Výsledky vyhledávání - "M. W. Honders"

Akademický článek

Microarray Gene Expression Analysis to Evaluate Cell Type Specific Expression of Targets Relevant for Immunotherapy of Hematological Malignancies.

Autor: M J Pont, M W Honders, A N Kremer, C van Kooten, C Out, P S Hiemstra, H C de Boer, M J Jager, E Schmelzer, R G Vries, A S Al Hinai, W G Kroes, R Monajemi, J J Goeman, S Böhringer, W A F Marijt, J H F Falkenburg, M Griffioen

Publikováno v: PLoS ONE, Vol 11, Iss 5, p e0155165 (2016)

Cellular immunotherapy has proven to be effective in the treatment of hematological cancers by donor lymphocyte infusion after allogeneic hematopoietic stem cell transplantation and more recently by targeted therapy with chimeric antigen or T-cell re

Externí odkaz: https://doaj.org/article/050040751d6c476f9999813834a75aa9

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In vitro-induced resistance to the deoxycytidine analogues cytarabine (AraC) and 5-aza-2′-deoxycytidine (DAC) in a rat model for acute myeloid leukemia is mediated by mutations in the deoxycytidine kinase (dck) gene

Autor: R. Willemze, M. W. Honders, A. P. A. Stegmann, J. E. Landegent, A. Hagemeijer, B. Hoebee

Publikováno v: Annals of Hematology. 71:41-47

The deoxycytidine kinase (dck) gene encodes the enzyme responsible for the metabolic activation of the antileukemic drugs cytosine arabinoside (AraC) and 5-aza-2'-deoxycytidine (decitabine, DAC). The dck locus was analyzed at the chromosomal and the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b1fd927693f4b0f08140fe9653638c0
https://doi.org/10.1007/bf01696231

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Abstracts of oral presentations

Autor: R. Boulieu, A. Lenoir, J. F. Mornex, C. Bohman, J. Balzarini, P. Wigerinck, A. Aerschot, P. Herdewijn, Erik Clercq, S. Brosh, E. Zoref-Shani, O. Sperling, E. Danziger, Y. Sidi, Y. Bromberg, Renate Burgemeister, Elke Rötzer, Wolf Gutensohn, G. P. Connolly, P. J. Harrison, R. B. Diasio, Z. Lu, R. Zhang, U. Gresser, W. Gutensohn, R. Resta, L. F. Thompson, F. Javaux, M. F. Vincent, G. Berghe, I. Kamilli, R. Rauch, D. Hahn, C. W. Keuzenkamp-Jansen, R. A. Abreu, J. P. M. Bökkerink, M. A. H. Heijden, M. Löffler, C. Becker, E. Wegerie, M. Marcussen, K. Overgaard-Hansen, H. Klenow, A. M. Marinaki, E. H. Harley, M. B. McBride, H. A. Simmonds, F. Moro, J. S. Cameron, C. S. Ogg, D. G. Williams, S. Rigden, G. Haycock, M. E. Miranda, J. G. Puig, F. A. Mateos, J. O. Vázquez, V. W. T. Ruiz Haperen, G. Veerman, J. B. Vermorken, G. J. Peters, C. L. Wilt, P. Noordhuis, K. Smid, H. M. Pinedo, C. Salerno, A. Lomonte, O. Giardini, C. Crifo, R. T. Smolenski, M. H. Yacoub, A. M. -L. Seymour, A. P. A. Stegmann, M. W. Honders, R. Willemze, J. E. Landegent, E. H. Stet, G. M. Vogels-Mentink, L. H. J. Lambooy, J. M. F. Trijbels, R. J. Torres, M. G. Tozzi, R. Pesi, M. Turriani, S. Allegrini, M. Camici, P. L. Ipata, A. A. Berg, J. R. Meinsma, H. Lenthe, A. H. Gennip, A. B. P. Kuilenburg, N. G. G. M. Abeling, H. D. Bakker, R. J. Slingerland, F. Bergh, R. L. Sabina

Publikováno v: Pharmacy World & Science. 15:F7-F14

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::998f79b3fc5c41061e4d3e16542225b7
https://doi.org/10.1007/bf02297670

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A novel RT-PCR-based protein activity truncation assay for direct assessment of deoxycytidine kinase in small numbers of purified leukemic cells

Autor: Renee M.Y. Barge, Marjan J. T. Veuger, Roelof Willemze, J. E. Landegent, M. W. Honders

Publikováno v: Leukemia. 14(9)

In vitro studies have demonstrated that deoxycytidine kinase (dCK) plays a crucial role in the mechanism of resistance to cytarabine (AraC). The resistant phenotype in vitro is always a result of mutational inactivation of dCK, leading to defects in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c6abbe936a42918a71dd11d90300b55
https://pubmed.ncbi.nlm.nih.gov/11368449

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High incidence of alternatively spliced forms of deoxycytidine kinase in patients with resistant acute myeloid leukemia

Autor: M J, Veuger, M W, Honders, J E, Landegent, R, Willemze, R M, Barge

Publikováno v: Blood. 96(4)

Deficiency of functional deoxycytidine kinase (dCK) is a common characteristic for in vitro resistance to cytarabine (AraC). To investigate whether dCK is also a target for induction of AraC resistance in patients with acute myeloid leukemia (AML), w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::aa17c4a8e9eb56c1f277fc66dfa21ba7
https://pubmed.ncbi.nlm.nih.gov/10942400

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Mechanisms of Acquired ARA-C and DAC Resistance in Acute Myeloid Leukemia (AML): Development of a Model for the Study of Mutational Loss of Deoxycytidine Kinase (DCK) Activity

Autor: A. P. A. Stegmann, M. W. Honders, R. Willemze, J. E. Landegent

Publikováno v: Acute Leukemias V ISBN: 9783642789090

Complex and largely unknown mechanisms determine whether sufficient cyto-reduction occurs following chemotherapy for acute myeloid leukemia. The reasons for failure of induction treatment are related to patients’ age. With the current supportive ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::faa1a00c40e3f39c9e975c2df13667b4
https://doi.org/10.1007/978-3-642-78907-6_14

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