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Akademický článek

A ligand discovery toolbox for the WWE domain family of human E3 ligases

Autor: Lena Münzker, Serah W. Kimani, Milan M. Fowkes, Aiping Dong, Hong Zheng, Yanjun Li, Morgan Dasovich, Krzysztof M. Zak, Anthony K. L. Leung, Jonathan M. Elkins, Dirk Kessler, Cheryl H. Arrowsmith, Levon Halabelian, Jark Böttcher

Publikováno v: Communications Biology, Vol 7, Iss 1, Pp 1-15 (2024)

Abstract The WWE domain is a relatively under-researched domain found in twelve human proteins and characterized by a conserved tryptophan-tryptophan-glutamate (WWE) sequence motif. Six of these WWE domain-containing proteins also contain domains wit

Externí odkaz: https://doaj.org/article/d563b7d731e84d30bedff15301871bf2

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Akademický článek

Modulation of peroxisomal import by the PEX13 SH3 domain and a proximal FxxxF binding motif

Autor: Stefan Gaussmann, Rebecca Peschel, Julia Ott, Krzysztof M. Zak, Judit Sastre, Florent Delhommel, Grzegorz M. Popowicz, Job Boekhoven, Wolfgang Schliebs, Ralf Erdmann, Michael Sattler

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)

Abstract Import of proteins into peroxisomes depends on PEX5, PEX13 and PEX14. By combining biochemical methods and structural biology, we show that the C-terminal SH3 domain of PEX13 mediates intramolecular interactions with a proximal FxxxF motif.

Externí odkaz: https://doaj.org/article/89d258036d6146bbb1acbb853157ad7f

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Fault Detection for Multi-terminal Transmission Line with Nuclear Power Plant Based on Wavelet Transform Ahmed R. Adly(1),*, Alaa M. Abdel-hamed (2), Said A. Kotb (1), Magdy M. Zak (1) 1) ETRR-2, Nuclear Research Center, Atomic Energy Authority, Egypt 2) High Institute of Engineering, EL Shorouk Academy, Egypt

Autor: Magdy M. Zaky, Said A. Kotb, Ahmed R. Adly

Publikováno v: Arab Journal of Nuclear Sciences and Applications. 52:144-152

This paper proposes an improved scheme of fault detection and classification for multi-terminal transmission lines using discrete wavelet transform (DWT). The proposed scheme can correctly used to detect and classify the faults. The proposed scheme i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::620045b718114816198ff1d7a3446559
https://doi.org/10.21608/ajnsa.2019.6832.1162

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Akademický článek

Don't skip a beat! Critical findings in imaging studies performed in adults with congenital heart disease

Autor: Robb, Caroline, Rajput, M. Zak, Raptis, Demetrios, Bhalla, Sanjeev

Publikováno v: In Current Problems in Diagnostic Radiology March-April 2024 53(2):297-307

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Akademický článek

Cryo-EM structure of human eIF5A-DHS complex reveals the molecular basis of hypusination-associated neurodegenerative disorders

Autor: Elżbieta Wątor, Piotr Wilk, Artur Biela, Michał Rawski, Krzysztof M. Zak, Wieland Steinchen, Gert Bange, Sebastian Glatt, Przemysław Grudnik

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)

eIF5A is the only protein known to contain hypusine. Here, the authors present the cryoEM structure of the eIF5A-DHS complex and provide mechanistic insights to understand the deoxyhypusination reaction and hypusination-related neurodegeneration.

Externí odkaz: https://doaj.org/article/e4e3adc8dd2e42ca879034e54b682cda

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Akademický článek

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Akademický článek

Latency, thermal stability, and identification of an inhibitory compound of mirolysin, a secretory protease of the human periodontopathogen Tannerella forsythia

Autor: Krzysztof M. Zak, Mark J. Bostock, Irena Waligorska, Ida B. Thøgersen, Jan J. Enghild, Grzegorz M. Popowicz, Przemyslaw Grudnik, Jan Potempa, Miroslaw Ksiazek

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1267-1281 (2021)

Mirolysin is a secretory protease of Tannerella forsythia, a member of the dysbiotic oral microbiota responsible for periodontitis. In this study, we show that mirolysin latency is achieved by a “cysteine-switch” mechanism exerted by Cys23 in the

Externí odkaz: https://doaj.org/article/facc41ee0c7f40019822708c69e05cfb

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