Zobrazeno 1 - 10
of 605
pro vyhledávání: '"M. Verfaillie"'
Autor:
Jonathan Sai‐Hong Chui, Teresa Izuel‐Idoype, Alessandra Qualizza, Rita Pires deAlmeida, Lindsey Piessens, Bernard K. van derVeer, Gert Vanmarcke, Aneta Malesa, Paraskevi Athanasouli, Ruben Boon, Joris Vriens, Leo vanGrunsven, Kian Peng Koh, Catherine M. Verfaillie, Frederic Lluis
Publikováno v:
Advanced Science, Vol 11, Iss 7, Pp n/a-n/a (2024)
Abstract Terminally differentiated cells are commonly regarded as the most stable cell state in adult organisms, characterized by growth arrest while fulfilling their specialized functions. A better understanding of the mechanisms involved in promoti
Externí odkaz:
https://doaj.org/article/d3f33e15b1534ffcbb0747b487db0584
Autor:
Irene Mariam Roy, P.V. Anu, Samantha Zaunz, Srinu Reddi, Aravind M. Giri, Rithika Saroj Sankar, Sarah Schouteden, Joerg Huelsken, Catherine M. Verfaillie, Satish Khurana
Publikováno v:
iScience, Vol 25, Iss 10, Pp 105171- (2022)
Summary: Interaction with microenvironmental factors is crucial for the regulation of hematopoietic stem cell (HSC) function. Stroma derived factor (SDF)-1α supports HSCs in the quiescent state and is central to the homing of transplanted HSCs. Here
Externí odkaz:
https://doaj.org/article/9fab39df289c4702bddebe5f05788178
Autor:
Leonora Szabo, Amandine Grimm, Juan Antonio García-León, Catherine M. Verfaillie, Anne Eckert
Publikováno v:
Cells, Vol 12, Iss 10, p 1385 (2023)
Pathological abnormalities in the tau protein give rise to a variety of neurodegenerative diseases, conjointly termed tauopathies. Several tau mutations have been identified in the tau-encoding gene MAPT, affecting either the physical properties of t
Externí odkaz:
https://doaj.org/article/004d3cbf0ae74b2da4b7b4953f1b76f3
Autor:
Jonathan De Smedt, Elise Anne van Os, Irene Talon, Sreya Ghosh, Burak Toprakhisar, Rodrigo Furtado Madeiro Da Costa, Samantha Zaunz, Marta Aguirre Vazquez, Ruben Boon, Pieter Baatsen, Ayla Smout, Stefaan Verhulst, Leo A. van Grunsven, Catherine M. Verfaillie
Publikováno v:
Cell Death and Disease, Vol 12, Iss 1, Pp 1-18 (2021)
Abstract To date, there is no representative in vitro model for liver sinusoidal endothelial cells (LSECs), as primary LSECs dedifferentiate very fast in culture and no combination of cytokines or growth factors can induce an LSEC fate in (pluripoten
Externí odkaz:
https://doaj.org/article/a72ccbfa4b2f428e822457e0c7616dda
Autor:
Ruben Boon, Manoj Kumar, Tine Tricot, Ilaria Elia, Laura Ordovas, Frank Jacobs, Jennifer One, Jonathan De Smedt, Guy Eelen, Matthew Bird, Philip Roelandt, Ginevra Doglioni, Kim Vriens, Matteo Rossi, Marta Aguirre Vazquez, Thomas Vanwelden, François Chesnais, Adil El Taghdouini, Mustapha Najimi, Etienne Sokal, David Cassiman, Jan Snoeys, Mario Monshouwer, Wei-Shou Hu, Christian Lange, Peter Carmeliet, Sarah-Maria Fendt, Catherine M. Verfaillie
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Hepatocytes grown in a dish are immature and do not metabolize compounds as a real liver would. Here, the authors supply stem cell-derived hepatocytes with amino acids at a higher concentration than nutritionally necessary, changing the metabolism of
Externí odkaz:
https://doaj.org/article/0a789642bd074590a245141b427513bf
Publikováno v:
Cells, Vol 12, Iss 2, p 301 (2023)
Liver transplantation is currently the only curative therapy for patients with acute or chronic liver failure. However, a dramatic gap between the number of available liver grafts and the number of patients on the transplantation waiting list emphasi
Externí odkaz:
https://doaj.org/article/f5a230d7a2154c35b38c1f53a98cdc90
Autor:
Marion Mesnieres, Anna-Marei Böhm, Nicolas Peredo, Dana Trompet, Roger Valle-Tenney, Manmohan Bajaj, Nikky Corthout, Elena Nefyodova, Ruben Cardoen, Pieter Baatsen, Sebastian Munck, Andras Nagy, Jody J. Haigh, Satish Khurana, Catherine M. Verfaillie, Christa Maes
Publikováno v:
Cell Reports, Vol 36, Iss 8, Pp 109618- (2021)
Summary: Hematopoietic stem and progenitor cell (HSPC) engraftment after transplantation during anticancer treatment depends on support from the recipient bone marrow (BM) microenvironment. Here, by studying physiological homing of fetal HSPCs, we sh
Externí odkaz:
https://doaj.org/article/8bace80af3a741fb98e120995c848c91
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
Frontotemporal dementia (FTD) is a neurodegenerative disease, leading to behavioral changes and language difficulties. Heterozygous loss-of-function mutations in progranulin (GRN) induce haploinsufficiency of the protein and are associated with up to
Externí odkaz:
https://doaj.org/article/5c99debbd58a4f338d0756a975e5bd57
Autor:
Walter C Low, Catherine M Verfaillie
Stem cells have the ability to differentiate into cells that are found throughout the body. This fundamental property of stem cells suggests that they can potentially be used to replace degenerative cells within the body, and regenerate the functiona
Autor:
Kim Vanuytsel, Qing Cai, Satish Khurana, Swati Shetty, Joris R. Vermeesch, Laura Ordovas, Catherine M. Verfaillie
Publikováno v:
Stem Cell Research, Vol 44, Iss , Pp - (2020)
Externí odkaz:
https://doaj.org/article/0296abf410e34c1c8c776f48ee19d332