Zobrazeno 1 - 10
of 24
pro vyhledávání: '"M. Vincent M. Lafleur"'
Autor:
Irene V. Bijnsdorp, Johannes van Rijn, Ben J. Slotman, Jaap van den Berg, Gitta K. Kuipers, Laurine E. Wedekind, M. Vincent M. Lafleur, Peter Sminia
Publikováno v:
Bijnsdorp, I, van den Berg, J, Kuipers, G, Wedekind, L, Slotman, B, van Rijn, J, Lafleur, M & Sminia, P 2007, ' Radiosensitizing potential of the selective cyclooygenase-2 (COX-2) inhibitor meloxicam on human glioma cells ', Journal of Neuro-Oncology, vol. 85, no. 1, pp. 25-31 .
Journal of Neuro-Oncology, 85(1), 25-31. Kluwer Academic Publishers
Bijnsdorp, I, Kuipers, G, Lafleur, M, Slotman, B, Sminia, P, van de Berg, J, van Rijn, J & Wedekind, L 2007, ' Radiosensitizing potential of the selective cyclooygenase-2 (COX-2) inhibitor meloxicam on human glioma cells ', Journal of Neuro-Oncology, vol. 85, no. 1, pp. 25-31 .
Bijnsdorp, I V, van den Berg, J, Kuipers, G K, Wedekind, L E, Slotman, B J, van Rijn, J, Lafleur, M V M & Sminia, P 2007, ' Radiosensitizing potential of the selective cyclooygenase-2 (COX-2) inhibitor meloxicam on human glioma cells ', Journal of Neuro-Oncology, vol. 85, no. 1, pp. 25-31 . https://doi.org/10.1007/s11060-007-9385-4
Journal of Neuro-Oncology, 85(1), 25-31. Kluwer Academic Publishers
Bijnsdorp, I, Kuipers, G, Lafleur, M, Slotman, B, Sminia, P, van de Berg, J, van Rijn, J & Wedekind, L 2007, ' Radiosensitizing potential of the selective cyclooygenase-2 (COX-2) inhibitor meloxicam on human glioma cells ', Journal of Neuro-Oncology, vol. 85, no. 1, pp. 25-31 .
Bijnsdorp, I V, van den Berg, J, Kuipers, G K, Wedekind, L E, Slotman, B J, van Rijn, J, Lafleur, M V M & Sminia, P 2007, ' Radiosensitizing potential of the selective cyclooygenase-2 (COX-2) inhibitor meloxicam on human glioma cells ', Journal of Neuro-Oncology, vol. 85, no. 1, pp. 25-31 . https://doi.org/10.1007/s11060-007-9385-4
The COX-2 protein is frequently overexpressed in human malignant gliomas. This expression has been associated with their aggressive growth characteristics and poor prognosis for patients. Targeting the COX-2 pathway might improve glioma therapy. In t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::016d464a2fd6ebe3130fa32e2cfb091a
https://doi.org/10.1007/s11060-007-9385-4
https://doi.org/10.1007/s11060-007-9385-4
Autor:
T. Rianne Stoter, M. Vincent M. Lafleur, Frank J. P. Hoebers, Ben J. Slotman, Michiel W. M. van den Brekel, R. Dubbelman, Marcel Verheij, Gitta K. Kuipers, Shuraila F. Zerp
Publikováno v:
Zerp, S F, Stoter, R, Hoebers, F J P, van den Brekel, M W M, Dubbelman, R, Kuipers, G K, Lafleur, M V M, Slotman, B J & Verheij, M 2015, ' Targeting anti-apoptotic Bcl-2 by AT-101 to increase radiation efficacy: data from in vitro and clinical pharmacokinetic studies in head and neck cancer ', Radiation Oncology, vol. 10, 158 . https://doi.org/10.1186/s13014-015-0474-9
Radiation Oncology, 10:158. BioMed Central Ltd
Radiation Oncology, 10:158. BioMed Central
Radiation Oncology (London, England)
Radiation Oncology, 10:158. BioMed Central Ltd
Radiation Oncology, 10:158. BioMed Central
Radiation Oncology (London, England)
BackgroundPro-survival Bcl-2 family members can promote cancer development and contribute to treatment resistance. Head and neck squamous cell carcinoma (HNSCC) is frequently characterized by overexpression of anti-apoptotic Bcl-2 family members. Inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35079d5ab02b4ba2c18d9338d97b8cee
