Výsledky vyhledávání - "M. van Roest"

Akademický článek

Translation initiation factor eIF2Bε promotes Wnt-mediated clonogenicity and global translation in intestinal epithelial cells

Autor: W.L. Smit, R.J. de Boer, B.J. Meijer, C.N. Spaan, M. van Roest, P.J. Koelink, J. Koster, E. Dekker, T.E.M. Abbink, M.S. van der Knaap, G.R. van den Brink, V. Muncan, J. Heijmans

Publikováno v: Stem Cell Research, Vol 55, Iss , Pp 102499- (2021)

Modulation of global mRNA translation, which is essential for intestinal stem cell function, is controlled by Wnt signaling. Loss of tumor supressor APC in stem cells drives adenoma formation through hyperactivion of Wnt signaling and dysregulated tr

Externí odkaz: https://doaj.org/article/84a78e8e791e49e3a95ea30d0b47eb80

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P110 activation protein is strongly expressed in intestinal fibrosis in inflammatory bowel disease patients

Autor: D Lartey, M van Roest, J Verhoeff, J Grootjans, C Buskens, J van der Bilt, M Wildenberg, G D'Haens, M Löwenberg

Publikováno v: Journal of Crohn's and Colitis. 17:i273-i276

Background Intestinal fibrosis is a common complication of inflammatory bowel disease (IBD) with limited diagnostic modalities to detect and determine the degree of fibrosis. Fibroblast activation protein alpha (FAP) is a protein with both dipeptidyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::929e71f448f2dec87bb05b17c7a67b95
https://doi.org/10.1093/ecco-jcc/jjac190.0240

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Akademický článek

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Akademický článek

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P096 Characterization of suppressive immune cell subsets in mouse models of colitis-associated colorectal cancer

Autor: S Frigerio, J Saris, R Franco Fernandez, P Koelink, M van Roest, M Wildenberg, G D'Haens, J Grootjans

Publikováno v: Journal of Crohn's and Colitis. 17:i260-i260

Background Chronic colonic inflammation in inflammatory bowel disease (IBD) patients increases the risk of colitis-associated cancer (CAC). Cancer development in CAC is different from that observed in sporadic colorectal cancer (CRC). Most studies ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::64cf5014b01fbad91af6458a59dd4a60
https://doi.org/10.1093/ecco-jcc/jjac190.0226

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P084 Response to appendectomy in refractory Ulcerative Colitis appears based on two distinct inflammatory phenotypes

Autor: M Becker drs., L Heuthorst, M van Roest, J van der Bilt, C Buskens, M Wildenberg

Publikováno v: Journal of Crohn's and Colitis. 17:i248-i248

Background Appendectomy has been suggested to decrease the risk of disease flares in UC, but we recently showed that even in therapy refractory patients, appendectomy may improve symptoms in a subset of patients. Despite several hypotheses, the effec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6937cbd1f481c25abe09134ecb321b00
https://doi.org/10.1093/ecco-jcc/jjac190.0214

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Translation initiation factor eIF2Bε promotes Wnt-mediated clonogenicity and global translation in intestinal epithelial cells

Autor: G. R. van den Brink, Wouter L. Smit, M. S. Van Der Knaap, Jan Koster, Jarom Heijmans, M. van Roest, Pim J. Koelink, Evelien Dekker, Claudia N. Spaan, Bartolomeus J. Meijer, R.J. de Boer, Vanesa Muncan, Truus E.M. Abbink

Publikováno v: Stem cell research, 55:102499. Elsevier
Smit, W L, de Boer, R J, Meijer, B J, Spaan, C N, van Roest, M, Koelink, P J, Koster, J, Dekker, E, Abbink, T E M, van der Knaap, M S, van den Brink, G R, Muncan, V & Heijmans, J 2021, ' Translation initiation factor eIF2Bε promotes Wnt-mediated clonogenicity and global translation in intestinal epithelial cells ', Stem Cell Research, vol. 55, 102499 . https://doi.org/10.1016/j.scr.2021.102499
Stem Cell Research, Vol 55, Iss, Pp 102499-(2021)
Stem Cell Research, 55:102499. Elsevier

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d5df3b40aac6c8d011bc0f5ef896af5
https://pure.amc.nl/en/publications/translation-initiation-factor-eif2b-promotes-wntmediated-clonogenicity-and-global-translation-in-intestinal-epithelial-cells(493d7dc5-9adf-4b47-8bd5-ecbf0bd6455a).html

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Translation Initiation Factor eIF2Bε Promotes Stemness of Intestinal Epithelial Cells

Autor: Wouter L. Smit, Tem Abbink, R.J. de Boer, van der Knaap, Pim J. Koelink, Jan Koster, G. R. van den Brink, M. van Roest, Evelien Dekker, Bartolomeus J. Meijer, Vanesa Muncan, Jarom Heijmans, Claudia N. Spaan

Publikováno v: SSRN Electronic Journal.

Modulation of global mRNA translation is essential for intestinal stem cell function. In colorectal cancer, proliferating stem-like cells are defined by high WNT signaling and display dysregulated translational control. It is currently unclear how fa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2638b8fe53ad3fa677114356c493af44
https://doi.org/10.2139/ssrn.3666031

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Akademický článek

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Aryl hydrocarbon receptor activation affects the dendritic cell phenotype and function during allergic sensitization

Autor: Raymond Pieters, M.B.M. van Duursen, Joost J. Smit, M. Bol-Schoenmakers, M. van Roest, M. van den Berg, V.J. Schulz

Publikováno v: Immunobiology. 218:1055-1062

Aryl hydrocarbon receptor (AhR) activation by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) suppresses peanut sensitization by affecting T cell subsets. However, effects of AhR activation on dendritic cells (DC) in an allergic setting were not investiga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e24b2e0c9a98885e67bd27b0f692b545
https://doi.org/10.1016/j.imbio.2013.01.004

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