Zobrazeno 1 - 10
of 28
pro vyhledávání: '"M. V. Miroshnikov"'
Publikováno v:
Регуляторные исследования и экспертиза лекарственных средств, Vol 14, Iss 4, Pp 448-462 (2024)
INTRODUCTION. The determination of nephrotoxicity markers is a useful and necessary step in the detection of renal injury in animal experiments; these markers help accurately localise organ damage. With multiple damaging agents, known nephrotoxicity
Externí odkaz:
https://doaj.org/article/53d85317f6654e4db4c4d6e44419c5c7
Publikováno v:
Регуляторные исследования и экспертиза лекарственных средств, Vol 14, Iss 3, Pp 283-294 (2024)
INTRODUCTION. Functional examination of the urinary system, and particularly the kidneys, is an important challenge in preclinical studies. Currently, there is no generally recognised and detailed approach to drug-induced nephrotoxicity detection in
Externí odkaz:
https://doaj.org/article/b88b40828e534149bc065f76e570bfcb
Publikováno v:
Translational Medicine. 9:44-77
Cytochrome P450 enzymes play a key role in drug biotransformation. The expression and activity of each CYP450 is influenced by a unique combination of biochemical factors, species and genetic differences, age, sex, nutrition and etc.Cytochromes P450
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e073578662e0090b3f4e86f7c236a119
https://doi.org/10.18705/2311-4495-2022-9-5-44-77
https://doi.org/10.18705/2311-4495-2022-9-5-44-77
Autor:
Maxim A. Kochergin, Alexander A. Spasov, D. V. Mal’tsev, D. S. Yakovlev, Maria O. Skripka, Lyudmila N. Divaeva, K. T. Sultanova, M. V. Miroshnikov
Publikováno v:
Research Results in Pharmacology 7(2): 31-37
Research Results in Pharmacology, Vol 7, Iss 2, Pp 31-37 (2021)
Research Results in Pharmacology, Vol 7, Iss 2, Pp 31-37 (2021)
Introduction: Searching for new compounds with anti-anxiety activity resulting from the combination of privileged scaffolds is a promising direction in medicinal chemistry and in the development of new drugs. Anxiolytic potential and cytotoxic proper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c391bad459285a929f28201d4a2c05f8
https://doi.org/10.3897/rrpharmacology.7.67499
https://doi.org/10.3897/rrpharmacology.7.67499
Publikováno v:
Russian Journal of Bioorganic Chemistry. 47:622-652
This article presents a review of studies of new pharmacological substances in the aspect of their anxiolytic activity. These substances are derivatives of various chemical classes. The variety of synthesized substances described in this article is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d06e5224c850956eb4737ed97526a729
https://doi.org/10.1134/s1068162021030122
https://doi.org/10.1134/s1068162021030122
Autor:
D. V. Maltsev, A. A Spasov, M. V. Miroshnikov, M. O. Skripka, Yu. Yu Dementenko, E. M Chernikova
Publikováno v:
Journal of Volgograd State Medical University. 18:131-136
For the substance under the code DAB-21, a pronounced neuropsychotropic potential was previously shown. In this study, possible directions of the influence of the studied substance on basic mediator systems of the CNS are considered. According to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b49a3f02716dbe740a3b51cef5bcc0a
https://doi.org/10.19163/1994-9480-2021-1(77)-131-136
https://doi.org/10.19163/1994-9480-2021-1(77)-131-136
Publikováno v:
Research Results in Pharmacology, Vol 6, Iss 3, Pp 9-14 (2020)
Research Results in Pharmacology 6(3): 9-14
Research Results in Pharmacology 6(3): 9-14
Introduction: Diazepino[1,2-a]benzimidazole derivatives showed anxiolytic (EPM, L/D box, Vogel test), antidepressant (Tail Suspension test, Porsolt test), anticonvulsant (Pentylenetetrazole-Induced seizures) and analgesic (Tail-Flick, Hot Plate) acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f68408dc9f5a29e6989c5d42ba16835a
https://rrpharmacology.pensoft.net/article/55142/download/pdf/
https://rrpharmacology.pensoft.net/article/55142/download/pdf/
Autor:
Alexander A. Spasov, S. K. Kotovskaya, Vladimir L. Rusinov, V. A. Kosolapov, K. T. Sultanova, M. V. Miroshnikov, Irina M. Sapozhnikova, D. V. Mal’tsev
Publikováno v:
Toxicological Review. :39-43
The article presents the results of a study of the neurotoxicological profile of the new compound AB-19, acting on collagen glycation end products (AGE) and their receptors (RAGE), for the prevention and treatment of diabetes complications. The multi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0af7f4e438104ac377f0130ea93333a
https://doi.org/10.36946/0869-7922-2020-4-39-43
https://doi.org/10.36946/0869-7922-2020-4-39-43
Autor:
Alexander A. Spasov, D. V. Mal’tsev, Anatolii S. Morkovnik, O. N. Zhukovskaya, K. T. Sultanova, M. V. Miroshnikov, Maria O. Skripka
Publikováno v:
Russian Journal of Bioorganic Chemistry. 46:107-114
This paper presents a study of the anxiolytic activity of compounds that belong to two classes of chemical groups: derivatives of 11H-2,3,4,5-tetrahydro[1,3]diazepino[1,2-a]benzimidazole (BIF) and derivatives of 2-mercaptobenzimidazole (AZH). The stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17c47aa6e10c169fe1ffcabed1c4546c
https://doi.org/10.1134/s1068162020010124
https://doi.org/10.1134/s1068162020010124
Autor:
Anatolii S. Morkovnik, D. V. Mal’tsev, Lyudmila N. Divaeva, Pavel M. Vassiliev, Alexander A. Spasov, Nataliya V Eliseeva, Tat’yana A. Kuz’menko, Maria O. Skripka, A. N. Kochetkov, M. V. Miroshnikov, Yuliya V. Lifanova
Publikováno v:
Molecules, Vol 26, Iss 6049, p 6049 (2021)
Molecules
Volume 26
Issue 19
Molecules
Volume 26
Issue 19
A number of novel 2,3,4,5-tetrahydro[1,3]diazepino[1,2-a]benzimidazole derivatives 2 were obtained by alkylation mainly in the 1H-tautomeric form of 2,3,4,5-tetrahydro[1,3]diazepino[1,2-a]benzimidazole or its 8,9-dimethyl-substituted analog 4-chlorob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec93f61f2cbe2b8c8000674e2469fa03
https://www.mdpi.com/1420-3049/26/19/6049
https://www.mdpi.com/1420-3049/26/19/6049