https://doi.org/10.1186/s13014-015-0474-9
https://doi.org/10.1186/s13014-015-0474-9
Autor:
Lukas J.A. Stalpers, W. Peter Vandertop, Krista A. Van Nifterik, Ben J. Slotman, Peter Sminia, Sieger Leenstra, Rob J. van Andel, Paula H.M. Elkhuizen, Theo J. M. Hulsebos, M. Vincent M. Lafleur
Publikováno v:
van Nifterik, K A, Elkhuizen, P H M, van Andel, R J, Stalpers, L J A, Leenstra, S, Lafleur, M V M, Vandertop, W P, Slotman, B J, Hulsebos, T J M & Sminia, P 2006, ' Genetic profiling of a distant second glioblastoma multiforme after radiotherapy : Recurrence or second primary tumor? ', Journal of Neurosurgery, vol. 105, no. 5, pp. 739-44 . https://doi.org/10.3171/jns.2006.105.5.739
Journal of neurosurgery, 105(5), 739-744. American Association of Neurological Surgeons
Journal of Neurosurgery, 105(5), 739-44. American Association of Neurological Surgeons
Journal of Neurosurgery, 105(5), 739-744. American Association of Neurological Surgeons
Journal of neurosurgery, 105(5), 739-744. American Association of Neurological Surgeons
Journal of Neurosurgery, 105(5), 739-44. American Association of Neurological Surgeons
Journal of Neurosurgery, 105(5), 739-744. American Association of Neurological Surgeons
Object In nearly all patients with glioblastoma multiforme (GBM) a local recurrence develops within a short period of time. In this paper the authors describe two patients in whom a second GBM developed after a relatively long time interval at a site
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d826c165e68db5376f0bdd8a84be3a4
https://doi.org/10.3171/jns.2006.105.5.739
https://doi.org/10.3171/jns.2006.105.5.739
Autor:
C. René Leemans, Elisabeth Bloemena, Ben J. Slotman, T. Rianne Stoter, Isaäc van der Waal, Ernst J Smid, M. Vincent M. Lafleur, Johannes A. Langendijk
Publikováno v:
Smid, E J, Stoter, T R, Bloemena, E, Lafleur, M V M, Leemans, C R, van der Waal, I, Slotman, B J & Langendijk, J A 2006, ' The importance of immunohistochemical expression of EGFr in squamous cell carcinoma of the oral cavity treated with surgery and postoperative radiotherapy ', International Journal of Radiation-Oncology-Biology-Physics, vol. 65, pp. 1323-1329 . https://doi.org/10.1016/j.ijrobp.2006.03.011
International Journal of Radiation Oncology Biology Physics, 65, 1323-1329. Elsevier
International journal of radiation oncology, biology, physics, 65(5), 1323-9. Elsevier Inc.
International Journal of Radiation Oncology Biology Physics, 65(5), 1323-1329. ELSEVIER SCIENCE INC
Smid, E J, Stoter, T R, Bloemena, E, Lafleur, M V M, Leemans, C R, van der Waal, I, Slotman, B J & Langendijk, J A 2006, ' The importance of immunohistochemical expression of EGFr in squamous cell carcinoma of the oral cavity treated with surgery and postoperative radiotherapy ', International journal of radiation oncology, biology, physics, vol. 65, no. 5, pp. 1323-9 . https://doi.org/10.1016/j.ijrobp.2006.03.011
International Journal of Radiation-Oncology-Biology-Physics, 65, 1323-1329. Elsevier Science
International Journal of Radiation Oncology Biology Physics, 65, 1323-1329. Elsevier
International journal of radiation oncology, biology, physics, 65(5), 1323-9. Elsevier Inc.
