Zobrazeno 1 - 10 of 11 pro vyhledávání: '"M. V. Vasantha Kumar"'
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Akademický článek
Phosphorylation induced cochaperone unfolding promotes kinase recruitment and client class-specific Hsp90 phosphorylation
Autor: Ashleigh B. Bachman, Dimitra Keramisanou, Wanping Xu, Kristin Beebe, Michael A. Moses, M. V. Vasantha Kumar, Geoffrey Gray, Radwan Ebna Noor, Arjan van der Vaart, Len Neckers, Ioannis Gelis
Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
The Hsp90 chaperone cycle is influenced by multiple phosphorylation events but their regulatory functions are poorly understood. Here, the authors show that phosphorylation and unfolding of cochaperone Cdc37 tailors the Hsp90 chaperone cycle by recru
Externí odkaz: https://doaj.org/article/1ad30120ac2049d29abb8f3ab36b01ec
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2
Mechanism of proton transfer in class A β-lactamase catalysis and inhibition by avibactam
Autor: M V Vasantha Kumar, Radwan Ebna Noor, Ioannis Gelis, Ruslan Sanishvili, Orville A. Pemberton, H. Lee Woodcock, M. Trent Kemp, Yu Chen, Fiona L. Kearns
Publikováno v: Proc Natl Acad Sci U S A
Gram-negative bacteria expressing class A β-lactamases pose a serious health threat due to their ability to inactivate all β-lactam antibiotics. The acyl–enzyme intermediate is a central milestone in the hydrolysis reaction catalyzed by these enz
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e35085197c6cad4aad3c2974c2f7b9d
https://doi.org/10.1073/pnas.1922203117
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3
1H, 13C, and 15N chemical shift assignments of a G-quadruplex forming sequence within the KRAS proto-oncogene promoter region
Autor: Gilmar F. Salgado, M V Vasantha Kumar, Jean-Louis Mergny, Julien Marquevielle
Publikováno v: Biomolecular NMR Assignments
Single stranded guanine rich DNA (or RNA) sequences adopt noncanonical secondary structures called G-quadruplexes (G4). Functionally, quadruplexes control gene transcription and regulate activities such as replication, gene recombination or alternati
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78779c2563728702371a83342a1162ea
https://doi.org/10.1007/s12104-017-9793-0
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4
J. Am. Chem. Soc
Autor: Gilmar F. Salgado, Frédéric Rosu, M V Vasantha Kumar, Jean-Louis Mergny, Caterina Lombardo, Céline Douat, Gilles Guichard
Publikováno v: Journal of the American Chemical Society
Journal of the American Chemical Society, American Chemical Society, 2019, 141 (6), pp.2516-2525
Journal of the American Chemical Society, American Chemical Society, 2019, 141 (6), pp.2516-2525. ⟨10.1021/jacs.8b12240⟩
International audience; A number of foldamer backbones have been described as useful mimics of protein secondary structure elements, enabling for example the design of synthetic oligomers with the ability to engage specific protein surfaces. Syntheti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d257a85857deeafc38630d6faed273ef
https://hal.archives-ouvertes.fr/hal-03181429
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5
Phosphorylation induced cochaperone unfolding promotes kinase recruitment and client class-specific Hsp90 phosphorylation
Autor: Ashleigh Bachman, Geoffrey M. Gray, Ioannis Gelis, Michael A. Moses, Radwan Ebna Noor, Dimitra Keramisanou, Len Neckers, Kristin Beebe, M V Vasantha Kumar, Arjan van der Vaart, Wanping Xu
Publikováno v: Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
During the Hsp90-mediated chaperoning of protein kinases, the core components of the machinery, Hsp90 and the cochaperone Cdc37, recycle between different phosphorylation states that regulate progression of the chaperone cycle. We show that Cdc37 pho
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14b3d7bfeac843adb567f032eb2d2f2b
https://pubmed.ncbi.nlm.nih.gov/29343704
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6
High-Resolution Characterization of Intrinsic Disorder in Proteins: Expanding the Suite of 13C-Detected NMR Spectroscopy Experiments to Determine Key Observables
Autor: Roberta Pierattelli, Leonardo Gonnelli, Isabella C. Felli, Ivano Bertini, M V Vasantha Kumar
Publikováno v: ChemBioChem. 12:2347-2352
Order in disorder: The characterization of intrinsically disordered proteins by NMR spectroscopy is a necessity on the one hand and a continuous challenge on the other. We propose two experiments that provide diagnostic parameters to monitor the degr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d80fc3c9481b30ac89f1ccfe2a97898
https://doi.org/10.1002/cbic.201100406
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8
Improving the chemical shift dispersion of multidimensional NMR spectra of intrinsically disordered proteins
Autor: Wolfgang Bermel, Soraya Serrano, Isabella C. Felli, Marta Bruix, Roberta Pierattelli, M V Vasantha Kumar
Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Intrinsically disordered proteins (IDPs) have recently attracted the attention of the scientific community challenging the well accepted structure–function paradigm. In the characterization of the dynamic features of proteins nuclear magnetic reson
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::846d7e6c754a696078033287ba2437bd
https://pubmed.ncbi.nlm.nih.gov/23314728
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9
Exclusively heteronuclear (13) C-detected amino-acid-selective NMR experiments for the study of intrinsically disordered proteins (IDPs)
Autor: Noam Y. Haba, Roberta Pierattelli, Wolfgang Bermel, Isabella C. Felli, Ivano Bertini, M V Vasantha Kumar, Jordan H. Chill
Publikováno v: Chembiochem : a European journal of chemical biology. 13(16)
Carbon-13 direct-detection NMR methods have proved to be very useful for the characterization of intrinsically disordered proteins (IDPs). Here we present a suite of experiments in which amino-acid-selective editing blocks are encoded in CACON- and C
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::154fbbca68a2f85d378ba270f839d0fd
https://pubmed.ncbi.nlm.nih.gov/23060071
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10
N-H...F hydrogen bonds in fluorinated benzanilides: NMR and DFT study
Autor: G. N. Manjunatha Reddy, M V Vasantha Kumar, T. N. Guru Row, N. Suryaprakash
Publikováno v: Physical chemistry chemical physics : PCCP. 12(40)
Using (19)F and (1)H-NMR (with (14)N decoupling) spectroscopic techniques together with density functional theoretical (DFT) calculations, we have investigated weak molecular interactions in isomeric fluorinated benzanilides. Simultaneous presence of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e157c2febbcaecec3c356c6b1cea2590
https://pubmed.ncbi.nlm.nih.gov/20820573
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