Zobrazeno 1 - 8 of 8 pro vyhledávání: '"M. W. Rixon"'
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POS0094 ALPN-303, AN ENGINEERED DUAL BAFF/APRIL ANTAGONIST, POTENTLY INHIBITS PATHOGENIC LYMPHOCYTE SUBSETS AND FUNCTION IN B-CELL- AND ANTIBODY-RELATED PRECLINICAL MODELS
Autor: S. R. Dillon, K. E. Lewis, S. Mudri, K. Kleist, L. Griffin, L. S. Evans, J. Bhandari, L. Garrett, M. A. Seaberg, N. Wang, A. Chunyk, D. Ardourel, L. Hebb, M. F. Wolfson, M. W. Rixon, P. Holland, S. L. Peng
Publikováno v: Annals of the Rheumatic Diseases. 81:268.2-269
BackgroundB-cell activating factor (BAFF) and a proliferation-inducing ligand (APRIL) are tumor necrosis factor (TNF) superfamily members that bind TACI (transmembrane activator and CAML interactor), BCMA (B-cell maturation antigen), and/or BAFF-R on
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3e69c578288ff200b34f751ce75bf75f
https://doi.org/10.1136/annrheumdis-2022-eular.771
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2
OP0039 ALPN-303, AN ENHANCED, POTENT DUAL BAFF/APRIL ANTAGONIST ENGINEERED BY DIRECTED EVOLUTION FOR THE TREATMENT OF SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) AND OTHER B CELL-RELATED AUTOIMMUNE DISEASES
Autor: S. Mudri, J. Hillson, C. Gudgeon, L. S. Evans, R. Wang, M. A. Seaberg, D. Demonte, R. Sanderson, D. Ardourel, M. W. Rixon, Steven D. Levin, K. Kleist, S. L. Peng, M. F. Wolfson, J. Kuijper, Katherine E. Lewis, Stacey R. Dillon, J. Yang, J. Bhandari, S. Bort
Publikováno v: Annals of the Rheumatic Diseases. 80:21.2-21
Background:BAFF and APRIL are TNF superfamily members that form homo- and heteromultimers that bind TACI and BCMA on B cells; BAFF also binds BAFF-R. BAFF and APRIL support B cell development, differentiation, and survival, particularly for plasmabla
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ef4e2273ed2109e7f533a42698edcd4d
https://doi.org/10.1136/annrheumdis-2021-eular.727
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4
Preferential use of a H chain V region in antitumor-associated glycoprotein-72 monoclonal antibodies
Autor: M W Rixon, B B Gourlie, D A Kaplan, J Schlom, P S Mézes
Publikováno v: The Journal of Immunology. 151:6559-6568
The DNA sequence of the mouse H chain V regions from five hybridomas directed against the human tumor Ag tumor-associated glycoprotein-72 (TAG-72) have been determined. This includes a previously determined VH gene sequence from a first-generation an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ce9b4ee275c99db787e32a43faabb0de
https://doi.org/10.4049/jimmunol.151.11.6559
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5
Preferential use of a H chain V region in antitumor-associated glycoprotein-72 monoclonal antibodies
Autor: M W, Rixon, B B, Gourlie, D A, Kaplan, J, Schlom, P S, Mézes
Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 151(11)
The DNA sequence of the mouse H chain V regions from five hybridomas directed against the human tumor Ag tumor-associated glycoprotein-72 (TAG-72) have been determined. This includes a previously determined VH gene sequence from a first-generation an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4ee9cee6cdb8f577dae19366f3f281ff
https://pubmed.ncbi.nlm.nih.gov/8245485
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6
A fetal globin gene mutation in A gamma nondeletion hereditary persistence of fetal hemoglobin increases promoter strength in a nonerythroid cell
Autor: M W Rixon, R E Gelinas
Publikováno v: Molecular and Cellular Biology. 8:713-721
Single base substitutions have been identified in the promoter regions of A gamma-globin genes from individuals with certain types of nondeletion A gamma hereditary persistence of fetal hemoglobin (HPFH). The presence of these mutations is closely as
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5e572f61696569107df665abbf469ec2
https://doi.org/10.1128/mcb.8.2.713
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7
A Fetal Globin Gene Mutation in Aϒ Nondeletion Hereditary Persistence of Fetal Hemoglobin Increases Promoter Strength in a Nonerythroid Cell
Autor: M W, Rixon, R E, Gelinas
Publikováno v: Molecular and Cellular Biology. 8:713-721
Single base substitutions have been identified in the promoter regions of A gamma-globin genes from individuals with certain types of nondeletion A gamma hereditary persistence of fetal hemoglobin (HPFH). The presence of these mutations is closely as
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daaff137e731210580d93c6044369fac
https://doi.org/10.1128/mcb.8.2.713-721.1988
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