Zobrazeno 1 - 10
of 59
pro vyhledávání: '"M. Zimanyi"'
Publikováno v:
Microscopy Today. 31:28-33
In the past decade, cryo-electron microscopy (cryoEM) has become a vital tool for structural biologists. Using cryoEM to determine structures of biomolecules at high resolution is a rapidly evolving technique with high barriers to entry for non-micro
Autor:
Aaron T Bozzi, Christina M Zimanyi, John M Nicoludis, Brandon K Lee, Casey H Zhang, Rachelle Gaudet
Publikováno v:
eLife, Vol 8 (2019)
Nramp family transporters—expressed in organisms from bacteria to humans—enable uptake of essential divalent transition metals via an alternating-access mechanism that also involves proton transport. We present high-resolution structures of Deino
Externí odkaz:
https://doaj.org/article/2ffaf0b83ca3479bb191db679e73d90c
Publikováno v:
Trends Biochem Sci
Cryogenic electron microscopy (cryoEM) uses images of frozen hydrated biological specimens to produce macromolecular structures, opening up previously inaccessible levels of biological organization to high-resolution structural analysis. CryoEM has t
Autor:
Niels Bradshaw, Vladimir M Levdikov, Christina M Zimanyi, Rachelle Gaudet, Anthony J Wilkinson, Richard Losick
Publikováno v:
eLife, Vol 6 (2017)
PP2C phosphatases control biological processes including stress responses, development, and cell division in all kingdoms of life. Diverse regulatory domains adapt PP2C phosphatases to specific functions, but how these domains control phosphatase act
Externí odkaz:
https://doaj.org/article/de37c6a6b1a045ee8256d4e20a33bf48
Autor:
Eugene Y.D. Chua, Joshua H. Mendez, Micah Rapp, Serban L. Ilca, Yong Zi Tan, Kashyap Maruthi, Huihui Kuang, Christina M. Zimanyi, Anchi Cheng, Edward T. Eng, Alex J. Noble, Clinton S. Potter, Bridget Carragher
Publikováno v:
Annual review of biochemistry. 91
Cryo–electron microscopy (cryo-EM) continues its remarkable growth as a method for visualizing biological objects, which has been driven by advances across the entire pipeline. Developments in both single-particle analysis and in situ tomography ha
Autor:
Christina M Zimanyi, Percival Yang-Ting Chen, Gyunghoon Kang, Michael A Funk, Catherine L Drennan
Publikováno v:
eLife, Vol 5 (2016)
Ribonucleotide reductase (RNR) converts ribonucleotides to deoxyribonucleotides, a reaction that is essential for DNA biosynthesis and repair. This enzyme is responsible for reducing all four ribonucleotide substrates, with specificity regulated by t
Externí odkaz:
https://doaj.org/article/3362bc8a86754788ba4ae10ed23599ad
Autor:
David Hirsh, Jonah Cheung, Goran Ahlsen, Christina M. Zimanyi, Tom Maniatis, Junqiang Ye, Valeria Gerbino
Publikováno v:
Proceedings of the National Academy of Sciences. 116:24517-24526
Exonic DNA sequence variants in the Tbk1 gene associate with both sporadic and familial amyotrophic lateral sclerosis (ALS). Here, we examine functional defects in 25 missense TBK1 mutations, focusing on kinase activity and protein-protein interactio
Autor:
Christina M Zimanyi, Gisele A. Andree, Allison E. Hamilos, Catherine L. Drennan, Michael A. Funk
Class Ia ribonucleotide reductases (RNRs) are subject to allosteric regulation to maintain the appropriate deoxyribonucleotide levels for accurate DNA biosynthesis and repair. RNR activity requires a precise alignment of its α2 and β2 subunits such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4cf3234532f925d3457d3b4450d0fcb
https://doi.org/10.1101/2021.07.31.454598
https://doi.org/10.1101/2021.07.31.454598
Publikováno v:
The Journal of General Physiology
An Nramp transition metal transporter performs metal uniport, proton uniport, and proton–metal cotransport. Transmembrane voltage and pH gradients govern the rates of these processes, largely through a conserved salt-bridge network in the transmemb
Autor:
Markus-Frederik Bohn, M. Zimanyi, Sayan Gupta, Corie Y. Ralston, Christopher J. Petzold, Natalia Sevillano, Charles S. Craik, Yan Chen
Publikováno v:
Biochimica et biophysica acta. Proteins and proteomics, vol 1869, iss 2
Biochim Biophys Acta Proteins Proteom
Biochim Biophys Acta Proteins Proteom
Affinity maturation of U33, a recombinant Fab inhibitor of uPA, was used to improve the affinity and the inhibitory effect compared to the parental Fab. Arginine scanning of the six CDR loops of U33 was done to identify initial binding determinants s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e113573369f950474c3d00e126073077
https://escholarship.org/uc/item/80d5x9cz
https://escholarship.org/uc/item/80d5x9cz