Zobrazeno 1 - 10
of 1 172
pro vyhledávání: '"M. York"'
Autor:
Mahnaz Hosseinpour, Xinqi Xi, Ling Liu, Luis Malaver-Ortega, Laura Perlaza-Jimenez, Jihoon E. Joo, Harrison M. York, Jonathan Beesley, C. Elizabeth Caldon, Pierre-Antoine Dugué, James G. Dowty, Senthil Arumugam, Melissa C. Southey, Joseph Rosenbluh
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract DNA methylation is an epigenetic mark that plays a critical role in regulating gene expression. DNA methyltransferase (DNMT) inhibitors, inhibit global DNA methylation and have been a key tool in studies of DNA methylation. A major bottlenec
Externí odkaz:
https://doaj.org/article/4b5c73d6eb4c45e2af8ef4e38c8d4099
Autor:
M. R. Schwabe, A. W. Fleischer, R. K. Kuehn, S. Chaudhury, J. M. York, D. S. Sem, W. A. Donaldson, M. J. LaDu, K. M. Frick
Publikováno v:
Frontiers in Aging Neuroscience, Vol 16 (2024)
IntroductionAlzheimer’s disease (AD) prevalence and severity are associated with increased age, female sex, and apolipoprotein E4 (APOE4) genotype. Although estrogen therapy (ET) effectively reduces symptoms of menopause including hot flashes and a
Externí odkaz:
https://doaj.org/article/2fa33de520194c4b98365d1a00ebbd49
Autor:
Emma M. Palmer, Caleb A. Snoddy, Peyton M. York, Sydney M. Davis, Madelyn F. Hunter, Natraj Krishnan
Publikováno v:
Biology, Vol 13, Iss 11, p 854 (2024)
Over the past two decades, Drosophila melanogaster has proven to be successful in modeling the polyglutamine (polyQ) (caused by CAG repeats) family of neurodegenerative disorders, including the faithful recapitulation of pathological features such as
Externí odkaz:
https://doaj.org/article/bc0278a04cb44791b94d97d96225f9ad
Autor:
Deebika Balu, Ana C. Valencia-Olvera, Ashwini Deshpande, Saharsh Narayanam, Sravya Konasani, Shreya Pattisapu, Jason M. York, Gregory R. J. Thatcher, Mary Jo LaDu, Leon M. Tai
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
Increasing evidence suggests that female individuals have a higher Alzheimer’s disease (AD) risk associated with post-menopausal loss of circulating estradiol (E2). However, clinical data are conflicting on whether E2 lowers AD risk. One potential
Externí odkaz:
https://doaj.org/article/c8dfbdee1ee04ce49baa722ee97324c7
Autor:
Darrin M. York
Publikováno v:
ACS Physical Chemistry Au, Vol 3, Iss 6, Pp 478-491 (2023)
Externí odkaz:
https://doaj.org/article/968b35d0d5964689b7a1d39cd073c723
Autor:
Harrison M. York, Kunaal Joshi, Charles S. Wright, Laura Z. Kreplin, Samuel J. Rodgers, Ullhas K. Moorthi, Hetvi Gandhi, Abhishek Patil, Christina A. Mitchell, Srividya Iyer-Biswas, Senthil Arumugam
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Endosomal maturation is critical for robust and timely cargo transport to specific cellular compartments. The most prominent model of early endosomal maturation involves a phosphoinositide-driven gain or loss of specific proteins on individu
Externí odkaz:
https://doaj.org/article/b82edde0750c4c3ea2517f10c34927f4
Autor:
Brandon J. Weihs, Zhou Tang, Zezhong Tian, Deborah Jo Heuschele, Aftab Siddique, Thomas H. Terrill, Zhou Zhang, Larry M. York, Zhiwu Zhang, Zhanyou Xu
Publikováno v:
Plant Phenomics, Vol 6 (2024)
Background: Root system architecture (RSA) is of growing interest in implementing plant improvements with belowground root traits. Modern computing technology applied to images offers new pathways forward to plant trait improvements and selection thr
Externí odkaz:
https://doaj.org/article/e4bab799f74a4eddb5312591d01e3f3d
Publikováno v:
Plant Phenomics, Vol 6 (2024)
Roots are essential for acquiring water and nutrients to sustain and support plant growth and anchorage. However, they have been studied less than the aboveground traits in phenotyping and plant breeding until recent decades. In modern times, root pr
Externí odkaz:
https://doaj.org/article/80f6b0b91909447986f65e2d10fee006
Publikováno v:
BMC Biology, Vol 21, Iss 1, Pp 1-16 (2023)
Abstract Background Some dendrobatid poison frogs sequester the toxin epibatidine as a defense against predators. We previously identified an amino acid substitution (S108C) at a highly conserved site in a nicotinic acetylcholine receptor β2 subunit
Externí odkaz:
https://doaj.org/article/be36abcc170643cebb887e77b4e7612b
Publikováno v:
Molecules, Vol 29, Iss 11, p 2703 (2024)
Rare tautomeric forms of nucleobases can lead to Watson–Crick-like (WC-like) mispairs in DNA, but the process of proton transfer is fast and difficult to detect experimentally. NMR studies show evidence for the existence of short-time WC-like guani
Externí odkaz:
https://doaj.org/article/7f2e69d09e234ee7aac28416522f80eb