Dantrolene is neuroprotective in vitro, but does not affect survival in SOD1(G⁹³A) mice

Autor: K A, Staats, M, Van Rillaer, W, Scheveneels, R, Verbesselt, P, Van Damme, W, Robberecht, L, Van Den Bosch

Publikováno v: Neuroscience. 220

Amyotrophic Lateral Sclerosis (ALS) is a devastating progressive neurodegenerative disease. One of the proposed disease mechanisms is excitotoxicity, in which excessive cytosolic calcium causes neuronal death. Although most calcium may originate from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a7546250339d67f5e8464ee98df20892
https://pubmed.ncbi.nlm.nih.gov/22750242

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Beta-2 microglobulin is important for disease progression in a murine model for amyotrophic lateral sclerosis.

Autor: Staats KA; KU Leuven Laboratory of Neurobiology and Leuven Research Institute for Neuroscience and Disease (LIND) Leuven, Belgium ; VIB Vesalius Research Center, KU Leuven Leuven, Belgium ; VIB Autoimmune Genetics Laboratory, KU Leuven Leuven, Belgium ; Department of Microbiology and Immunology, University of Leuven Leuven, Belgium., Schönefeldt S; VIB Autoimmune Genetics Laboratory, KU Leuven Leuven, Belgium ; Department of Microbiology and Immunology, University of Leuven Leuven, Belgium., Van Rillaer M; VIB Autoimmune Genetics Laboratory, KU Leuven Leuven, Belgium ; Department of Microbiology and Immunology, University of Leuven Leuven, Belgium., Van Hoecke A; KU Leuven Laboratory of Neurobiology and Leuven Research Institute for Neuroscience and Disease (LIND) Leuven, Belgium ; VIB Vesalius Research Center, KU Leuven Leuven, Belgium., Van Damme P; KU Leuven Laboratory of Neurobiology and Leuven Research Institute for Neuroscience and Disease (LIND) Leuven, Belgium ; VIB Vesalius Research Center, KU Leuven Leuven, Belgium ; Neurology, University Hospitals Leuven Leuven, Belgium., Robberecht W; KU Leuven Laboratory of Neurobiology and Leuven Research Institute for Neuroscience and Disease (LIND) Leuven, Belgium ; VIB Vesalius Research Center, KU Leuven Leuven, Belgium ; Neurology, University Hospitals Leuven Leuven, Belgium., Liston A; VIB Autoimmune Genetics Laboratory, KU Leuven Leuven, Belgium ; Department of Microbiology and Immunology, University of Leuven Leuven, Belgium., Van Den Bosch L; KU Leuven Laboratory of Neurobiology and Leuven Research Institute for Neuroscience and Disease (LIND) Leuven, Belgium ; VIB Vesalius Research Center, KU Leuven Leuven, Belgium.

Publikováno v: Frontiers in cellular neuroscience [Front Cell Neurosci] 2013 Dec 10; Vol. 7, pp. 249. Date of Electronic Publication: 2013 Dec 10 (Print Publication: 2013).