Modelling Senescence In Osteoarthritis: Combining Irradiation And Mechanical Loading In Human Osteochondral Explants

Autor: I. Boone, J.J. van den Berg, M. Varela Eirin, M. Tuerlings, E. Houtman, M. Demaria, I. Meulenbelt

Publikováno v: Osteoarthritis and Cartilage. 31:S333-S334

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fe428a385084ce07b1bca5df3fd70542
https://doi.org/10.1016/j.joca.2023.01.367

Senolytic Activity of Small Molecular Polyphenols from Olive Restores Chondrocyte Redifferentiation and Promotes a Pro-Regenerative Environment in Osteoarthritis

Autor: Alfonso Blanco, Antonio Casado-Díaz, Paula Carpintero-Fernández, Agustín Sánchez-Temprano, Mustapha Kandouz, M. Varela-Eirin, Maria D. Mayan, Adrian Varela-Vazquez, Alfonso Calañas Continente, Eduardo Fonseca, José R. Caeiro, Carlos L. Paíno, Virginia Mato

Publikováno v: RUC. Repositorio da Universidade da Coruña
instname
RUC: Repositorio da Universidade da Coruña
Universidade da Coruña (UDC)
Aging (Albany NY)

[Abstract] Articular cartilage and synovial tissue from patients with osteoarthritis (OA) show an overactivity of connexin43 (Cx43) and accumulation of senescent cells associated with disrupted tissue regeneration and disease progression. The aim of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c694dce7fb94080b515bb644f4a791ab
https://hdl.handle.net/2183/26271

Cartilage regeneration and ageing: Targeting cellular plasticity in osteoarthritis

Autor: Jesus Loureiro, Maria D. Mayan, Eduardo Fonseca, M. Varela-Eirin, Manuel Collado, Silvia Corrochano, José R. Caeiro

Publikováno v: Ageing Research Reviews. 42:56-71

Ageing processes play a major contributing role for the development of Osteoarthritis (OA). This prototypic degenerative condition of ageing is the most common form of arthritis and is accompanied by a general decline, chronic pain and mobility defic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eeaa314599f4d4f3f8f9382abe369ef
https://doi.org/10.1016/j.arr.2017.12.006

Senolytic activity of small molecular polyphenols from olive restores chondrocyte redifferentiation and cartilage regeneration in osteoarthritis

Autor: Adrian Varela-Vazquez, Antonio Casado-Díaz, Alfonso Blanco, Carlos L. Paíno, Alfonso Calanas-Continente, Maria D. Mayan, M. Varela-Eirin, Mustapha Kandouz, Eduardo Fonseca, Virginia Mato, José R. Caeiro

Osteoarthritis (OA) is the most prevalent disorder of articulating joints and a leading cause of disability in humans, affecting half of the world’s population aged 65 years or older. Articular cartilage and synovial tissue from OA patients show an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfecf45eb7a12d30df5b1dfdf3de0e42

The C-terminal domain of connexin43 modulates cartilage structure via chondrocyte phenotypic changes

Autor: Benigno Acea, John F. Bechberger, Eduardo Fonseca, Adrian Varela-Vazquez, Maria D. Mayan, M. Varela-Eirin, Raquel Gago-Fuentes, Christian C. Naus

Publikováno v: Oncotarget

Chondrocytes in cartilage and bone cells population express connexin43 (Cx43) and gap junction intercellular communication (GJIC) is essential to synchronize cells for coordinated electrical, mechanical, metabolic and chemical communication in both t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8757a5b144c4aeda8a2211d1e485bce5
http://europepmc.org/articles/PMC5341963