Zobrazeno 1 - 10
of 61
pro vyhledávání: '"M. Yvonne Alexander"'
Autor:
Gary P. Sidgwick, Ria Weston, Ayman M. Mahmoud, Andrew Schiro, Ferdinand Serracino-Inglott, Shikha M. Tandel, Sarah Skeoch, Ian N. Bruce, Alan M. Jones, M. Yvonne Alexander, Fiona L. Wilkinson
Publikováno v:
Cells, Vol 13, Iss 4, p 312 (2024)
Heparan sulphate (HS) can act as a co-receptor on the cell surface and alterations in this process underpin many pathological conditions. We have previously described the usefulness of mimics of HS (glycomimetics) in protection against β-glycerophos
Externí odkaz:
https://doaj.org/article/23fe648e87074950baf042e9c80d7f74
Autor:
Ayman M. Mahmoud, Alan M. Jones, Gary P. Sidgwick, Ayman M. Arafat, M. Yvonne Alexander, Fiona L. Wilkinson
Publikováno v:
Cellular Physiology and Biochemistry, Vol 53, Iss 2, Pp 323-336 (2019)
Externí odkaz:
https://doaj.org/article/22fe1fe87d2a4ee19753c525c9872919
Publikováno v:
Frontiers in Medicine, Vol 5 (2018)
Over the past decade, we have witnessed an exponential growth of interest into the role of endothelial progenitor cells (EPCs) in cardiovascular disease. While the major thinking revolves around EPC angiogenic repair properties, we have used a hypoth
Externí odkaz:
https://doaj.org/article/5614edad1b7f4f3080ddd1e1776e376b
Autor:
Marinônio Lopes Cornélio, Ana Paula R. Povinelli, Alan M. Jones, M. Yvonne Alexander, Fiona L. Wilkinson, Gabriel Zazeri, Ayman M. Mahmoud, Daniel M. Gill, Sabrina A. Shamir
Publikováno v:
Web of Science
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
RSC Medicinal Chemistry
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
RSC Medicinal Chemistry
The conceptual technology of small molecule glycomimetics, exemplified by compounds C1–4, has shown promising protective effects against lipid-induced endothelial dysfunction, restorative effects on diabetic endothelial colony forming cells, and pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ea596b45cafb9046783b12e8abdeb8e
Autor:
M. Yvonne Alexander, Francesca Bartoli-Leonard, Ferdinand Serracino Inglott, Ria Weston, Fiona L. Wilkinson, Andrew Schiro
Publikováno v:
Cardiovascular Research
Aims Vascular calcification is a recognised predictor of cardiovascular risk in the diabetic patient, with DNA damage and accelerated senescence linked to oxidative stress associated pathological calcification. Having previously shown that systemic S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea4868b22d5790c78e2e9ea8b80dee1c
https://e-space.mmu.ac.uk/626077/
https://e-space.mmu.ac.uk/626077/
Autor:
Phillip Pemberton, Zia Moinuddin, Hussein Khambalia, Angela Summers, David van Dellen, M. Yvonne Alexander, Mahesan Nirmalan, Titus Augustine, Ria Weston
Publikováno v:
Cytokine. 105:8-16
© 2018 Elsevier Ltd. In sepsis, trauma and major surgery, where an explicit physiological insult leads to a significant systemic inflammatory response, the acute evolution of biomarkers have been delineated. In these settings, Interleukin (IL) -6 an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f737a0dafc203c300e4ed6abc029b455
https://doi.org/10.1016/j.cyto.2018.01.006
https://doi.org/10.1016/j.cyto.2018.01.006
Autor:
M. Yvonne Alexander, Alex Langford-Smith, Miguel Romero, Eoghan M. McCarthy, Ayman M. Mahmoud, Juan Duarte, Fiona L. Wilkinson, Daniel M. Moreno-Martinez
Publikováno v:
The FASEB Journal
Endothelial microparticles (EMPs) are endothelium-derived submicron vesicles that are released in response to diverse stimuli and are elevated in cardiovascular disease, which is correlated with risk factors. This study investigates the effect of EMP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::773936cc08d190a26637cd737ab0099c
https://doi.org/10.1096/fj.201601244rr
https://doi.org/10.1096/fj.201601244rr
Autor:
Fiona L. Wilkinson, Nicos Mitsides, Paul Brenchley, Liliana Shalamanova, M. Yvonne Alexander, Geoffrey J. M. Parker, Damien Mc Hough, Agnieszka Swiecicka, Roshni Mitra, Jane Alderdice, Sandip Mitra, Fahad Mohammaed S Alsehli
Publikováno v:
Mitsides, N, Alsehli, F M S, Mc Hough, D, Shalamanova, L, Wilkinson, F, Alderdice, J, Mitra, R, Swiecicka, A, Brenchley, P, Parker, G J M, Alexander, M Y & Mitra, S 2019, ' Salt and Water Retention Is Associated with Microinflammation and Endothelial Injury in Chronic Kidney Disease ', The Nephron Journals, pp. 1-9 . https://doi.org/10.1159/000502011
Background: Progressive chronic kidney disease (CKD) inevitably leads to salt and water retention and disturbances in the macro-and microcirculation. Objectives: We hypothesize that salt and water dysregulation in advanced CKD may be linked to inflam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18848e2d5742fed2bfb35426b35820f7
https://e-space.mmu.ac.uk/624046/
https://e-space.mmu.ac.uk/624046/
Publikováno v:
Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity, Vol 2019 (2019)
Oxidative Medicine and Cellular Longevity, Vol 2019 (2019)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::751f8d3611f1ebfd83b286c06bca3040
http://europepmc.org/articles/PMC6620855
http://europepmc.org/articles/PMC6620855
Autor:
Alex Langford-Smith, Ahmad Hasan, Frank L. Bowling, M. Yvonne Alexander, Andrew J.M. Boulton, S. Tawqeer Rashid, Ria Weston, Alan M. Jones, Nicola C. Edwards, Fiona L. Wilkinson
Publikováno v:
Scientific Reports
Langford-Smith, A W W, Hasan, A, Weston, R, Edwards, N, Jones, A M, Boulton, A J M, Bowling, F L, Rashid, S T, Wilkinson, F L & Alexander, M Y 2019, ' Diabetic endothelial colony forming cells have the potential for restoration with glycomimetics ', Scientific Reports, vol. 9, no. 1, 2309 . https://doi.org/10.1038/s41598-019-38921-z
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Langford-Smith, A W W, Hasan, A, Weston, R, Edwards, N, Jones, A M, Boulton, A J M, Bowling, F L, Rashid, S T, Wilkinson, F L & Alexander, M Y 2019, ' Diabetic endothelial colony forming cells have the potential for restoration with glycomimetics ', Scientific Reports, vol. 9, no. 1, 2309 . https://doi.org/10.1038/s41598-019-38921-z
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Endothelial colony forming progenitor cell (ECFC) function is compromised in diabetes, leading to poor vascular endothelial repair, which contributes to impaired diabetic foot ulcer healing. We have generated novel glycomimetic drugs with protective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07a92975453c000c7214b841323a2ab4
https://doi.org/10.1038/s41598-019-38921-z
https://doi.org/10.1038/s41598-019-38921-z