 10
of 352
pro vyhledávání: '"M. van der Graaf"'
Autor:
Charlotte M. van der Graaf, Javier Sánchez-España, Andrey M. Ilin, Iñaki Yusta, Alfons J. M. Stams, Irene Sánchez-Andrea
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Hydrogen sulfide (H2S) in environments with temperatures below 100 °C is generally assumed to be of microbial origin, while abiotic H2S production is typically restricted to higher temperatures (T). In this study, we report an abiotic proce
Externí odkaz:
https://doaj.org/article/361a8c4332a241ce980f332c1805227f
Autor:
Linde F. Bouwman, Milou E.M. Joosen, Ronald A.M. Buijsen, Linda M. van der Graaf, Barry A. Pepers, Bas J.B. Voesenek, Erwin Brosens, Bart P.C. van de Warrenburg, Willeke M.C. van Roon-Mom
Publikováno v:
Stem Cell Research, Vol 78, Iss , Pp 103462- (2024)
Spinocerebellar Ataxia Type 7 (SCA7) is an autosomal dominantly inherited disorder, primarily characterized by cerebellar ataxia and visual loss. SCA7 is caused by a CAG repeat expansion in exon 3 of the ATXN7 gene. We generated human induced pluripo
Externí odkaz:
https://doaj.org/article/86fe66bc57d249828c2aae4cc8264041
Autor:
Ronald A. M. Buijsen, Linda M. van der Graaf, Elsa C. Kuijper, Barry A. Pepers, Elena Daoutsali, Lotte Weel, Vered Raz, David A. Parfitt, Willeke M. C. van Roon-Mom
Publikováno v:
Biomedicines, Vol 12, Iss 9, p 1933 (2024)
Antisense technology demonstrates significant potential for addressing inherited brain diseases, with over a dozen products already available and numerous others in the development pipeline. The versatility of differentiating induced pluripotent stem
Externí odkaz:
https://doaj.org/article/327ffa18f86647849ab4e8f6806628e2
Autor:
Elena Daoutsali, Barry A. Pepers, Stavros Stamatakis, Linda M. van der Graaf, Gisela M. Terwindt, David A. Parfitt, Ronald A. M. Buijsen, Willeke M. C. van Roon-Mom
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2023)
IntroductionADutch-type cerebral amyloid angiopathy (D-CAA) is a hereditary brain disorder caused by a point mutation in the amyloid precursor protein (APP) gene. The mutation is located within the amyloid beta (Aβ) domain of APP and leads to Aβ pe
Externí odkaz:
https://doaj.org/article/4a429a12a5844e2bbef696b3f8bd5abb
Autor:
A. M. Ilin, C. M. van der Graaf, I. Yusta, A. Sorrentino, I. Sánchez-Andrea, J. Sánchez-España
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Microbial sulfate (SO42−) reduction in Acid Mine Drainage (AMD) environments can ameliorate the acidity and extreme metal concentrations by consumption of protons via the reduction of SO42− to hydrogen sulfide (H2S) and the concomitant precipitat
Externí odkaz:
https://doaj.org/article/65c43cc920b84adfa4f86eedf39e8ffb
Autor:
Irene Sánchez-Andrea, Charlotte M. van der Graaf, Bastian Hornung, Nicole J. Bale, Monika Jarzembowska, Diana Z. Sousa, W. Irene C. Rijpstra, Jaap S. Sinninghe Damsté, Alfons J. M. Stams
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
In acid drainage environments, biosulfidogenesis by sulfate-reducing bacteria (SRB) attenuates the extreme conditions by enabling the precipitation of metals as their sulfides, and the neutralization of acidity through proton consumption. So far, onl
Externí odkaz:
https://doaj.org/article/43a86e870aae47a19f3db4eb2a08dd5c
Autor:
Ronald A.M. Buijsen, Sarah L. Gardiner, Marga J. Bouma, Linda M. van der Graaf, Merel W. Boogaard, Barry A. Pepers, Bert Eussen, Annelies de Klein, Christian Freund, Willeke M.C. van Roon-Mom
Publikováno v:
Stem Cell Research, Vol 29, Iss , Pp 125-128 (2018)
Spinocerebellar ataxia type 1 (SCA1) is a hereditary neurodegenerative disease caused by a CAG repeat expansion in exon 8 of the ATXN1 gene. We generated induced pluripotent stem cells (hiPSCs) from a SCA1 patient and his non-affected sister by using
Externí odkaz:
https://doaj.org/article/0f02888d0aa44a1ca13441a7103af8da
Autor:
Linda M. van der Graaf, Sarah L. Gardiner, Merve Tok, Tom Brands, Merel W. Boogaard, Barry A. Pepers, Bert Eussen, Annelies de Klein, N. Ahmad Aziz, Christian Freund, Ronald A.M. Buijsen, Willeke M.C. van Roon-Mom
Publikováno v:
Stem Cell Research, Vol 39, Iss , Pp - (2019)
Huntington disease (HD) is an autosomal dominant, neurodegenerative disease caused by a CAG repeat expansion within the coding sequence of the HTT gene, resulting in a highly toxic protein with an expanded polyglutamine stretch that forms typical pro
Externí odkaz:
https://doaj.org/article/3b35dbf51048451798c1c99a33881c96
Autor:
Elena Daoutsali, Ronald A.M. Buijsen, Simone van de Pas, Anke 't Jong, Harald Mikkers, Tom Brands, Bert Eussen, Annelies de Klein, Linda M. van der Graaf, Barry A. Pepers, Christian Freund, Gisela M. Terwindt, Valeria V. Orlova, Willeke M.C. van Roon-Mom
Publikováno v:
Stem Cell Research, Vol 34, Iss , Pp - (2019)
Hereditary Cerebral Hemorrhage with Amyloidosis-Dutch type (HCHWA-D) is an autosomal dominant hereditary disease caused by a point mutation in exon 17 of the APP gene. We generated human induced pluripotent stem cells (hiPSCs) from a symptomatic HCHW
Externí odkaz:
https://doaj.org/article/95930d38c64a4aaba11dcfaceede4516
Autor:
A Hindi-Assaf, M Van Der Graaf, N Van Boven, M J B Van Ettinger, M Hoogendijk, R Diletti, T Szili-Torok, D A M J Theuns, S C Yap
Publikováno v:
Europace. 25
Funding Acknowledgements Type of funding sources: None. Background The presence of an untreated chronic total coronary occlusion (CTO) is associated with a higher risk of ventricular arrhythmias (VAs). This increased risk may be modulated by the pres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7a5c38ac2f1f07741fb1c08df697fd1
https://doi.org/10.1093/europace/euad122.259
https://doi.org/10.1093/europace/euad122.259