Frusemide and its acyl glucuronide show a short and long phase in elimination kinetics and pharmacodynamic effect in man

Autor: M. van den Biggelaar-Martea, Tom B. Vree, C.P.W.G.M. Verwey-van Wissen

Publikováno v: Journal of Pharmacy and Pharmacology, 47, 964-969
Journal of Pharmacy and Pharmacology, 47, pp. 964-969
Journal of Pharmacy and Pharmacology, 47, 11, pp. 964-969

The pharmacokinetics of 80 mg frusemide given orally were investigated in normal subjects using a direct HPLC method for parent drug and its acyl glucuronide conjugate. Two half-lives could be distinguished in the plasma elimination of both frusemide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d450ffd0c3847cfc433d94478d1a11de
https://hdl.handle.net/2066/22072

Probenecid inhibits the glucuronidation of indomethacin andO-desmethylindomethacin in humans

Autor: C.P.W.G.M. Verwey-van Wissen, M. van den Biggelaar-Martea, E.W.J. van Ewijk-Beneken Kolmer, Tom B. Vree

Publikováno v: Pharmacy World & Science. 16:22-26

Indomethacin is metabolized in humans by O-demethylation, and by acyl glucuronidation to the 1-O-glucuronide. Indomethacin, its metabolite, and their conjugates can be measured directly by gradient high-pressure liquid chromatographic analysis withou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d590e4fa2ea1dd30352ba4599121a41
https://doi.org/10.1007/bf01870935

Determination of indomethacin, its metabolites and their glucuronides in human plasma and urine by means of direct gradient high-performance liquid chromatographic analysis

Autor: Tom B. Vree, C.P.W.G.M. Verwey-van Wissen, M. van den Biggelaar-Martea

Publikováno v: Journal of Chromatography B: Biomedical Sciences and Applications. 616:271-282

Indomethacin is metabolized in humans by O-demethylation, and by acyl glucuronidation to the 1-O-glucuronide. Indomethacin, its metabolite O-desmethylindomethacin (DMI) and their conjugates can be measured directly by gradient high-performance liquid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::281940a791149efb394bccb4e8d66f33
https://doi.org/10.1016/0378-4347(93)80395-k

Direct gradient reversed-phase HPLC analysis and preliminary pharmacokinetics of nalidixic acid, 7-hydroxymethylnalidixic acid, 7-carboxynalidixic acid, and their corresponding glucuronide conjugates in humans

Autor: Yechiel A. Hekster, E.W.J. van Ewijk-Beneken Kolmer, Tom B. Vree, M. van den Biggelaar-Martea

Publikováno v: Pharmacy World & Science. 15:98-104

A gradient reversed-phase high pressure liquid chromatographic analysis was developed for the direct measurement of nalidixic acid with its acyl glucuronide, 7-hydroxymethylnalidixic acid with its acyl and ether glucuronides, and 7-carboxynalidixic a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6ea8d8333150157795dbc74363f30c8
https://doi.org/10.1007/bf02113937

High performance liquid chromatography and preliminary pharmacokinetics of rufloxacin and its metabolites N-desmethylrufloxacin and rufloxacinsulfoxide in plasma and urine of humans

Autor: B. P. Imbimbo, M. van den Biggelaar-Martea, Tom B. Vree

Publikováno v: European Journal of Drug Metabolism and Pharmacokinetics. 17:45-49

An HPLC analysis was developed for the measurement of rufloxacin and two of its possible metabolites N-desmethylrufloxacin and rufloxacinsulfoxide. Humans are unable to form these two metabolites, while no other metabolites could be detected in the H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::393c2bd9c6250db852fbc6fe213b4372
https://doi.org/10.1007/bf03189987