The Comparative Pharmacodynamics of Remifentanil and Its Metabolite, GR90291, in a Rat Electroencephalographic Model

Autor: Josy M. Gubbens-Stibbe, Eugene H. Cox, M. W. E. Langemeijer, Meindert Danhof, Keith T. Muir

Publikováno v: Anesthesiology. 90:535-544

Background The purpose of this study was to investigate the in vivo pharmacodynamics and the pharmacodynamic interactions of remifentanil and its major metabolite, GR90291, in a rat electroencephalographic model. Methods Remifentanil and GR90291 were

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https://doi.org/10.1097/00000542-199902000-00030

[Untitled]

Autor: Eugene H. Cox, Meindert Danhof, E Tukker, Victorine S. Koster, Catherijne A. J. Knibbe, Han J. M. Langemeijer, M. W. E. Langemeijer, Loraine Lie-A-Huen, Rogier Lange, Paul F. M. Kuks

Publikováno v: Pharmaceutical Research. 15:442-448

Purpose. The influence of different intravenous formulations on the pharmacokinetics and pharmacodynamics of propofol was investigated using the effect on the EEG (11.5-30 Hz) as pharmacodynamic endpoint.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dd649474a88323d98d7893b243ba4951
https://doi.org/10.1023/a:1011980432646

Abstracts of papers Pharmacological Meeting

Autor: W. A. Bax, P. R. Saxena, Gerreke Ph. Biewenga, Jan Jong, Aalt Bast, Pauline G. M. Bloemen, Maria C. Tweel, Paul A. J. Henricks, Ferdi Engels, Frans P. Nijkamp, H. E. Molewijk, A. M. Poel, B. Olivier, M. R. Briejer, J. A. J. Schuurkes, L. M. A. Akkermans, T. A. Bruning, M. G. C. Hendriks, P. C. Chang, E. A. P. Kuypers, P. A. Zwieten, S. L. T. Cappendijk, R. Vries, M. R. Dzoljic, J. A. Bouwknecht, F. R. L. Crijns, M. S. P. Huijberts, H. A. J. Struijker Boudier, A. C. Nieuwenhuijzen Kruzeman, B. H. R. Wolffenbuttel, L. M. Lannov, A. H. J. Danser, R. G. Schoemakef, M. A. D. H. Schalekamp, Xiao Y. Du, Regien G. Schoemaker, Pramod R. Saxena, E. A. Dubois, H. D. Batink, M. Pfaffendorf, E. A. Roven, I. M. Garrelds, C. Graaf-in 't Veld, F. J. Ziilstra, A. P. H. Jansen, R. Gerth Wijk, B. C. G. Gho, R. G. Schoemaker, C. v. d. Lee, H. S. Sharma, P. D. Verdouw, L. Groenink, J. Gugten, T. J. J. Zethof, P. Hasselaar, J. W. C. M. Jansen, J. J. J. Giezen, G. H. Dreteler, A. Hulkenberq, J. H. Reinders, G. P. Toorop, A. H. J. Herremans, T. H. Hijzen, J. L. Slangen, E. M. Hessel, A. J. M. Oosterhout, C. Hofstra, J. Garssen, H. Loveren, H. F. J. Savelkoul, F. P. Nijkamp, Thorwald Hol, Jan M. Ree, Berry M. Spruijt, B. C. P. Hüsken, P. A. Zwieren, E. A. J. Kalkman, K. L. Kam, C. W. Keuzenkamp-Jansen, R. A. Abreu, J. P. M. Bökkerink, M. A. H. Heijden, J. M. F. Trijbels, A. D. Kraneveld, T. L. Buckley, Y. Schaik, A. Sj. Koster, R. A. A. Mathôt, B. C. F. M. Aarsen, M. W. E. Langemeijer, A. P. Ijzerman, M. Danhof, Inqe C. M. Mohede, Antoon J. M. Oosterhout, M. Monshouwer, R. F. Witkamp, S. M. Nijmeijer, A. S. J. P. A. M. Miert, J. Oosting, B. J. A. Janssen, A. J. Pijl, A. C. Wal, M. -J. Mathy, W. M. Pruimboom, A. P. M. Dijk, C. J. A. M. Tak, I. L. Bonta, J. H. P. Wilson, D. J. Bac, F. J. Zijlstra, G. Sadeghi Hashjin, G. Folkerts, P. A. J. Henricks, R. E. Santing, Y. Pasman, C. G. Olymulder, A. F. Roffel, J. Zaaqsma, H. Meurs, Heleen Scheerens, Theresa L. Buckley, Henk Loveren, H. Sipma, M. Duin, A. Hertog, A. Nelemans, J. Smit, R. P. Coppes, A. Geurtsen, J. Zaagsma, M. J. Smit, R. Leurs, A. Bast, H. Timmerman, F. R. M. Stassen, J. G. R. Mey, R. E. J. Berge, Guno H. K. Tjon, Taco J. Vries, Eric Ronken, François Hogenboom, George Warden, Arie H. Mulder, Anton N. M. Schoffelmeer, P. Bergen, J. A. Kleline, P. M. L. Janssen, J. G. M. Vaart, C. M. Kasbergen, D. H. G. Versteeg, D. J. Wildt, M. J. Velde, F. Engels, C. Berg, W. Vleeming, J. G. C. Amsterdam, J. Werner, L. Zee, A. Hertoe, E. Marcel Gelderen, Hendrik J. Agteresch, Emile L. E. Bruijne, J. P. Kats, L. M. A. Sassen, P. J. J. Admiraal, P. P. Verdouw, F. L. Muiswinkel, H. W. M. Steinhusch, B. Drukarch, J. C. Sloof, J. Vente, L. J. M. J. Vanderschuren, J. M. Ree, P. Verkade, A. J. Verkleij, W. H. Gispen, A. B. Oestreicher, R. J. Vermeulen, C. Goosen, E. Ch. Wolters, J. C. Stoof, V. A. M. Vincent, A. N. M. Schoffelmeer, H. W. M. Steinbush, F. Berlcenbosch, Hans-Peter Voss, David Donnell, J. P. M. Wesselman, E. VanBavel, J. A. E. Spaan, W. M. Zeilmaker, G. A. E. Klooster, G. J. M. J. Horbach, J. Zhang, J. S. Zhang, J. C. A. Meet

