Zobrazeno 1 - 10
of 172
pro vyhledávání: '"M. WENSVEEN"'
Publikováno v:
Cells, Vol 13, Iss 17, p 1464 (2024)
Natural Killer (NK) cells, integral components of the innate immune system, play a crucial role in the protection against intracellular threats. Their cytotoxic power requires that activation is tightly controlled, and in this, they take a unique pos
Externí odkaz:
https://doaj.org/article/ba56723cc514464eab10cd640ac20e7c
Publikováno v:
International Journal of Cardiology: Heart & Vasculature, Vol 49, Iss , Pp 101308- (2023)
Background: Peripheral arterial disease (PAD) reduces functional capacity and raises cardiovascular risks, but underdiagnosis is common, resulting in less comprehensive care than other cardiovascular conditions. While diabetes has long been viewed as
Externí odkaz:
https://doaj.org/article/e0a810bb159844bf8752c772aea09159
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Natural killer (NK) cells play an important role in the early defense against tumors and virally infected cells. Their function is thought to be controlled by the balance between activating and inhibitory receptors, which often compete for the same l
Externí odkaz:
https://doaj.org/article/3e500e3a98db444b83cf53a0f316a0b2
Autor:
Inga Kavazović, Christoforos Dimitropoulos, Dora Gašparini, Mari Rončević Filipović, Igor Barković, Jan Koster, Niels A. Lemmermann, Marina Babić, Đurđica Cekinović Grbeša, Felix M. Wensveen
Publikováno v:
Cell Reports, Vol 42, Iss 4, Pp 112395- (2023)
Summary: Memory CD8 T cells play an important role in the protection against breakthrough infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Whether the route of antigen exposure impacts these cells at a functional level is
Externí odkaz:
https://doaj.org/article/00ba778f37904e38a0265f3620a2db25
Publikováno v:
Metabolites, Vol 13, Iss 2, p 153 (2023)
In their aspiration to become healthy, people are known to follow extreme diets. However, the acute impact on organs regulating systemic metabolism is not well characterized. Here, we investigated the acute impact of six extreme diets on the liver in
Externí odkaz:
https://doaj.org/article/dcab13eff39544748fbf1f929965714f
Autor:
Anne W. J. Martens, Inga Kavazović, Mia Krapić, Su Min Pack, Ramon Arens, Aldo Jongejan, Perry D. Moerland, Eric Eldering, Gerritje J. W. van der Windt, Felix M. Wensveen, Fleur S. Peters, Arnon P. Kater
Publikováno v:
Leukemia, 1-11. Nature Publishing Group
STARTPAGE=1;ENDPAGE=11;ISSN=0887-6924;TITLE=Leukemia
Leukemia, 37, 606-616. SPRINGERNATURE
Leukemia
Volume 37
STARTPAGE=1;ENDPAGE=11;ISSN=0887-6924;TITLE=Leukemia
Leukemia, 37, 606-616. SPRINGERNATURE
Leukemia
Volume 37
T-cell dysregulation in chronic lymphocytic leukemia (CLL) associates with low response rates to autologous T cell-based therapies. How CLL affects antigen-specific T-cell responses remains largely unknown. We investigated (epi)genetic and functional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4913b98a4d25cb7dce2df04195881459
https://doi.org/10.1038/s41375-023-01817-z
https://doi.org/10.1038/s41375-023-01817-z
Autor:
Inga Kavazović, Hongya Han, Giulia Balzaretti, Erik Slinger, Niels A W Lemmermann, Anja Ten Brinke, Doron Merkler, Jan Koster, Yenan T Bryceson, Niek de Vries, Stipan Jonjić, Paul L Klarenbeek, Bojan Polić, Eric Eldering, Felix M Wensveen
Publikováno v:
PLoS Biology, Vol 18, Iss 3, p e3000648 (2020)
The memory CD8 T-cell pool must select for clones that bind immunodominant epitopes with high affinity to efficiently counter reinfection. At the same time, it must retain a level of clonal diversity to allow recognition of pathogens with mutated epi
Externí odkaz:
https://doaj.org/article/44f011a2567046b1a91de7cf857789c9
Publikováno v:
Viruses, Vol 13, Iss 11, p 2245 (2021)
Sickness behavior is the common denominator for a plethora of changes in normal behavioral routines and systemic metabolism during an infection. Typical symptoms include temperature, muscle weakness, and loss of appetite. Whereas we experience these
Externí odkaz:
https://doaj.org/article/bbaf057ac73d47378c3bb6fcc1da1fea
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Effector and memory CD8 T cells have an intrinsic difference in the way they must approach antigen; effector cells need to address the pathogen at hand and therefore favor outgrowth of only high-affinity clones. In contrast, the memory pool benefits
Externí odkaz:
https://doaj.org/article/aec619f1370949d48a2a8796e03f4b73
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
NKG2D is an activating receptor that is mostly expressed on cells of the cytotoxic arm of the immune system. Ligands of NKG2D are normally of low abundance, but can be induced in virtually any cell in response to stressors, such as infection and onco
Externí odkaz:
https://doaj.org/article/2d0b0e4da5b7482ca8be7b2de17673b6