Zobrazeno 1 - 10
of 177
pro vyhledávání: '"M. Turci"'
Publikováno v:
The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, Vol XL-1-W2, Pp 5-10 (2013)
Volcanic activity has often affected human life both at large and at small scale. For example, the 2010 Eyjafjallajokull eruption caused severe economic damage at continental scale due to its strong effect on air traffic. At a local scale, ash fall
Externí odkaz:
https://doaj.org/article/999e0239cef9422db096025aa6d94521
Akademický článek
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Development of Novel Dual Binders as Potent, Selective, and Orally Bioavailable Tankyrase Inhibitors
Autor:
Zihao Hua, Bryan Egge, Erin L. Mullady, Hakan Gunaydin, John L. Buchanan, Steve Schneider, Xin Huang, Yohannes Teffera, Renee Emkey, Howard Bregman, Randy Serafino, Mary K. Stanton, Erin F. DiMauro, Jingzhou Liu, Virginia Berry, Douglas Saffran, Angel Guzman-Perez, Jennifer Dovey, Liyue Huang, Craig A. Strathdee, Susan M. Turci, Yan Gu, Paul S. Andrews, John Newcomb, Cindy Wilson, Ankita Mishra, Lisa Acquaviva, Nagasree Chakka
Publikováno v:
Journal of Medicinal Chemistry. 56:10003-10015
Tankyrases (TNKS1 and TNKS2) are proteins in the poly ADP-ribose polymerase (PARP) family. They have been shown to directly bind to axin proteins, which negatively regulate the Wnt pathway by promoting β-catenin degradation. Inhibition of tankyrases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eba595497eee0272affa9da310eb1804
https://doi.org/10.1021/jm401317z
https://doi.org/10.1021/jm401317z
Autor:
Angel Guzman-Perez, Erin L. Mullady, Randy Serafino, Erin F. DiMauro, Hakan Gunaydin, Xin Huang, Liyue Huang, Jingzhou Liu, Virginia Berry, Bryan Egge, Nagasree Chakka, Cindy Wilson, Steve Schneider, John Newcomb, Yan Gu, Yohannes Teffera, Susan M. Turci, Ankita Mishra, Paul S. Andrews, Howard Bregman, Craig A. Strathdee
Publikováno v:
Journal of Medicinal Chemistry. 56:4320-4342
Tankyrase (TNKS) is a poly-ADP-ribosylating protein (PARP) whose activity suppresses cellular axin protein levels and elevates β-catenin concentrations, resulting in increased oncogene expression. The inhibition of tankyrase (TNKS1 and 2) may reduce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a21eb09a2b123ca06a4a37ee2b8c466a
https://doi.org/10.1021/jm4000038
https://doi.org/10.1021/jm4000038
Autor:
Xin Huang, Susan M. Turci, Zihao Hua, Randy Serafino, Liyue Huang, Jin Tang, Jason Brooks Human, Ryan White, Lisa Acquaviva, Jennifer Dovey, Barbara Grubinska, Oleg Epstein, Doug Saffran, Huilin Zhao, Steve Schneider, Howard Bregman, Hongbing Huang, Anne B. O’Connor, Violeta Yu, John Newcomb, Jonathan T. Goldstein, Nagasree Chakka, Matthew W. Martin, Vinod F. Patel, Craig A. Strathdee, Virginia Berry, Alexander M. Long, Cindy Wilson, Erin F. DiMauro, Hakan Gunaydin
Publikováno v:
ACS Medicinal Chemistry Letters. 3:1059-1064
Aberrant activation of the Wnt pathway is believed to drive the development and growth of some cancers. The central role of CK1γ in Wnt signal transduction makes it an attractive target for the treatment of Wnt-pathway dependent cancers. We describe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc43848aa690914df587add69f5cd2c3
https://doi.org/10.1021/ml300278f
https://doi.org/10.1021/ml300278f
Akademický článek
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Autor:
Kurt Morgenstern, Matthew W. Martin, Faye Hsieh, Stuart C. Chaffee, Susan A. Tomlinson, Susan M. Turci, Joseph J. Nunes, Lilly Chai, Paul E. Rose, Josie H. Lee, Antonio J. Oliveira-dos-Santos, Erin F. DiMauro, Vinod F. Patel, David Powers, Yan Gu, Xin Huang, Jean Bemis, Andrew A. Welcher, David C. Mcgowan, Huilin Zhao, Joseph L. Kim, Xiaotian Zhu, Holly L. Deak, Li Zhu, Yanyan Tudor, Ted Faust, Linda F. Epstein, Christina Boucher, Anu Gore, Deanna Mohn, Stephen Schneider, John Newcomb, Daniela Metz, Brad Henkle, Paul Gallant
Publikováno v:
Journal of Medicinal Chemistry. 51:1681-1694
The lymphocyte-specific kinase (Lck), a member of the Src family of cytoplasmic tyrosine kinases, is expressed in T cells and natural killer (NK) cells. Genetic evidence, including knockout mice and human mutations, demonstrates that Lck kinase activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cea8884d0e69b4d85c6e3a74c4f98b0f
https://doi.org/10.1021/jm7010996
https://doi.org/10.1021/jm7010996
Autor:
Ryan White, David C. Mcgowan, Xiaotian Zhu, Matthew W. Martin, John Newcomb, John L. Buchanan, Theodore Faust, Faye Hsieh, Xin Huang, Erin F. DiMauro, Susan M. Turci, Christina Boucher, Stephen Schneider, Joseph J. Nunes, Jean Bemis, Josie H. Lee
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:2299-2304
2,3-Diarylfuro[2,3-b]pyridine-4-amines are a novel class of potent and selective inhibitors of Lck. The discovery, synthesis, and structure activity relationships of this series of inhibitors are reported. The most promising compounds were also profi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cec8aa93efe43539a086c398621a2de
https://doi.org/10.1016/j.bmcl.2007.01.048
https://doi.org/10.1016/j.bmcl.2007.01.048