Mre11 exonuclease activity removes the chain-terminating nucleoside analog gemcitabine from the nascent strand during DNA replication

Autor: B. Paizs, Edgar Hartsuiker, D. Chaplin, S. Gollins, L. Boeckemeier, Cathrine Broberg Vågbø, R. Beardmore, M. U. Gasasira, R. Kraehenbuehl, S. A. E. Lambert, Ellen G Vernon, A. Keszthelyi, Hans E. Krokan

Publikováno v: Science Advances
Science Advances, American Association for the Advancement of Science (AAAS), 2020, 6 (22), pp.eaaz4126. ⟨10.1126/sciadv.aaz4126⟩

Mre11 exonuclease activity removes gemcitabine from the nascent strand during DNA replication.
The Mre11 nuclease is involved in early responses to DNA damage, often mediated by its role in DNA end processing. MRE11 mutations and aberrant expres

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https://hal.archives-ouvertes.fr/hal-03008931/document