Data from Preclinical Pharmacologic Evaluation of Pralatrexate and Romidepsin Confirms Potent Synergy of the Combination in a Murine Model of Human T-cell Lymphoma

Autor: Owen A. O'Connor, Susan E. Bates, Ronald Realubit, Charles Karan, Changchun Deng, Jennifer E. Amengual, Govind Bhagat, Yuan Zhang, Ying Wei, Tiffany Thomas, Serge Cremers, Kenneth P. Olive, Stephen A. Sastra, Carmine F. Palermo, Luigi Scotto, Kelly M. Zullo, Xavier Jirau-Serrano, Salvia Jain

Purpose: T-cell lymphomas (TCL) are aggressive diseases, which carry a poor prognosis. The emergence of new drugs for TCL has created a need to survey these agents in a rapid and reproducible fashion, to prioritize combinations which should be priori

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dd2dfddf7581dd54f3a7709c025e733
https://doi.org/10.1158/1078-0432.c.6524241.v1

Supplementary Figures 1-2, Supplementary Table 1 from Preclinical Pharmacologic Evaluation of Pralatrexate and Romidepsin Confirms Potent Synergy of the Combination in a Murine Model of Human T-cell Lymphoma

Autor: Owen A. O'Connor, Susan E. Bates, Ronald Realubit, Charles Karan, Changchun Deng, Jennifer E. Amengual, Govind Bhagat, Yuan Zhang, Ying Wei, Tiffany Thomas, Serge Cremers, Kenneth P. Olive, Stephen A. Sastra, Carmine F. Palermo, Luigi Scotto, Kelly M. Zullo, Xavier Jirau-Serrano, Salvia Jain

Supplementary Figures 1-2, Supplementary Table 1. Supplementary Figure 1: Highthroughput Matrix For H9 and HH. Highthroughput screen was used to determine the synergistic interaction in vitro in H9 and HH T-cell lines. (A) Depicts the observed percen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f762b80976191778cfffa83497553ca
https://doi.org/10.1158/1078-0432.22459545.v1

Video 1 from Aurora A Kinase Inhibition Selectively Synergizes with Histone Deacetylase Inhibitor through Cytokinesis Failure in T-cell Lymphoma

Autor: Owen A. O'Connor, Daruka Mahadevan, Jimmy Duong, Serge Cremers, Renu Nandakumar, Yinghui Mao, Jennifer E. Amengual, Luigi Scotto, Michael Mangone, Xavier Jirau-Serrano, Laurence Cooke, Yige Guo, Kelly M. Zullo

Video 1. Using a live cell imaging system, H9 cell line was treated from 0- 72 hours with (A) Untreated Control (B) 2 nM Romidepsin (C) 100 nM Alisertib (D) 2nM Romidepsin and 100 nM Alisertib. Videos demonstrate live cell imaging of H9 during the sp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17ceadd3e16ec423b7f885c274b0e0ba
https://doi.org/10.1158/1078-0432.22457019.v1

The adaptive aging brain

Autor: Joseph M. Zullo, Bruce A. Yankner, Liviu Aron

Publikováno v: Curr Opin Neurobiol

The aging brain is shaped by many structural and functional alterations. Recent cross-disciplinary efforts have uncovered powerful and integrated adaptive mechanisms that promote brain health and prevent functional decline during aging. Here, we revi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf6a943f56cf898fefce151ff3b81c17
https://doi.org/10.1016/j.conb.2021.09.009

DarkSide-20k: A 20 tonne two-phase LAr TPC for direct dark matter detection at LNGS

