Zobrazeno 1 - 10
of 14
pro vyhledávání: '"M. V. Miroshnikov"'
Publikováno v:
Translational Medicine. 9:44-77
Cytochrome P450 enzymes play a key role in drug biotransformation. The expression and activity of each CYP450 is influenced by a unique combination of biochemical factors, species and genetic differences, age, sex, nutrition and etc.Cytochromes P450
Autor:
Maxim A. Kochergin, Alexander A. Spasov, D. V. Mal’tsev, D. S. Yakovlev, Maria O. Skripka, Lyudmila N. Divaeva, K. T. Sultanova, M. V. Miroshnikov
Publikováno v:
Research Results in Pharmacology 7(2): 31-37
Research Results in Pharmacology, Vol 7, Iss 2, Pp 31-37 (2021)
Research Results in Pharmacology, Vol 7, Iss 2, Pp 31-37 (2021)
Introduction: Searching for new compounds with anti-anxiety activity resulting from the combination of privileged scaffolds is a promising direction in medicinal chemistry and in the development of new drugs. Anxiolytic potential and cytotoxic proper
Publikováno v:
Russian Journal of Bioorganic Chemistry. 47:622-652
This article presents a review of studies of new pharmacological substances in the aspect of their anxiolytic activity. These substances are derivatives of various chemical classes. The variety of synthesized substances described in this article is a
Autor:
D. V. Maltsev, A. A Spasov, M. V. Miroshnikov, M. O. Skripka, Yu. Yu Dementenko, E. M Chernikova
Publikováno v:
Journal of Volgograd State Medical University. 18:131-136
For the substance under the code DAB-21, a pronounced neuropsychotropic potential was previously shown. In this study, possible directions of the influence of the studied substance on basic mediator systems of the CNS are considered. According to the
Publikováno v:
Research Results in Pharmacology, Vol 6, Iss 3, Pp 9-14 (2020)
Research Results in Pharmacology 6(3): 9-14
Research Results in Pharmacology 6(3): 9-14
Introduction: Diazepino[1,2-a]benzimidazole derivatives showed anxiolytic (EPM, L/D box, Vogel test), antidepressant (Tail Suspension test, Porsolt test), anticonvulsant (Pentylenetetrazole-Induced seizures) and analgesic (Tail-Flick, Hot Plate) acti
Autor:
Alexander A. Spasov, S. K. Kotovskaya, Vladimir L. Rusinov, V. A. Kosolapov, K. T. Sultanova, M. V. Miroshnikov, Irina M. Sapozhnikova, D. V. Mal’tsev
Publikováno v:
Toxicological Review. :39-43
The article presents the results of a study of the neurotoxicological profile of the new compound AB-19, acting on collagen glycation end products (AGE) and their receptors (RAGE), for the prevention and treatment of diabetes complications. The multi
Autor:
Alexander A. Spasov, D. V. Mal’tsev, Anatolii S. Morkovnik, O. N. Zhukovskaya, K. T. Sultanova, M. V. Miroshnikov, Maria O. Skripka
Publikováno v:
Russian Journal of Bioorganic Chemistry. 46:107-114
This paper presents a study of the anxiolytic activity of compounds that belong to two classes of chemical groups: derivatives of 11H-2,3,4,5-tetrahydro[1,3]diazepino[1,2-a]benzimidazole (BIF) and derivatives of 2-mercaptobenzimidazole (AZH). The stu
Autor:
Anatolii S. Morkovnik, D. V. Mal’tsev, Lyudmila N. Divaeva, Pavel M. Vassiliev, Alexander A. Spasov, Nataliya V Eliseeva, Tat’yana A. Kuz’menko, Maria O. Skripka, A. N. Kochetkov, M. V. Miroshnikov, Yuliya V. Lifanova
Publikováno v:
Molecules, Vol 26, Iss 6049, p 6049 (2021)
Molecules
Volume 26
Issue 19
Molecules
Volume 26
Issue 19
A number of novel 2,3,4,5-tetrahydro[1,3]diazepino[1,2-a]benzimidazole derivatives 2 were obtained by alkylation mainly in the 1H-tautomeric form of 2,3,4,5-tetrahydro[1,3]diazepino[1,2-a]benzimidazole or its 8,9-dimethyl-substituted analog 4-chlorob
Autor:
Alexander A. Spasov, Pavel M. Vassiliev, Darya Merezhkina, V. A. Kosolapov, Viktor Sirotenko, R. A. Litvinov, M. V. Miroshnikov, Alexander Ozerov, Denis A. Babkov, N. A. Gurova, Alena Taran, Vladlen G. Klochkov, A. V. Borisov, Natalia Ovsyankina
The Na+/H+ exchanger isoform 1 (NHE-1) attracts ongoing attention as a validated drug target for the management of cardiovascular and ocular diseases owing to cytoprotective, anti-ischemic and anti-inflammatory properties of NHE-1 inhibitors. Herein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f18189481f81b5cbd4810acae79acaa6
https://doi.org/10.21203/rs.3.rs-877643/v1
https://doi.org/10.21203/rs.3.rs-877643/v1
Autor:
K. A. Gajdukova, V.S. Sirotenko, D.V. Mal'cev, A.F. Kucherjavenko, Alexander A. Spasov, K. T. Sultanova, M. V. Miroshnikov, Maria O. Skripka
Publikováno v:
Journal of Volgograd State Medical University. 71:116-119