Discovery of new anti-cancer agents

Autor: M W, Lobbezoo, M R, Krul, H M, Pinedo

Publikováno v: Forum (Genoa, Italy). 9(3 Suppl 3)

Anticancer drug discovery has changed fundamentally owing to recent progress in basic research. Historically, the discovery of potential new drugs for the treatment of cancer has largely relied on large-scale random screening. Although several useful

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2c47b7e2a851bfa68d72fd1850cab5ed
https://pubmed.ncbi.nlm.nih.gov/10607846

Abstracts of lectures symposium disposition and delivery of peptide drugs

Autor: H. M. Pinedo, Rokus A. de Zeeuw, E. A. Hogendoorn, R. van Gijn, S. V. Rose, M. Barnard, H. H. van den Broek, O. A. G. J. van der Houwen, H. M. Ruijten, P. De Moerloose, M. A. J. van Opstal, A. J. Baars, A. Bult, L. G. D. Lammerts van Bueren, K. Ensing, E. v.d. Heeft, J. H. G. Jonkman, W. P. van Bennekom, L. P. C. P. Delbressine, R. W. Frei, H. J. van Rossum, W. G. in 't Hout, C. van de Water, J. J. M. de Clippeleir, Ben F. H. Drenth, K. Sierat, U. A. Th. Brinkman, N. Haagsma, G. de Groot, Naeem Hasan Khan, E. H. Groot Bramel, D. J. K. van der Stel, C. P. Groen, W. J. M. Underberg, P. S. L. Janssen, D. E. M. M. Vendrig, J. A. De Schutter, P. A. Maessen, M. J. M. v. Zeeland, A. Mekking, P. J. M. Kwakman, J. H. N. van den Berg, A. L. L. Duchateau, J. K. van den Bergh-Swart, H. Vanderhaeghe, P. A. T. A. Melgers, M. W. Lobbezoo, C. E. Goewie, H. de Bree, N. G. F. M. Lammers, H. M. Steinbuch, P. W. Zoontjes, R.A. de Zeeuw, B. C. Goverde, J. Hempenius, A. S. Horn, D. A. Bloemhof, E. Roets, O. A. M. Brockhoff, R. L. A. E. Hanmelinck, M. Otagiri, P. M. J. Coenegracht, D. A. Doornbos, F. J. Spruit, T. K. Gerding, Th. Cachet, O. E. de Noord, Karla G. Feitsma, S. C. M. Lubbers, H. van Blitterswijk, O. R. Leeuwenkamp, R. W. Stephany, M. P. van Berkel, S. L. Verweij, G. J. de Jong, B. F. H. Drenth, W. J. F. van der Vijgh, P. Krabbenborg, J.M. van den Berg, H. van Beek, O. Beckers, A. C. A. Paalman, F. M. Kaspersen, W. J. F. vd Vijh, N. Lammers, L. A. van Ginkel, J. Hoogmartens, P. J. H. Hendricks, K. B. Mross, T. A. Verstappen, J. Teeuwsen, J. J. M. Holthuis, J. Tipker, G. W. M. v. Aalst, P. R. Kootstra, J. W. v. Nispen, Jos H. Beijnen, F. Elferink, B. C. A. Tepas, A. Blokland, A. J. P. M. de Jong

Publikováno v: Pharmaceutisch Weekblad. 10:30-50

A number of different processes clear peptides from the circulation. These will be described and illustrated using examples from a range of peptide hormones and analogues.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3a35996bee6439b23537fbfcc6afbeba
https://doi.org/10.1007/bf01966433

Human tumor xenografts in the nude mouse and their value as test models in anticancer drug development (review)

Autor: B, Winograd, E, Boven, M W, Lobbezoo, H M, Pinedo

Publikováno v: In vivo (Athens, Greece). 1(1)

In an attempt to increase the predictability of preclinical antitumor testing, the value of human tumor lines in immune-deficient nude mice is assessed by reviewing the relevant literature. This test model is rather elaborate due to the nature of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::67aa729039e486b8ca288343f1f8c639
https://pubmed.ncbi.nlm.nih.gov/2979758

IN VITRO STUDIES ON THE OPIATE RECEPTOR AFFINITY OF FENTANYL ANALOGUES

Autor: M. W. Lobbezoo, I. van Wijngaarden, W. Soudijn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1c9ab453161294bdb4bf42d8d3c27ae8
https://doi.org/10.1016/b978-0-08-026390-8.50010-8

Opiate receptor binding of nicomorphine and its hydrolysis products in rat brain

Autor: Hans H. Van Rooy, Ineke Van Wijngaarden, W. Soudijn, M. W. Lobbezoo

Publikováno v: European journal of pharmacology. 82(3-4)

In vitro receptor binding studies with paraoxon treated rat brain membranes, and stability studies using HPLC analysis, showed a negligible opiate receptor affinity for the morphinomimetic agent nicomorphine and its hydrolysis product 3-nicotinoylmor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5612daf794f037eb299640b9352da64
https://pubmed.ncbi.nlm.nih.gov/6290237