Autor: Craig E. Aalseth, P. F. Loverre, T. Viant, Fabrizio Giulio Luca Pilo, A. Vishneva, R. Perruzza, E. Segreto, P. Garcia Abia, T. N. Johnson, Manuel Colocci, Lelio Luzzi, R. Tartaglia, M. Bossa, S. Murphy, I. N. Machulin, M. Razeti, V. Pavletcov, M. Kuźniak, H. O. Back, N. Canci, P. D. Meyers, A.V. Shchagin, R. Cereseto, P. Skensved, Jocelyn Monroe, A. Buzulutskov, Davide Portaluppi, Giovanni Covone, G. Dellacasa, Vittorio Cataudella, P. Giampa, B. Rossi, D. Korablev, V. Pesudo, André Rubbia, Marco Pallavicini, Ivone F. M. Albuquerque, K. Fomenko, G. Fiorillo, G. Testera, K. Pelczar, A. Dolgov, F. Retiere, L. Shekhtman, George E. Froudakis, Mariano Cadoni, A. Moggi, L. Romero, M. La Commara, Aldo Ghisi, P. Cavalcante, S. Corgiolu, A. Oleinik, E. V. Hungerford, Cristiano Galbiati, Piero Salatino, D. D'Urso, M. Wada, Rosario Nania, M. Rescigno, Yuting Wang, T. Pollmann, Alan Watson, N. Rossi, C. J. Jillings, F. Gabriele, A. Empl, M. G. Boulay, S. Sanfilippo, A. Mandarano, S. J. M. Peeters, L. Pagani, M. D'Incecco, Alessandro Ferri, S. Westerdale, K. Keeter, R. Bunker, Claudio Piemonte, Andrea Alici, Federica Villa, D. Sablone, G. Di Pietro, Gilda Scioli, Allen Seifert, Marisa Gulino, P. Trinchese, G. Bonfini, S. Catalanotti, F. Granato, D. A. Semenov, M. Carlini, Luciano Pandola, A. Sotnikov, Min-Xin Guan, Alberto Tosi, H. Qian, M. D. Skorokhvatov, S. Bettarini, A. de Candia, An. Ianni, A. Sheshukov, W. Bonivento, V. Regazzoni, E. Pantic, F. Speziale, M. Mayer, Annalisa Vacca, X. Xiang, P. N. Singh, M. Gromov, S. Wu, A. G. Cocco, V. N. Muratova, B. Bottino, Andrea Gabrieli, Mario Giorgi, E. Sanchez Garcia, Jay W. Grate, Y. Suvorov, R. Milincic, G. Batignani, E. Bertoldo, M. Orsini, B. Radics, Giuseppe Longo, C. L. Kendziora, S. Bussino, M. Ave, V. Bocci, B. Reinhold, S. Dussoni, Eugenio Scapparone, A. L. Hallin, Richard M. Williams, S. Horikawa, B. Hosseini, S. Kim, D. Hughes, I. D'Antone, A. M. Goretti, A. S. Chepurnov, C. Giganti, I. J. Arnquist, Antonino Zichichi, A. Castellani, M. Fernandez Diaz, A. L. Renshaw, C. Filip, Silvia Arcelli, Fabio Acerbi, D. M. Asner, Monica Verducci, Marco Sant, Giovanni Paternoster, C. Dionisi, M. Da Rocha Rolo, S. Davini, C. J. Martoff, M. Marcante, M. Cadeddu, Paul H. Humble, E. Paoloni, Z. Ye, C. Cicalo, W. Mu, Laura A. Pellegrini, F. Pazzona, A. S. Kubankin, C. Savarese, G. Sobrero, Stefano Giagu, M. Caravati, A. A. Machado, Chung-Yao Yang, N. N. Nurakhov, G. Koh, Paolo Crivelli, M. Carpinelli, S. De Cecco, Fausto Ortica, G. De Rosa, I. Dormia, Federico Perotti, A. Yllera de Llano, Franco Zappa, J. Wahl, M. Guerzoni, Andrea Messina, Pietro Antonioli, Rudi Lussana, C. Cantini, Pierfranco Demontis, B. Vogelaar, O. Gorchakov, Angelo Rivetti, Simonetta Palmas, Hui Wang, Ben Loer, A. Devoto, J. Walding, Paolo Musico, Alberto Gola, G. Gibertoni, Thomas Alexander, I. Nikulin, D. A. Pugachev, R. Stainforth, A. Monte, A. V. Derbin, Andrey Sokolov, G. Zuzel, J. Maricic, A. B. McDonald, A. Zullo, L. Cifarelli, R. Santorelli, Giuseppe Baldovino Suffritti, Yanhui Ma, B. Schlitzer, Marino Simeone, Stefania Moioli, D. Franco, Michele Mascia, Mario Mariani, Raffaele Ardito, M. K. Daniel, C. Stanford, Mauro Citterio, A.E. Bondar, Caoxiang Zhu, O. Samoylov, Francesco Ragusa, R. K. Haaland, A. Gendotti, M. De Deo, G. Y. Grigoriev, A. Caminata, A. K. Alton, G. U. Lodi, G. Korga, Q. Riffard, M. Zullo, Xiujiang Li, Marco Grassi, M. Della Valle, C. Regenfus, Eric W. Hoppe, E. Vázquez-Jáuregui, L. Mapelli, Stefano Maria Mari, A. Tonazzo, A. Barrado Olmedo, V. Oleynikov, F. Di Eusanio, Maria Giuseppina Bisogni, B. J. Mount, Matteo Morrocchi, M. Kuss, E. Shemyakina, A. Candela, Aldo Romani, P. Agnes, G. K. Giovanetti, B. Lehnert, A. Razeto, Stefano Cavuoti, A. Navrer Agasson, V. Nosov, M. Cariello, N. Pelliccia, Simone Rizzardini, G. De Guido, M. Lissia, G. De Filippis, Marcin Wójcik, Anselmo Margotti, Xiang Xiao, Marcelo Braga Bueno Guerra, W. Sands, M. L. Gligan, A. O. Nozdrina, F. Raffaelli, G. Zappalà, A. Pocar, O. Smirnov, E. V. Unzhakov, B. Harrop

Publikováno v: The European Physical Journal Plus
The European Physical Journal Plus, Springer, 2018, 133 (3), ⟨10.1140/epjp/i2018-11973-4⟩
The European Physical Journal Plus, 2018, 133 (3), ⟨10.1140/epjp/i2018-11973-4⟩

Building on the successful experience in operating the DarkSide-50 detector, the DarkSide Collaboration is going to construct DarkSide-20k, a direct WIMP search detector using a two-phase Liquid Argon Time Projection Chamber (LAr TPC) with an active

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::245cbaddc23d7455ecec9e72b3bc9e68
http://hdl.handle.net/11391/1431247