Radioimmunotherapy of human head and neck squamous cell carcinoma xenografts with 131I-labelled monoclonal antibody E48 IgG

Autor: B. J. M. Braakhuis, M. Gerretsen, Ad H. G. J. Schrijvers, C. J. L. M. Meijer, M. van Walsum, G. B. Snow, G.A.M.S. (Guus) van Dongen, Jasper J. Quak

Publikováno v: Gerretsen, M, Schrijvers, A H G J, Van Walsum, M, Braakhuis, B J M, Quak, J J, Meijer, C, Snow, G B & Van Dongen, G A M S 1992, ' Radioimmunotherapy of human head and neck squamous cell carcinoma xenografts with 131 i-labelled monoclonal antibody e48 igg ', British Journal of Cancer, vol. 66, no. 3, pp. 496-502 . https://doi.org/10.1038/bjc.1992.302
British Journal of Cancer
British Journal of Cancer, 66(3), 496-502. Nature Publishing Group

Monoclonal antibody (MAb) E48 reacts with a 22 kD antigen exclusively expressed in squamous and transitional epithelia and their neoplastic counterparts. Radiolabelled with99mTc, MAb E48 is capable of targeting metastatic and recurrent disease in pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9f41dccb9ed0b148bb63acbcc5d9daa
https://doi.org/10.1038/bjc.1992.302

Superior localisation and imaging of radiolabelled monoclonal antibody E48 F(ab')2 fragment in xenografts of human squamous cell carcinoma of the head and neck and of the vulva as compared to monoclonal antibody E48 IgG

Autor: M. Gerretsen, Jasper J. Quak, C. J. L. M. Meijer, J. S. Suh, G.A.M.S. (Guus) van Dongen, G. B. Snow, M. Van Walsum

Publikováno v: British Journal of Cancer
British Journal of Cancer, 63(1), 37-44. Nature Publishing Group
Gerretsen, M, Quak, J J, Suh, J S, Van Walsum, M, Meijer, C J L M, Snow, G B & Van Dongen, G A M S 1991, ' Superior localisation and imaging of radiolabelled monoclonal antibody e48 f(ab') 2 fragment in xenografts of human squamous cell carcinoma of the head and neck and of the vulva as compared to monoclonal antibody e48 igg ', British Journal of Cancer, vol. 63, no. 1, pp. 37-44 . https://doi.org/10.1038/bjc.1991.9

Monoclonal antibody (MAb) E48 and its F(ab')2 fragment, radiolabelled with1311, were tested for tumour localisation and imaging in nude mice bearing a squamous cell carcinoma xenograft line derived from a head and neck carcinoma (HNX-HN) or from a vu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc24eab894f3cb8c0b18d2137c3fbe6c
http://europepmc.org/articles/PMC1971635

186Re-labeled monoclonal antibody E48 immunoglobulin G-mediated therapy of human head and neck squamous cell carcinoma xenografts

Autor: M, Gerretsen, G W, Visser, M, van Walsum, C J, Meijer, G B, Snow, G A, van Dongen

Publikováno v: Cancer research. 53(15)

In our laboratory, a solid-phase synthesis of 186Re-mercaptoacetyltriglycine for reproducible and aseptic production of stable 186Re-monoclonal antibody conjugates was recently developed. Monoclonal antibody (MAb) E48 IgG, when labeled with 99mTc acc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::013742b7ec1e6ba148703aad07a90512
https://pubmed.ncbi.nlm.nih.gov/8339258

Enhanced therapeutic efficacy of 5'deoxy-5-fluorouridine in 5-fluorouracil resistant head and neck tumours in relation to 5-fluorouracil metabolising enzymes

Autor: H.M. Pinedo, G.J. Peters, Boudewijn J.M. Braakhuis, E.J. Laurensse, E. A. De Bruijn, M. Van Walsum

Publikováno v: British Journal of Cancer

Four human head and neck xenograft (HNX) tumour lines grown in nude mice and two murine colon carcinomas (Colon 26 and 38) were tested for their sensitivity to 5-fluorouracil (5-FU) and its prodrug 5'deoxy-5-fluorouridine (Doxifluridine, 5'd-FUR). 5-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13bc4d9691a0c5210344ae2ad1dc4bd9
http://europepmc.org/articles/PMC2247094

Preclinical antitumor activity of 5-aza-2'-deoxycytidine against human and neck cancer xenografts [corrected]

Autor: B J, Braakhuis, G A, van Dongen, M, van Walsum, A, Leyva, G B, Snow

Publikováno v: Investigational new drugs. 6(4)

The antitumor activity of 5-aza-2'-deoxycytidine (5-aza-dCyd), a nucleoside analog, was established in human head and neck cancer xenografts, transplanted in nude mice. A significant response was noted in 3 of 5 lines, when the drug was injected intr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9e150bebb49f3798b18207ca6654f999
https://pubmed.ncbi.nlm.nih.gov/2466014