International Journal of Radiation Oncology Biology Physics, 65(5), 1323-1329. ELSEVIER SCIENCE INC
Smid, E J, Stoter, T R, Bloemena, E, Lafleur, M V M, Leemans, C R, van der Waal, I, Slotman, B J & Langendijk, J A 2006, ' The importance of immunohistochemical expression of EGFr in squamous cell carcinoma of the oral cavity treated with surgery and postoperative radiotherapy ', International journal of radiation oncology, biology, physics, vol. 65, no. 5, pp. 1323-9 . https://doi.org/10.1016/j.ijrobp.2006.03.011
International Journal of Radiation-Oncology-Biology-Physics, 65, 1323-1329. Elsevier Science
Purpose: The aim of this study was to investigate the prognostic significance of epidermal growth factor (EGFr) expression in oral cavity squamous cell carcinoma (OCSCC) treated with curative surgery and postoperative radiotherapy.Methods and Materia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cc42527c0490c6307dad1f4bd055abe
https://doi.org/10.1016/j.ijrobp.2006.03.011
https://doi.org/10.1016/j.ijrobp.2006.03.011
Autor:
Peter Sminia, Paul van der Valk, W. Peter Vandertop, Thea M. Tadema, Paula H.M. Elkhuizen, M. Vincent M. Lafleur, Ben J. Slotman, T. Rianne Stoter, Gitta K. Kuipers
Publikováno v:
Journal of Cancer Research and Clinical Oncology, 131(10), 653-61. Springer Verlag
Journal of cancer research and clinical oncology, 131(10), 653-661. Springer Verlag
Sminia, P, Stoter, T R, van der Valk, P, Elkhuizen, P H M, Tadema, T M, Kuipers, G K, Vandertop, W P, Lafleur, M V M & Slotman, B J 2005, ' Expression of cyclooxygenase-2 and epidermal growth factor receptor in primary and recurrent glioblastoma multiforme ', Journal of Cancer Research and Clinical Oncology, vol. 131, no. 10, pp. 653-61 . https://doi.org/10.1007/s00432-005-0020-5
Journal of cancer research and clinical oncology, 131(10), 653-661. Springer Verlag
Sminia, P, Stoter, T R, van der Valk, P, Elkhuizen, P H M, Tadema, T M, Kuipers, G K, Vandertop, W P, Lafleur, M V M & Slotman, B J 2005, ' Expression of cyclooxygenase-2 and epidermal growth factor receptor in primary and recurrent glioblastoma multiforme ', Journal of Cancer Research and Clinical Oncology, vol. 131, no. 10, pp. 653-61 . https://doi.org/10.1007/s00432-005-0020-5
PURPOSE: To investigate the pattern and level of cyclooxygenase-2 (COX-2) expression in a series of high grade primary and recurrent glioblastoma multiforme (GBM) and correlation with time to recurrence and patients' survival following therapy. The r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5a3f3f4a9f94b98de8ce9592f46a60b
https://doi.org/10.1007/s00432-005-0020-5
https://doi.org/10.1007/s00432-005-0020-5
Autor:
Rob J. van Andel, Gitta K. Kuipers, M. Vincent M. Lafleur, Carola A. Reitsma-Wijker, Ben J. Slotman, Hester A. Poldervaart
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 568(2), 171-7. Elsevier
Kuipers, G K, Slotman, B J, Reitsma-Wijker, CA, Andel, R J, Poldervaart, H A & Lafleur, M V M 2004, ' Influence of anoxia on the induction of mutations by phenylalanine radicals during gamma-irradiation of plasmid DNA in aqueous solution. ', Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol. 568, no. 2, pp. 171-7 . https://doi.org/10.1016/j.mrfmmm.2004.08.005
