Výsledky vyhledávání - "M. Wade Calcutt"

Akademický článek

Carnitine consumption and effect of oral supplementation in human pulmonary arterial hypertension: A pilot study

Autor: Evan L. Brittain, Alisha Lindsey, Kelly Burke, Vineet Agrawal, Ivan Robbins, Meredith Pugh, M. Wade Calcutt, Ravi Mallugari, James West, Hui Nian, Anna R. Hemnes

Publikováno v: Pulmonary Circulation, Vol 14, Iss 3, Pp n/a-n/a (2024)

Abstract Carnitine is required to transport fatty acid across the mitochondrial membrane to undergo beta oxidation. In addition to disorders of fatty acid metabolism, a relative carnitine deficiency has been reported in pulmonary arterial hypertensio

Externí odkaz: https://doaj.org/article/33158e9ed2564a83b0aa9a752705262b

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Akademický článek

Tumor therapy by targeting extracellular hydroxyapatite using novel drugs: A paradigm shift

Autor: Mohammed N. Tantawy, J. Oliver McIntyre, Fiona Yull, M. Wade Calcutt, Dmitry S. Koktysh, Andrew J. Wilson, Zhongliang Zu, Jeff Nyman, Julie Rhoades, Todd E. Peterson, Daniel Colvin, Lisa J. McCawley, Jerri. M. Rook, Barbara Fingleton, Marta Ann Crispens, Ronald D. Alvarez, John C. Gore

Publikováno v: Cancer Medicine, Vol 13, Iss 3, Pp n/a-n/a (2024)

Abstract Background It has been shown that tumor microenvironment (TME) hydroxyapatite (HAP) is typically associated with many malignancies and plays a role in tumor progression and growth. Additionally, acidosis in the TME has been reported to play

Externí odkaz: https://doaj.org/article/9b560d0bef2f4ba0a581210d8528af70

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Akademický článek

Association of alpha-aminoadipic acid with cardiometabolic risk factors in healthy and high-risk individuals

Autor: Stacy Desine, Curtis L. Gabriel, Holly M. Smith, Olivia R. Antonetti, Chuan Wang, M. Wade Calcutt, Amanda C. Doran, Heidi J. Silver, Sangeeta Nair, James G. Terry, John Jeffrey Carr, MacRae F. Linton, Jonathan D. Brown, John R. Koethe, Jane F. Ferguson

Publikováno v: Frontiers in Endocrinology, Vol 14 (2023)

IntroductionPlasma levels of the metabolite alpha-aminoadipic acid (2-AAA) have been associated with risk of type 2 diabetes (T2D) and atherosclerosis. However, little is known about the relationship of 2-AAA to other cardiometabolic risk markers in

Externí odkaz: https://doaj.org/article/8f643703c27845e5a9c8cde550bcd571

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Akademický článek

Cystathionine γ-lyase exacerbates Helicobacter pylori immunopathogenesis by promoting macrophage metabolic remodeling and activation

Publikováno v: JCI Insight, Vol 7, Iss 12 (2022)

Macrophages play a crucial role in the inflammatory response to the human stomach pathogen Helicobacter pylori, which infects half of the world’s population and causes gastric cancer. Recent studies have highlighted the importance of macrophage imm

Externí odkaz: https://doaj.org/article/19c8a2f445654133870ff2cc83d6103c

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Akademický článek

Iron deficiency linked to altered bile acid metabolism promotes Helicobacter pylori–induced inflammation–driven gastric carcinogenesis

Publikováno v: The Journal of Clinical Investigation, Vol 132, Iss 10 (2022)

Gastric carcinogenesis is mediated by complex interactions among Helicobacter pylori, host, and environmental factors. Here, we demonstrate that H. pylori augmented gastric injury in INS-GAS mice under iron-deficient conditions. Mechanistically, thes

Externí odkaz: https://doaj.org/article/7d198f5f9fa7400583ab84388b9c0680

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Akademický článek

Monolayer autoxidation of arachidonic acid to epoxyeicosatrienoic acids as a model of their potential formation in cell membranes

Autor: James A. Weiny, William E. Boeglin, M. Wade Calcutt, Donald F. Stec, Alan R. Brash

Publikováno v: Journal of Lipid Research, Vol 63, Iss 1, Pp 100159- (2022)

In light of the importance of epoxyeicosatrienoic acids (EETs) in mammalian pathophysiology, a nonenzymatic route that might form these monoepoxides in cells is of significant interest. In the late 1970s, a simple system of arranging linoleic acid mo

Externí odkaz: https://doaj.org/article/f93c269fb54242c89f2ac0e7c0d05dc4

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Akademický článek

Knock-Out of DHTKD1 Alters Mitochondrial Respiration and Function, and May Represent a Novel Pathway in Cardiometabolic Disease Risk

Autor: Chuan Wang, M. Wade Calcutt, Jane F. Ferguson

Publikováno v: Frontiers in Endocrinology, Vol 12 (2021)

Cardiometabolic disease affects the majority of individuals worldwide. The metabolite α-aminoadipic acid (2-AAA) was identified as a biomarker of Type 2 Diabetes (T2D). However, the mechanisms underlying this association remain unknown. DHTKD1, a ce

Externí odkaz: https://doaj.org/article/d89bc734312a4eefb8c914b99312bf57

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Akademický článek

Hypusination Orchestrates the Antimicrobial Response of Macrophages

Autor: Alain P. Gobert, Jordan L. Finley, Yvonne L. Latour, Mohammad Asim, Thaddeus M. Smith, Thomas G. Verriere, Daniel P. Barry, Margaret M. Allaman, Alberto G. Delagado, Kristie L. Rose, M. Wade Calcutt, Kevin L. Schey, Johanna C. Sierra, M. Blanca Piazuelo, Raghavendra G. Mirmira, Keith T. Wilson

Publikováno v: Cell Reports, Vol 33, Iss 11, Pp 108510- (2020)

Summary: Innate responses of myeloid cells defend against pathogenic bacteria via inducible effectors. Deoxyhypusine synthase (DHPS) catalyzes the transfer of the N-moiety of spermidine to the lysine-50 residue of eukaryotic translation initiation fa

Externí odkaz: https://doaj.org/article/c676099b79ac40018987909502fd92db

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