Zobrazeno 1 - 10
of 13
pro vyhledávání: '"M. Yu. Vyssokikh"'
Publikováno v:
Медицинская иммунология, Vol 26, Iss 4, Pp 685-692 (2024)
The naked mole-rat (NMR) is a unique long-lived rodent with low cancer incidence. Understanding the molecular mechanisms that NMR evolved to control aging and tumorigenesis is important for biomedicine. It is commonly accepted that the immune system
Externí odkaz:
https://doaj.org/article/45b254f7f54d4c90ba56f6f89fb5bd89
Autor:
V. P. Skulachev, M. Yu. Vyssokikh, B. V. Chernyak, O. A. Averina, A. A. Andreev-Andrievskiy, R. A. Zinovkin, K. G. Lyamzaev, M. V. Marey, M. V. Egorov, O. J. Frolova, D. B. Zorov, M. V. Skulachev, V. A. Sadovnichii
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract The response to stress involves the activation of pathways leading either to protection from the stress origin, eventually resulting in development of stress resistance, or activation of the rapid death of the organism. Here we hypothesize t
Externí odkaz:
https://doaj.org/article/f1f5e0d891b848d3bbeaa4868a3d756e
Autor:
M. V. Zhuravleva, M. V. Granovskaya, K. Ya. Zaslavskaya, Yu. G. Kazaishvili, V. S. Scherbakova, A. A. Andreev-Andrievskiy, D. I. Pozdnyakov, M. Yu. Vyssokikh
Publikováno v:
Фармация и фармакология (Пятигорск), Vol 10, Iss 4, Pp 387-399 (2022)
The article presents the results of an in vitro study of the synergetic effect evaluation of the combined preparation based on coordination complex ethylmethylhydroxypyridine succinate and trimethylhydrazinium propionate on energy metabolism and cell
Externí odkaz:
https://doaj.org/article/18f957b6eafd41c9ba5fa2204b913166
Effect of a mitochondria-targeted antioxidant on ageing of Podospora anserina: Ultrastructural study
Publikováno v:
Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology. 4:38-42
A beneficial effect of mitochondria targeted antioxidant (MTA) SkQ1 added to the culture medium on life span of Podospora anserina was revealed. As was shown earlier, optimal concentration was 400 nM. SkQ1 was shown to increase P. anserina life span
Publikováno v:
Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology. 2:33-39
Autor:
M. Yu. Vyssokikh, V. V. Emelyanov
Publikováno v:
Biochemistry (Moscow). 71:730-735
Mitochondrial porin was identified in Rickettsia prowazekii by Western blot analysis of whole cells and membrane fractions with monoclonal antibody against porin VDAC 1 of animal mitochondria. Using the BLAST server, no protein sequences homologous t
Publikováno v:
Bioscience Reports. 23:67-75
Acidification of a high phosphate incubation medium from pH 7.4 to 6.5 promotes increase in rates of succinate oxidation and exogenous NADH oxidation via external (rotenone-and myxothiazol-resistant) pathway by factors 2 and 2.3 respectively. Cyclosp
Publikováno v:
CrossRef Listing of Deleted DOIs.
Effects of the coenzyme Q analog (MitoQ10) carrying a positively charged decyltetraphenylphosphonium group on functional activity of phosphorylating liver mitochondria were studied. Using inhibitory analysis it was found that at micromolar concentrat
Autor:
V. M. Mikhelson, T. A. Samoylova, Vladimir N. Anisimov, Irina G. Popovich, M. Yu. Vyssokikh, Maria N. Yurova, Alisa A. Panteleeva, Anna V. Semenchenko, M. A. Zabezhinsky, Vladimir P. Skulachev, N. V. Roshchina, E. A. Tsybul’ko, Maxim V. Skulachev, O. Yu. Rybina, Lora E. Bakeeva, D. I. Pilipenko, E. F. Isakova, Egormin Pa, T. S. Piskunova, Tyndyk Ml, V. B. Saprunova, Elena G. Pasyukova, O. F. Filenko, Vasily N. Manskikh, Irina Spivak
Publikováno v:
Biochemistry. Biokhimiia. 73(12)
Very low (nano- and subnanomolar) concentrations of 10-(6′-plastoquinonyl) decyltriphenylphosphonium (SkQ1) were found to prolong lifespan of a fungus (Podospora anserina), a crustacean (Ceriodaphnia affinis), an insect (Drosophila melanogaster), a
Autor:
O. Yu. Pletjushkina, Lora E. Bakeeva, Tatyana I. Rokitskaya, Antonina V. Pustovidko, Maxim V. Skulachev, Vadim N. Tashlitsky, Boris V. Chernyak, D. S. Izyumov, A. V. Avetisyan, A. A. Pashkovskaya, Yuri N. Antonenko, Maria S. Muntyan, I. V. Skulachev, Lev S. Yaguzhinsky, Vyacheslav A. Chertkov, Galina A. Korshunova, Vladimir P. Skulachev, Vitaly A. Roginsky, Inna I. Severina, Khailova Ls, O. K. Nepryakhina, J. M. Vassiliev, I. V. Sviryaeva, O. Yu. Ivanova, Andrey A. Zamyatnin, Konstantin G. Lyamzaev, V. B. Saprunova, Enno K. Ruuge, Natalia V. Sumbatyan, M. Yu. Vyssokikh, S.S. Klishin, Lidia V. Domnina, Ruben A. Simonyan
Publikováno v:
Biochemistry. Biokhimiia. 73(12)
Synthesis of cationic plastoquinone derivatives (SkQs) containing positively charged phosphonium or rhodamine moieties connected to plastoquinone by decane or pentane linkers is described. It is shown that SkQs (i) easily penetrate through planar, mi