Zobrazeno 1 - 10
of 407
pro vyhledávání: '"M. Wehr"'
Autor:
Matthias M. Wehr, Stella Marie Reamon-Buettner, Detlef Ritter, Jan Knebel, Monika Niehof, Sylvia E. Escher
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-14 (2024)
Abstract Next-generation risk assessment relies on mechanistic data from new approach methods, including transcriptome data. Various technologies, such as high-throughput targeted sequencing methods and microarray technologies based on hybridization
Externí odkaz:
https://doaj.org/article/11e16239a00c42b6a2cfd059b284d4dc
Substantiate a read-across hypothesis by using transcriptome data—A case study on volatile diketones
Autor:
Christina Drake, Matthias M. Wehr, Walter Zobl, Jeannette Koschmann, David De Lucca, Britta A. Kühne, Tanja Hansen, Jan Knebel, Detlef Ritter, Jan Boei, Harry Vrieling, Annette Bitsch, Sylvia E. Escher
Publikováno v:
Frontiers in Toxicology, Vol 5 (2023)
This case study explores the applicability of transcriptome data to characterize a common mechanism of action within groups of short-chain aliphatic α-, β-, and γ-diketones. Human reference in vivo data indicate that the α-diketone diacetyl induc
Externí odkaz:
https://doaj.org/article/ef322cf5e85e456eb141e4eefa521a86
Autor:
Lise Lecointre, M. Wehr, Cherif Akladios, Thomas Boisramé, J.-J. Baldauf, L. Schwartz, H. Schneider, Emilie Faller
Publikováno v:
Gynécologie Obstétrique Fertilité & Sénologie. 50:33-39
Resume Objectif Demontrer la faisabilite de l’hysterectomie par voie cœlioscopique en ambulatoire en France par l’evaluation de la qualite de vie postoperatoire. Methodes Nous avons mene une etude prospective randomisee monocentrique en France e
Autor:
Nanette G, Vrijenhoek, Matthias M, Wehr, Steven J, Kunnen, Lukas S, Wijaya, Giulia, Callegaro, Martijn J, Moné, Sylvia E, Escher, Bob, Van de Water
Publikováno v:
ALTEX : Alternatives to Animal Experimentation
ALTEX
ALTEX
Chemical read-across is commonly evaluated without particular knowledge of the biological mechanisms leading to observed adverse outcomes in vivo. Integrating data that indicate shared modes of action in humans will strengthen read-across cases. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09e2256765890ee51972b634035aa790
http://hdl.handle.net/1887/3279365
http://hdl.handle.net/1887/3279365
Autor:
M. Wehr, Martijn Rooseboom, Peter J. Boogaard, Sylvia Escher, Andreas Karwath, Satinder S. Sarang
Publikováno v:
Regulatory Toxicology and Pharmacology 128 (2022)
Regulatory Toxicology and Pharmacology, 128
Regulatory Toxicology and Pharmacology, 128
Respiratory irritation is an important human health endpoint in chemical risk assessment. There are two established modes of action of respiratory irritation, 1) sensory irritation mediated by the interaction with sensory neurons, potentially stimula
Autor:
C. Drake, W. Zobl, M. Wehr, J. Koschmann, D. De Luca, B.A. Kühne, H. Vrieling, J. Boei, T. Hansen, S.E. Escher
Publikováno v:
Toxicology Letters. 368:S253
Autor:
W. Zobl, M. Wehr, C. Drake, J.P. Schimming, D. Pellegrino-Coppola, J. Blum, L. Santos Capinha, E. Davilo, P. Walker, B. Islam, L. Tolosa, P. Jennings, B.M. van Vugt-Lussenburg, J.J. Boei, M. Leist, B. van de Water, C. Fisher, S.E. Escher
Publikováno v:
Toxicology Letters. 368:S254
Publikováno v:
Toxicology Letters. 368:S85
Autor:
M, Wehr, L, Lecointre, H, Schneider, L, Schwartz, E, Faller, T, Boisramé, J-J, Baldauf, C, Akladios
Publikováno v:
Gynecologie, obstetrique, fertilitesenologie. 50(1)
To demonstrate the feasibility of outpatient laparoscopic hysterectomy using the assessment of post-operative quality of life.A prospective randomized single-center trial was performed in France between 2013 and 2016. A total of 42 patients needed la
Publikováno v:
Toxicology Letters. 350:S128