Zobrazeno 1 - 10
of 35
pro vyhledávání: '"M. Zangl"'
Autor:
Zachary S Morris, Won Jong Jin, Luke M Zangl, Meredith Hyun, Elian Massoud, Kaleb Schroeder, Roxana A Alexandridis
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 9 (2023)
Background Radiation therapy (RT) elicits DNA double-strand breaks, resulting in tumor cytotoxicity and a type I interferon (IFN) response via stimulator of interferon genes (STING) activation. We investigated whether combining RT with an ataxia-tela
Externí odkaz:
https://doaj.org/article/09fe93ac88ba4abb95865b23c2940f95
Autor:
Amber M. Bates, Ryan J. Brown, Alexander A. Pieper, Luke M. Zangl, Ian Arthur, Peter M. Carlson, Trang Le, Gustavo A. Sosa, Paul A. Clark, Raghava N. Sriramaneni, KyungMann Kim, Ravi B. Patel, Zachary S. Morris
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Surgical resection or hypo-fractionated radiation therapy (RT) in early-stage non-small cell lung cancer (NSCLC) achieves local tumor control, but metastatic relapse remains a challenge. We hypothesized that immunotherapy with anti-CTLA-4 and bempega
Externí odkaz:
https://doaj.org/article/a1b857248b16405ead2ae0e0249723e4
Autor:
L. Shao, S. Lengauer, H. Miri, M. Bedek, B. Kubicek, C. Kupfer, M. Zangl, B. Dienstbier, K. Jeitler, C. Krenn, T. Semlitsch, C. Zipp, D. Albert, A. Siebenhofer, T. Schreck
Publikováno v:
Proceedings of the 18th International Joint Conference on Computer Vision, Imaging and Computer Graphics Theory and Applications.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a093e0bfaca70e4b6d96c686985022c3
https://doi.org/10.5220/0011621800003417
https://doi.org/10.5220/0011621800003417
Autor:
Zachary S. Morris, Trang T. Le, Ian Marsh, Won Jong Jin, Peter M. Carlson, Raghava N. Sriramaneni, Jonathan W. Engle, Luke M. Zangl, Justin C. Jagodinsky, Amber M. Bates, Todd E. Barnhart, Joseph Grudzinski, Ian S. Arthur, Ravi Patel, Ryan J. Brown, Erin J. Nystuen, Reinier Hernandez, Ishan Chakravarty, Jamey P. Weichert, KyungMann Kim, Bryan Bednarz, Eduardo Aluicio-Sarduy, Caroline Kerr, Sarah E. Emma
Publikováno v:
Theranostics
Rationale: Clinical interest in combining targeted radionuclide therapies (TRT) with immunotherapies is growing. External beam radiation therapy (EBRT) activates a type 1 interferon (IFN1) response mediated via stimulator of interferon genes (STING),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daed47a443e514231d36d2cbac68e4e3
https://doi.org/10.7150/thno.54881
https://doi.org/10.7150/thno.54881
Autor:
Alexander A. Pieper, Luke M. Zangl, Dan V. Speigelman, Arika S. Feils, Anna Hoefges, Justin C. Jagodinsky, Mildred A. Felder, Noah W. Tsarovsky, Ian S. Arthur, Ryan J. Brown, Jen Birstler, Trang Le, Peter M. Carlson, Amber M. Bates, Jacquelyn A. Hank, Alexander L. Rakhmilevich, Amy K. Erbe, Paul M. Sondel, Ravi B. Patel, Zachary S. Morris
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
IntroductionCombining CpG oligodeoxynucleotides with anti-OX40 agonist antibody (CpG+OX40) is able to generate an effective in situ vaccine in some tumor models, including the A20 lymphoma model. Immunologically “cold” tumors, which are typically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::327ec42dd203299261d8daddeafabe80
https://doi.org/10.3389/fimmu.2021.763888
https://doi.org/10.3389/fimmu.2021.763888
Autor:
Ravi Patel, Sritha Moram, Zachary S. Morris, Mildred Felder, Anna Hoefges, Jacquelyn A. Hank, Luke M. Zangl, Arika Feils, Dan Spiegelman, Amy K. Erbe, Alexander L. Rakhmilevich, Alexander A. Pieper, Paul M. Sondel