Publikováno v: Pharmacy World & Science. 15:I1-I15

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https://doi.org/10.1007/bf01875421

Phannacokinetic-pharmacodynamic modelling of the anticonvulsant effect of oxazepam in individual rats

Autor: M. W. E. Langemeijer, Meindert Danhof, R A Voskuyl, Ineke Postel-Westra, H. Meinardi, Douwe D. Breimer, J. Dingemanse

Publikováno v: British Journal of Pharmacology. 99:53-58

1. The purpose of this investigation was to examine in vivo drug-concentration anticonvulsant effect relationships of oxazepam in individual rats following administration of a single dose. 2. Whole blood concentration vs time profiles of oxazepam wer

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https://doi.org/10.1111/j.1476-5381.1990.tb14653.x

Pharmacodynamics of the anticonvulsant effect of oxazepam in aging BN/BiRij rats

Autor: Ineke Postel-Westra, Meindert Danhof, M. W. E. Langemeijer, A. Hoogerkamp, Annemiek M. Stijnen, Cornelis F.A. van Bezooijen, Rob A. Voskuyl

1. The purpose of this investigation was to examine the influence of increasing age on the pharmacokinetics and the time course of the anticonvulsant response of oxazepam in BN/BiRij rats as an animal model of aging. 2. Oxazepam was administered intr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9750eb427527a3f19b67381a1ec20ccc
https://europepmc.org/articles/PMC1907588/