Kuipers, G K, Slotman, B J, Reitsma-Wijker, CA, Andel, R J, Poldervaart, H A & Lafleur, M V M 2004, ' Influence of anoxia on the induction of mutations by phenylalanine radicals during gamma-irradiation of plasmid DNA in aqueous solution. ', Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol. 568, no. 2, pp. 171-7 . https://doi.org/10.1016/j.mrfmmm.2004.08.005
When DNA is irradiated in aqueous solution, most of the damage is inflicted by water-derived radicals. This is called the indirect effect of ionizing radiation. However in whole cells not only the primary formed water radicals play a role, because so
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aeeee74937e1e485e55a54feb40dc34
https://doi.org/10.1016/j.mrfmmm.2004.08.005
https://doi.org/10.1016/j.mrfmmm.2004.08.005
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 479:95-99
Because damage to the cellular DNA is very hazardous for a cell, it is important to identify compounds, which can cause DNA damage. To investigate the mutagenic effect of a particular agent of interest, usually mutation spectra are determined in a se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f372bb4348848c360d25516fff56e8a
https://doi.org/10.1016/s0027-5107(01)00155-5
https://doi.org/10.1016/s0027-5107(01)00155-5
Autor:
Gitta K. Kuipers, Hester A Poldervaart, M. Vincent M. Lafleur, Ben J. Slotman, Carola A Reitsma-Wijker
Publikováno v:
Mutation Research/DNA Repair. 461:189-195
One of the most predominating oxidative DNA damages, both spontaneously formed and after gamma-radiation is 7, 8-dihydro-8-oxoguanine (8oxoG). This 8oxoG is a mutagenic lesion because it can mispair with adenine instead of the correct cytosine leadin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1341c4a2b7f935f1123b94eb1885e96a
https://doi.org/10.1016/s0921-8777(00)00050-1
https://doi.org/10.1016/s0921-8777(00)00050-1
Autor:
Gitta K. Kuipers, Hester A Poldervaart, Ben J. Slotman, Carola A Reitsma-Wijker, Ingrid M.J van Vilsteren, M. Vincent M. Lafleur
Publikováno v:
Mutation Research/DNA Repair. 460:117-125
Base excision repair (BER) is a very important repair mechanism to remove oxidative DNA damage. A major oxidative DNA damage after exposure to ionizing radiation is 7,8-dihydro-8-oxoguanine (8oxoG). 8oxoG is a strong mutagenic lesion, which may cause
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4297caa729a7c7f57f66e44cb179dac
https://doi.org/10.1016/s0921-8777(00)00021-5
https://doi.org/10.1016/s0921-8777(00)00021-5
Publikováno v:
Carcinogenesis, 17(1), 5-11. Oxford University Press
Gille, J J P, Wientjes, N M, Lafleur, M V M, Joenje, H & Retèl, J 1996, ' Biological consequences of DNA damage introduced in bacteriophage PM2 DNA by hydrogen peroxide-mediated free radical reactions ', Carcinogenesis, vol. 17, no. 1, pp. 5-11 . https://doi.org/10.1093/carcin/17.1.5
Gille, J J P, Wientjes, N M, Lafleur, M V M, Joenje, H & Retèl, J 1996, ' Biological consequences of DNA damage introduced in bacteriophage PM2 DNA by hydrogen peroxide-mediated free radical reactions ', Carcinogenesis, vol. 17, no. 1, pp. 5-11 . https://doi.org/10.1093/carcin/17.1.5
In order to study the biological consequences of DNA damage induced by H2O2-mediated free radical reactions, DNA from bacteriophage PM2 was exposed to H2O2, Fe3+-citrate and ascorbate either alone or in combination. Induction of DNA lesions was deter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0def508ef920168ccdc264489e05297e
https://doi.org/10.1093/carcin/17.1.5
https://doi.org/10.1093/carcin/17.1.5