Zobrazeno 1 - 10
of 86
pro vyhledávání: '"M. Zameel Cader"'
Autor:
Despoina Charou, Thanasis Rogdakis, Alessia Latorrata, Maria Valcarcel, Vasileios Papadogiannis, Christina Athanasiou, Alexandros Tsengenes, Maria Anna Papadopoulou, Dimitrios Lypitkas, Matthieu D. Lavigne, Theodora Katsila, Rebecca C. Wade, M. Zameel Cader, Theodora Calogeropoulou, Achille Gravanis, Ioannis Charalampopoulos
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Background Neural stem cell (NSC) proliferation and differentiation in the mammalian brain decreases to minimal levels postnatally. Nevertheless, neurogenic niches persist in the adult cortex and hippocampus in rodents, primates and humans,
Externí odkaz:
https://doaj.org/article/780a53ab9410470abce7ed5369ab372b
Autor:
Stergios Tsartsalis, Hannah Sleven, Nurun Fancy, Frank Wessely, Amy M. Smith, Nanet Willumsen, To Ka Dorcas Cheung, Michal J. Rokicki, Vicky Chau, Eseoghene Ifie, Combiz Khozoie, Olaf Ansorge, Xin Yang, Marion H. Jenkyns, Karen Davey, Aisling McGarry, Robert C. J. Muirhead, Stephanie Debette, Johanna S. Jackson, Axel Montagne, David R. Owen, J. Scott Miners, Seth Love, Caleb Webber, M. Zameel Cader, Paul M. Matthews
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Brain perfusion and blood-brain barrier (BBB) integrity are reduced early in Alzheimer’s disease (AD). We performed single nucleus RNA sequencing of vascular cells isolated from AD and non-diseased control brains to characterise pathologic
Externí odkaz:
https://doaj.org/article/6d33fcf5b51e487193ad2c53717ad721
Publikováno v:
Cells, Vol 13, Iss 15, p 1260 (2024)
A substantial challenge in human brain aging is to find a suitable model to mimic neuronal aging in vitro as accurately as possible. Using directly converted neurons (iNs) from human fibroblasts is considered a promising tool in human aging since it
Externí odkaz:
https://doaj.org/article/a421742851144230932fedb1e6987278
Autor:
Jimena Monzón-Sandoval, Elena Burlacu, Devika Agarwal, Adam E. Handel, Liting Wei, John Davis, Sally A. Cowley, M. Zameel Cader, Caleb Webber
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 10 (2022)
Externí odkaz:
https://doaj.org/article/71d2d166952149deaacfd3fb1e483bae
Autor:
Neven Maksemous, Claire D. Blayney, Heidi G. Sutherland, Robert A. Smith, Rod A. Lea, Kim Ngan Tran, Omar Ibrahim, Jeffrey R. McArthur, Larisa M. Haupt, M. Zameel Cader, Rocio K. Finol-Urdaneta, David J. Adams, Lyn R. Griffiths
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Familial hemiplegic migraine (FHM) is a severe neurogenetic disorder for which three causal genes, CACNA1A, SCN1A, and ATP1A2, have been implicated. However, more than 80% of referred diagnostic cases of hemiplegic migraine (HM) are negative for exon
Externí odkaz:
https://doaj.org/article/483ec272a040492885598e5a29002b7f
Autor:
Tatjana Lalic, Aiste Steponenaite, Liting Wei, Sridhar R. Vasudevan, Alistair Mathie, Stuart N. Peirson, Gurprit S. Lall, M. Zameel Cader
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
The suprachiasmatic nucleus (SCN) ensures rhythmic electrical activity that varies between day and night to determine circadian behaviours. The authors show that TRESK channels provide a feedback mechanism to maintain the SCN in the appropriate state
Externí odkaz:
https://doaj.org/article/92d80056b5bc4ccbb603e1addb6b05b5
Autor:
Maximilian Zeidler, Kai K. Kummer, Clemens L. Schöpf, Theodora Kalpachidou, Georg Kern, M. Zameel Cader, Michaela Kress
Publikováno v:
Advanced Science, Vol 8, Iss 21, Pp n/a-n/a (2021)
Abstract Nociceptors are primary afferent neurons serving the reception of acute pain but also the transit into maladaptive pain disorders. Since native human nociceptors are hardly available for mechanistic functional research, and rodent models do
Externí odkaz:
https://doaj.org/article/6fedb1b7aeee45249f1ddcbc2a78ea31
Autor:
Viola Volpato, James Smith, Cynthia Sandor, Janina S. Ried, Anna Baud, Adam Handel, Sarah E. Newey, Frank Wessely, Moustafa Attar, Emma Whiteley, Satyan Chintawar, An Verheyen, Thomas Barta, Majlinda Lako, Lyle Armstrong, Caroline Muschet, Anna Artati, Carlo Cusulin, Klaus Christensen, Christoph Patsch, Eshita Sharma, Jerome Nicod, Philip Brownjohn, Victoria Stubbs, Wendy E. Heywood, Paul Gissen, Roberta De Filippis, Katharina Janssen, Peter Reinhardt, Jerzy Adamski, Ines Royaux, Pieter J. Peeters, Georg C. Terstappen, Martin Graf, Frederick J. Livesey, Colin J. Akerman, Kevin Mills, Rory Bowden, George Nicholson, Caleb Webber, M. Zameel Cader, Viktor Lakics
Publikováno v:
Stem Cell Reports, Vol 11, Iss 4, Pp 897-911 (2018)
Summary: Reproducibility in molecular and cellular studies is fundamental to scientific discovery. To establish the reproducibility of a well-defined long-term neuronal differentiation protocol, we repeated the cellular and molecular comparison of th
Externí odkaz:
https://doaj.org/article/de4461b1cd604cd1b890c370ecec071c
Autor:
Chenglong Xie, Yahyah Aman, Bryan A. Adriaanse, M. Zameel Cader, Hélène Plun-Favreau, Jian Xiao, Evandro F. Fang
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2020)
Mitophagy is a selective engulfment and degradation of damaged mitochondria through the cellular autophagy machinery, a major mechanism responsible for mitochondrial quality control. Increased accumulation of damaged mitochondria in the Alzheimer’s
Externí odkaz:
https://doaj.org/article/6027f392ed00445891936a0b2875bada
Autor:
Walther Haenseler, Stephen N. Sansom, Julian Buchrieser, Sarah E. Newey, Craig S. Moore, Francesca J. Nicholls, Satyan Chintawar, Christian Schnell, Jack P. Antel, Nicholas D. Allen, M. Zameel Cader, Richard Wade-Martins, William S. James, Sally A. Cowley
Publikováno v:
Stem Cell Reports, Vol 8, Iss 6, Pp 1727-1742 (2017)
Microglia are increasingly implicated in brain pathology, particularly neurodegenerative disease, with many genes implicated in Alzheimer's, Parkinson's, and motor neuron disease expressed in microglia. There is, therefore, a need for authentic, effi
Externí odkaz:
https://doaj.org/article/edac014090934a7e8219864d7c951707