Zobrazeno 1 - 10
of 16
pro vyhledávání: '"M. V. Jasko"'
Publikováno v:
Molecular Biology. 55:624-636
Autor:
S. D. Negrya, M. V. Jasko, D. A. Makarov, P. N. Solyev, I. L. Karpenko, O. V. Shevchenko, O. V. Chekhov, A. A. Glukhova, B. F. Vasilyeva, T. A. Efimenko, I. G. Sumarukova, O. V. Efremenkova, S. N. Kochetkov, L. A. Alexandrova
Publikováno v:
Molecular Biology. 55:143-153
Publikováno v:
Molekuliarnaia biologiia. 55(4)
Hydrophobic molecules may be toxic when present in excess. When dissolved in membranes, hydrophobic molecules disrupt membrane function. Studies on the effects of free fatty acids (FFA) on cultured cells contradict each other. Here we describe the ef
Autor:
S D, Negrya, M V, Jasko, D A, Makarov, P N, Solyev, I L, Karpenko, O V, Shevchenko, O V, Chekhov, A A, Glukhova, B F, Vasilyeva, T A, Efimenko, I G, Sumarukova, O V, Efremenkova, S N, Kochetkov, L A, Alexandrova
Publikováno v:
Molekuliarnaia biologiia. 55(1)
Resistance developed to the majority of drugs used to treat infectious diseases warrants the design of new compounds effective against drug-resistant strains of pathogens. Recently, several groups of modified nucleosides have been synthesized and sho
Publikováno v:
Acta Naturae
As has been shown previously, phosphite of acycloguanosine (Hp-ACG) exhibits equal efficacy against ACV-sensitive and ACV-resistant HSV-1 strains in cell culture. Intraperitoneal administration of Hp-ACG to model mice with herpetic encephalitis cause
Publikováno v:
Russian Journal of Bioorganic Chemistry. 37:578-585
A series of new acyclovir phosphoramidates—potential antiviral agents against resistant strains of herpes virus—was synthesized. Of several approaches used for their synthesis, the treatment of the intermediate phosphorochloridate with various am
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 46:669-676
New approaches to the synthesis of 3′-azido-3′-deoxythymidine labelled with tritium in the heterocyclic base have been developed. With this aim, enzymatic transribosylation with [3H]thymine using the enzyme preparation from rat liver and a three-
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 50:585-587
Publikováno v:
ChemInform. 35
A new synthesis of chiral acyclic nucleoside and nucleotide analogues starting from d (−)- or l (+)-riboses was proposed. Antiviral properties of the synthesized compounds towards the pox virus family were evaluated.
Autor:
E. De Clercq, J.-L. Imbach, G. V. Gurskaya, J. Balzarini, M. V. Jasko, E. M. Kazmina, J.-P. Sommadossi, Abdesslem Faraj, I. Fedorov, V. E. Zavodnic, G. Gosselin
Publikováno v:
Journal of medicinal chemistry. 40(4)
A synthetic scheme for the 3'-oxime derivatives 3E, 5E, 5Z, 7E and 7Z of 1-(2,3-dideoxy-beta-D-glycero-pentofuranosyl)thymine and for 1-(2,3-dideoxy-3-nitro-beta-D-erythro-pentofuranosyl)-thymine (10) has been developed starting from appropriately 5'