Dual thrombolytic therapy with mutant pro-urokinase and small bolus alteplase for ischemic stroke (DUMAS): study protocol for a multicenter randomized controlled phase II trial

Autor: Nadinda A. M. van der Ende, Bob Roozenbeek, Lucas E. M. Smagge, Sven P. R. Luijten, Leo A. M. Aerden, Petra Kraayeveld, Ido R. van den Wijngaard, Geert J. Lycklama à Nijeholt, Heleen M. den Hertog, H. Zwenneke Flach, Alexis C. Wallace, Victor Gurewich, Gregory J. del Zoppo, William J. Meurer, Hester F. Lingsma, Aad van der Lugt, Diederik W. J. Dippel, on behalf of the DUMAS Investigators

Publikováno v: Trials, Vol 23, Iss 1, Pp 1-10 (2022)

Abstract Background The effectiveness of alteplase for ischemic stroke treatment is limited, partly due to the occurrence of intracranial and extracranial hemorrhage. Mutant pro-urokinase (m-proUK) does not deplete fibrinogen and lyses fibrin only af

Externí odkaz: https://doaj.org/article/7dabe2305d8d4cf8b0cf8744c303141b

Continuous glucose monitoring in acute ischemic stroke patients treated with endovascular therapy: A pilot study to assess feasibility and accuracy.

Autor: C J B A Kersten, A A M Zandbergen, M J Fokkert, R J Slingerland, H M den Hertog

Publikováno v: PLoS ONE, Vol 18, Iss 2, p e0280153 (2023)

IntroductionHyperglycemia is common in acute ischemic stroke and is associated with larger infarct volume and unfavorable functional outcome, also in patients who undergo reperfusion therapy. Hyperglycemia during reperfusion may be a therapeutic targ

Externí odkaz: https://doaj.org/article/4a92ff25d77544d0af373365081d9474

Multicenter randomized clinical trial of endovascular treatment for acute ischemic stroke. The effect of periprocedural medication: acetylsalicylic acid, unfractionated heparin, both, or neither (MR CLEAN-MED). Rationale and study design

Autor: Vicky Chalos, Rob A. van de Graaf, Bob Roozenbeek, Adriaan C. G. M. van Es, Heleen M. den Hertog, Julie Staals, Lukas van Dijk, Sjoerd F.M. Jenniskens, Robert J. van Oostenbrugge, Wim H. van Zwam, Yvo B.W.E.M. Roos, Charles B.L.M. Majoie, Hester F. Lingsma, Aad van der Lugt, Diederik W.J. Dippel, on behalf of the MR CLEAN-MED investigators

Publikováno v: Trials, Vol 21, Iss 1, Pp 1-17 (2020)

Abstract Background Despite evidence of a quite large beneficial effect of endovascular treatment (EVT) for ischemic stroke caused by anterior circulation large vessel occlusion, many patients do not recover even after complete recanalization. To som

Externí odkaz: https://doaj.org/article/2e3db977f62d449d9be80d83cb5fdff3

Endovascular treatment versus no endovascular treatment after 6-24 h in patients with ischaemic stroke and collateral flow on CT angiography (MR CLEAN-LATE) in the Netherlands

Autor: Susanne G H Olthuis, F Anne V Pirson, Florentina M E Pinckaers, Wouter H Hinsenveld, Daan Nieboer, Angelique Ceulemans, Robrecht R M M Knapen, M M Quirien Robbe, Olvert A Berkhemer, Marianne A A van Walderveen, Geert J Lycklama à Nijeholt, Maarten Uyttenboogaart, Wouter J Schonewille, P Matthijs van der Sluijs, Lennard Wolff, Henk van Voorst, Alida A Postma, Stefan D Roosendaal, Anouk van der Hoorn, Bart J Emmer, Menno G M Krietemeijer, Pieter-Jan van Doormaal, Bob Roozenbeek, Robert-Jan B Goldhoorn, Julie Staals, Inger R de Ridder, Christiaan van der Leij, Jonathan M Coutinho, H Bart van der Worp, Rob T H Lo, Reinoud P H Bokkers, Ewoud I van Dijk, Hieronymus D Boogaarts, Marieke J H Wermer, Adriaan C G M van Es, Julia H van Tuijl, Hans G J Kortman, Rob A R Gons, Lonneke S F Yo, Jan-Albert Vos, Karlijn F de Laat, Lukas C van Dijk, Ido R van den Wijngaard, Jeannette Hofmeijer, Jasper M Martens, Paul J A M Brouwers, Tomas Bulut, Michel J M Remmers, Thijs E A M de Jong, Heleen M den Hertog, Boudewijn A A M van Hasselt, Anouk D Rozeman, Otto E H Elgersma, Bas van der Veen, Davy R Sudiono, Hester F Lingsma, Yvo B W E M Roos, Charles B L M Majoie, Aad van der Lugt, Diederik W J Dippel, Wim H van Zwam, Robert J van Oostenbrugge

Publikováno v: The Lancet (London), 401, 10385, pp. 1371-1380
The Lancet, 401(10385), 1371-1380. Elsevier Limited
The Lancet, 401(10385), 1371-1380. Elsevier Ltd.
The Lancet, 401(10385), 1371-1380. ELSEVIER SCIENCE INC
The Lancet (London), 401, 1371-1380
MR CLEAN-LATE investigators 2023, ' Endovascular treatment versus no endovascular treatment after 6–24 h in patients with ischaemic stroke and collateral flow on CT angiography (MR CLEAN-LATE) in the Netherlands : a multicentre, open-label, blinded-endpoint, randomised, controlled, phase 3 trial ', The Lancet, vol. 401, no. 10385, pp. 1371-1380 . https://doi.org/10.1016/S0140-6736(23)00575-5
Lancet, 401(10385), 1371-1380. Elsevier Science

BACKGROUND: Endovascular treatment for anterior circulation ischaemic stroke is effective and safe within a 6 h window. MR CLEAN-LATE aimed to assess efficacy and safety of endovascular treatment for patients treated in the late window (6-24 h from s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a46cfb9f76a2c972c8a03f6874d3840
https://doi.org/10.1016/s0140-6736(23)00575-5

Dexamethasone therapy versus surgery for chronic subdural haematoma (DECSA trial): study protocol for a randomised controlled trial

Autor: Ishita P. Miah, Dana C. Holl, Wilco C. Peul, Robert Walchenbach, Nyika Kruyt, Karlijn de Laat, Radboud W. Koot, Victor Volovici, Clemens M. F. Dirven, Fop van Kooten, Kuan H. Kho, Heleen M. den Hertog, Joukje van der Naalt, Bram Jacobs, Rob J. M. Groen, Hester F. Lingsma, Ruben Dammers, Korné Jellema, Niels A. van der Gaag, on behalf of the Dutch Subdural Hematoma Research Group (DSHR)

Publikováno v: Trials, Vol 19, Iss 1, Pp 1-10 (2018)

Abstract Background Chronic subdural haematoma (CSDH) is a common neurological disease with a rapidly rising incidence due to increasing age and widespread use of anticoagulants. Surgical intervention by burr-hole craniotomy (BHC) is the current stan

Externí odkaz: https://doaj.org/article/bc40ffa304714e38ab9f063cfb552677