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Akademický článek

Characteristics of women with ischemic sudden cardiac death

Autor: I. Hookana, L. Holmström, M. A. E. Eskuri, L. Pakanen, M. M. Ollila, A. M. Kiviniemi, T. Kenttä, J. Vähätalo, M. Tulppo, E. S. Lepojärvi, T. Piltonen, J. Perkiömäki, J. T. Tikkanen, H. V. Huikuri, M. J. Junttila

Publikováno v: Annals of Medicine, Vol 55, Iss 2 (2023)

AbstractBackground Sudden cardiac death (SCD) is a significant mode of death causing 15-20% of all deaths in high-income countries. Coronary artery disease (CAD) is the most common cause of SCD in both sexes, and SCD is often the first manifestation

Externí odkaz: https://doaj.org/article/abc305fcfd444e3680003e96da069051

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Serotonin agonists and antagonists. Pharmacological tools and therapeutics

Autor: I. Van Wijngaarden, W. Soudijn, M. Th. M. Tulp

Publikováno v: Recueil des Travaux Chimiques des Pays-Bas. 112:126-130

Medicinal chemists have provided crucial tools for the identification and characterization of various subtypes of serotonin (5-hydroxytryptamine, 5-HT) receptors. At present, potent and selective (ratio ≥ 100) ligands have been developed for the 5-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9c8a2def09640cccd09baf2f24c7c339
https://doi.org/10.1002/recl.19931120209

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ChemInform Abstract: Serotonin Agonists and Antagonists. Pharmacological Tools and Therapeutics

Autor: I. Van Wijngaarden, M. Th. M. Tulp, W. Soudijn

Publikováno v: ChemInform. 24

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ce522724514ea6d1eaf3eec7d8dfd0ee
https://doi.org/10.1002/chin.199331342

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ChemInform Abstract: Synthesis and Receptor-Affinity Profile of N-Hydroxytryptamine Derivatives for Serotonin and Tryptamine Receptors. A Molecular- Modeling Study

Autor: M. Th. M. Tulp, P. H. H. Hermkens, J. H. Van Maarseveen, H. W. Scheeren, C.G. Kruse, Gerard D. H. Dijkstra

Publikováno v: ChemInform. 24

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3cb35acff98423ec1c5b863c6f1fa298
https://doi.org/10.1002/chin.199331257

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ChemInform Abstract: A Series of N4-Imidoethyl Derivatives of 1-(2,3-Dihydro-1,4- benzodioxin-5-yl)piperazine as 5-HT1A Receptor Ligands: Synthesis and Structure-Affinity Relationships

Autor: M. Th. M. Tulp, B. J. Van Steen, I. Van Wijngaarden, W. Soudijn

Publikováno v: ChemInform. 27

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::88e8aa696c569cefdbc158eea6d2c8f3
https://doi.org/10.1002/chin.199607180

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Preclinical evidence for the role of serotonin receptor-subtypes in depression

Autor: J. Mos, Schipper Jacques, M. Th. M. Tulp, A. van Hest, B. Olivier, J.A.M. van der Heyden

Publikováno v: Acta Neuropsychiatrica. 4:40-45

SummarySerotonin (5-HT) plays an important role in depression and specific 5-HT reuptake blockers appear to be clinically important antidepressants. It is unclear however, which serotonergic mechanism is involved in the antidepressant effect, certain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::615095d01f54bf855b338b9fc88d1ffd
https://doi.org/10.1017/s0924270800034888

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Serotonergic receptors in anxiety and aggression; evidence from animal pharmacology

Autor: Jan Mos, M. Th. M. Tulp, Berend Olivier

Publikováno v: Human Psychopharmacology: Clinical and Experimental. 6:S73-S78

The present contribution describes the effects of 5-HT1A, 5-HT1B, 5-HT1C, 5-HT1D, 5-HT2 and 5-HT3 ligands in preclinical models of anxiety and aggression in rodents. 5-HT1A agonists show up as strong anxiolytic drugs in some animal paradigms, but not

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::728c42ddf1e94dd2f8fe448e5afd5a55
https://doi.org/10.1002/hup.470060511

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Preclinical pharmacology of flesinoxan: A potential anxiolytic and antidepressant drug

Autor: B. Olivier, M. Th. M. Tulp, J. Mos, Schipper Jacques, B. Berkelmans, J. A. M. van der Heijden

Publikováno v: Human Psychopharmacology: Clinical and Experimental. 6:S53-S61

Receptor binding studies revealed that flesinoxan potently and selectively binds to the 5-HT1A receptor (Ki = 1.7 nM). The anatomical distribution of [3H]-flesinoxan binding sites is very similar to the localization of the 5-HT1A sites labelled by [3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2ce9d32560e3107ca8c6d617f985e03c
https://doi.org/10.1002/hup.470060509

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