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Specific T-cell immune responses against colony-forming cells including leukemic progenitor cells of AML patients were increased by immune checkpoint inhibition

Autor: Susanne Hofmann, Lars Bullinger, Jochen Greiner, M Wiesneth, Marlies Götz, Hartmut Döhner, Vanessa Schneider, Hubert Schrezenmeier

Publikováno v: Cancer Immunology, Immunotherapy. 69:629-640

The efficacy of immunotherapies in cancer treatment becomes more and more apparent not only in different solid tumors but also in hematological malignancies. However, in acute myeloid leukemia (AML), mechanisms to increase the efficacy of immunothera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f11a9bfa4423c8447fa53012a2471b6a
https://doi.org/10.1007/s00262-020-02490-2

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Granulocyte transfusions – bridging to allogeneic hematopoietic stem cell transplantation

Autor: Hartmut Döhner, Thanh Mai Nguyen, Mark Ringhoffer, Martin Bommer, Donald Bunjes, Peter Reinhardt, Stephan R Bohl, Ramin Lotfi, Sixten Körper, Stephanie von Harsdorf, Florian Kuchenbauer, M Wiesneth, Hubert Schrezenmeier, Irina Idler, Verena Wais, Katrina Scholl

Publikováno v: Leukemia & Lymphoma. 61:481-484

Patients with hematological malignancies undergoing intensive chemotherapy or due to their underlying disease often suffer from serious infections during neutropenia. One possibility of bridging ne...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa3748fa2a9f24e6b7c73c0f48f55079
https://doi.org/10.1080/10428194.2019.1660977

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Translation of a standardized manufacturing protocol for mesenchymal stromal cells: A systematic comparison of validation and manufacturing data

Autor: Hubert Schrezenmeier, Sølve Hellem, Pierre Layrolle, Cecilie Gudveig Gjerde, Ramin Lotfi, M Wiesneth, Aymen Bushra Ahmed, Markus Rojewski, Sixten Körper, Kamal Mustafa, Luc Sensebé, Elena Veronesi

Publikováno v: Cytotherapy

Background Many data are available on expansion protocols for mesenchymal stromal cells (MSCs) for both experimental settings and manufacturing for clinical trials. However, there is a lack of information on translation of established protocols for G

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e318c3d53f9fa2187295fefe79c9e70
https://doi.org/10.1016/j.jcyt.2019.03.001

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Gender, cholinesterase, platelet count and red cell count are main predictors of peripheral blood stem cell mobilization in healthy donors

Autor: Joannis Mytilineos, Hubert Schrezenmeier, Ansgar Schulz, Daniel Fürst, M Wiesneth, Sixten Körper, Peter Schauwecker, David Hauber, Peter Reinhardt, Donald Bunjes

Publikováno v: Vox Sanguinis. 114:275-282

Background and objectives Mobilization of CD34+ cells by stimulation with G-CSF shows considerable variation across stem cell donors. Upfront prediction of CD34+ cell counts in peripheral blood based on easily available steady-state parameters would

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c802ad4711097fac4b6962730e070488
https://doi.org/10.1111/vox.12754

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Donor lymphocyte infusion leads to diversity of specific T cell responses and reduces regulatory T cell frequency in clinical responders

Autor: Donald Bunjes, Hartmut Döhner, Susanne Hofmann, Michael Schmitt, Jochen Greiner, M Wiesneth, Marlies Götz

Publikováno v: International Journal of Cancer. 144:1135-1146

T cell responses against malignant cells play a major role in maintaining remission and prolonging overall survival in patients after allogeneic stem cell transplantation and donor lymphocyte infusion (DLI) due to graft-versus-leukemia effect. For be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5b56f57aed51c574175f896c7c470e60
https://doi.org/10.1002/ijc.31753

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Healthy donor hematopoietic stem cell mobilization with biosimilar granulocyte‐colony‐stimulating factor: safety, efficacy, and graft performance

Autor: Peter Reinhardt, Christian Seidl, Hubert Schrezenmeier, Heike Bialleck, Erhard Seifried, Arnd Schwebig, Sreekanth Gattu, Susanne Brauninger, Petra S. A. Becker, Beate Luxembourg, Halvard Bonig, Chrysanthi Tsamadou, Natalia Kaliakina, Pritibha Singh, Miriam Schulz, Joannis Mytilineos, M Wiesneth

Publikováno v: Transfusion. 56:3055-3064

BACKGROUND Biosimilar granulocyte-colony-stimulating factors (G-CSFs) have been available in the European Union since 2008, and Sandoz' biosimilar filgrastim was approved in the United States in March 2015 for all of the reference product's indicatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a043be3ffa6a24b87fb1f6327e5491d2
https://doi.org/10.1111/trf.13853

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Kommentar zur neuen 'Richtlinie zur Herstellung und Anwendung von hämatopoetischen Stammzellzubereitungen' vom 18. August 2014

Autor: M. Wiesneth

Publikováno v: Transfusionsmedizin - Immunhämatologie, Hämotherapie, Immungenetik, Zelltherapie. 5:192-198

Die neue „Richtlinie zur Herstellung und Anwendung von hamatopoetischen Stammzellzubereitungen“ definiert erstmals den Begriff „hamatopoetische Stammzellzubereitungen“ und fasst darunter die Stammzellzubereitungen aus peripherem Blut, Nabelsc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e1a70466b099c5e09b4290e9a869ef92
https://doi.org/10.1055/s-0035-1558108

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Acute myeloid leukemia with mutated nucleophosmin 1: an immunogenic acute myeloid leukemia subtype and potential candidate for immune checkpoint inhibition

Autor: Susanne Hofmann, Michael Schmitt, Hubert Schrezenmeier, Hartmut Döhner, Jochen Greiner, M Wiesneth, Lars Bullinger, Marlies Götz, Donald Bunjes

Publikováno v: Haematologica. 102(12)

Clinical and preclinical data suggest that acute myeloid leukemia (AML) with mutated nucleophosmin 1 ( NPM1 mut) might constitute an immunogenic leukemia subtype. In general, AML with NPM1 mut correlates with better prognosis, but the underlying mech

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82e9e2e8b430f4421bc7ec9771d382b6
https://pubmed.ncbi.nlm.nih.gov/28935849

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