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundWe, and others, have previously shown that the in-situ vaccine of hypomethylated CG-enriched oligodeoxynucleotide (CpG) with agonist anti-OX40 antibody (OX40) is effective at curing mice in the A20 lymphoma model [1–4]. In separate precli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::252ca648bc25d850bf91db85a1cc68d5
https://doaj.org/article/ba7ea0b6a9b349449d5ef3b343985367
https://doaj.org/article/ba7ea0b6a9b349449d5ef3b343985367
Autor:
Jacquelyn A. Hank, Zachary S. Morris, Arika Feils, Luke M. Zangl, Mackenzie Heck, Paul M. Sondel, Anna Hoefges, Peter M. Carlson, Amy K. Erbe, Ravi Patel, Dmitriy Kravtsov, Alexander L. Rakhmilevich
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background Mice bearing B78 melanoma tumors can be cured using an in situ vaccine (ISV) regimen that includes radiation (RT) together with immunocytokine (tumor-targeting mAb conjugated to IL-2). B78 melanoma cells, derived from B16 cells, express mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a0e99ae157ad4d96c41cd15cbe802ab
https://doi.org/10.1136/jitc-2020-sitc2020.0823
https://doi.org/10.1136/jitc-2020-sitc2020.0823
Autor:
Ryan J. Brown, Ian S. Arthur, Erin J. Nystuen, Ravi Patel, Luke M. Zangl, Ishan Chakravarty, Zachary S. Morris, Ian Marsh, Joseph Grudzinski, KyungMann Kim, Justin C. Jagodinsky, Amber M. Bates, Jamey P. Weichert, Bryan Bednarz, Todd E. Barnhart, Eduardo Aluicio-Sarduy, Trang T. Le, Won Jong Jin, Peter M. Carlson, Sarah E. Emma, Caroline Kerr, Jonathan W. Engle, Reinier Hernandez
Publikováno v:
Cancer Research. 81:3060-3060
Background: Radiation (RT) activates a type 1 interferon (IFN1) response and this is critical to the effect of RT in priming a response to immune checkpoint blockade (ie anti-CTLA4). However, little is known about the time course of this effect. Clin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba3efdd4df97c84064850ebeb05a15f2
https://doi.org/10.1158/1538-7445.am2021-3060
https://doi.org/10.1158/1538-7445.am2021-3060
Autor:
Zachary S. Morris, Luke M. Zangl, Ian Marsh, Peter M. Carlson, Juliana S. Castillo, Reinier Hernandez, Jamey P. Weichert, Bryan Bednarz, Wonjon J. Jin, Joseph Grudzinski, Ishan Chakravarty, Justin C. Jagodinsky, Ryan J. Brown, Ian S. Arthur, Ravi Patel
Publikováno v:
Cancer Research. 80:477-477
Background: Radiation (RT) activates a type 1 interferon (IFN-1) response and, in preclinical studies, this is critical to the effect of RT in priming a response to immune checkpoint blockade. Recent studies report the impact of external beam radioth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea78dce7e4ac838938f02aa02cd965ce
https://doi.org/10.1158/1538-7445.am2020-477
https://doi.org/10.1158/1538-7445.am2020-477
Autor:
Juliana S. Castillo, Alex Pieper, Peter M. Carlson, Luke M. Zangl, Paul M. Sondel, Zach S. Morris, Ryan J. Brown, Alexander L. Rakhmilevich, Ian S. Arthur, Ravi Patel
Publikováno v:
Cancer Research. 80:4455-4455
Purpose: Surgical resection or stereotactic ablative radiation therapy (SBRT) in early stage non-small cell lung cancer (NSCLC) have local control rates of 90% or higher. Current treatment paradigms effectively control primary tumor sites, but distan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b00b2f535cda1d57a6142148e47d9740
https://doi.org/10.1158/1538-7445.am2020-4455
https://doi.org/10.1158/1538-7445.am2020-4455