Zobrazeno 1 - 10
of 13
pro vyhledávání: '"M. Trent Kemp"'
Autor:
Michael D Sacco, Lauren R Hammond, Radwan E Noor, Dipanwita Bhattacharya, Lily J McKnight, Jesper J Madsen, Xiujun Zhang, Shane G Butler, M Trent Kemp, Aiden C Jaskolka-Brown, Sebastian J Khan, Ioannis Gelis, Prahathees Eswara, Yu Chen
Publikováno v:
eLife, Vol 13 (2024)
In the Firmicutes phylum, GpsB is a membrane associated protein that coordinates peptidoglycan synthesis with cell growth and division. Although GpsB has been studied in several bacteria, the structure, function, and interactome of Staphylococcus aur
Externí odkaz:
https://doaj.org/article/bfed07d8cbee49deab96202e09ac50e1
Autor:
Yu Chen, Adam R. Renslo, M. Trent Kemp, Insung Na, Xiujun Zhang, Kyle DeFrees, Derek A. Nichols
Publikováno v:
FEBS Letters. 595:2981-2994
The Asp233-Asp246 pair is highly conserved in Class A β-lactamases, which hydrolyze β-lactam antibiotics. Here, we characterize its function using CTX-M-14 β-lactamase. The D233N mutant displayed decreased activity that is substrate-dependent, wit
Autor:
Michael D. Sacco, Lauren R. Hammond, Radwan E. Noor, Dipanwita Bhattacharya, Jesper J. Madsen, Xiujun Zhang, Shane G. Butler, M. Trent Kemp, Aiden C. Jaskolka-Brown, Sebastian J. Khan, Ioannis Gelis, Prahathees J. Eswara, Yu Chen
Bacterial cell division is a tightly regulated process that requires the formation of a dynamic multi-protein complex. In the Firmicutes phylum, GpsB is a membrane associated protein that coordinates peptidoglycan synthesis for cell growth and divisi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c0c2d8b9c6e1d181b8709ade21ca036
https://doi.org/10.1101/2022.10.25.513704
https://doi.org/10.1101/2022.10.25.513704
Autor:
M V Vasantha Kumar, Radwan Ebna Noor, Ioannis Gelis, Ruslan Sanishvili, Orville A. Pemberton, H. Lee Woodcock, M. Trent Kemp, Yu Chen, Fiona L. Kearns
Publikováno v:
Proc Natl Acad Sci U S A
Gram-negative bacteria expressing class A β-lactamases pose a serious health threat due to their ability to inactivate all β-lactam antibiotics. The acyl–enzyme intermediate is a central milestone in the hydrolysis reaction catalyzed by these enz
Autor:
Xochina ElHilali-Pollard, Kyle DeFrees, Adam R. Renslo, Ahmed Mohamed, M. Trent Kemp, Yu Chen, Xiujun Zhang
Publikováno v:
Org Chem Front
Compared to aryl–aryl π-stacking interactions, the analogous stacking of heteroarenes on amide π systems is less well understood and vastly underutilized in structure-based drug design. Recent theoretical studies have delineated the important geo
Autor:
Roman Manetsch, Tommy W. McGaha, M. Trent Kemp, Niranjan K. Namelikonda, Randy W. Larsen, Dennis E. Kyle, Lynn D. Blake, Adonis McQueen, Ala Azhari
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:4597-4600
Primaquine (PQ) is the only commercially available drug that clears dormant liver stages of malaria and blocks transmission to mosquito vectors. Although an old drug, much remains to be known about the mechanism(s) of action. Herein we develop a fluo
Autor:
H. Lee Woodcock, Eric V. Anslyn, Fiona L. Kearns, Carrie Robart, Brette M. Chapin, M. Trent Kemp, Sai Lakshmana Vankayala, Joseph D. Larkin
Publikováno v:
Journal of chemical information and modeling, 2019, Vol.59(5), pp.2150-2158 [Peer Reviewed Journal]
J Chem Inf Model
J Chem Inf Model
Designing organic saccharide sensors for use in aqueous solution is a non-trivial endeavor. Incorporation of hydrogen bonding groups on a sensor’s receptor unit to target saccharides is an obvious strategy, but not one that is likely to ensure anal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5e5b8c45d507a8862122e020401e768
http://dro.dur.ac.uk/27761/1/27761.pdf
http://dro.dur.ac.uk/27761/1/27761.pdf
Publikováno v:
Biochim Biophys Acta Proteins Proteom
Low-barrier hydrogen bonds (LBHBs) are a special type of short hydrogen bond (HB) that is characterized by the equal sharing of a hydrogen atom. The existence and catalytic role of LBHBs in proteins has been intensely contested. Advancements in X-ray
Autor:
M. Trent Kemp, Aleksandra Karolak, Christi L. Whittington, H. Lee Woodcock, Tarah A. Word, Arjan van der Vaart, Randy W. Larsen
Publikováno v:
Chemical Physics Letters. 619:214-218
The thermodynamics of ligand photorelease from Ru(II)bis(2,2′-bipyridine)(6,6′-dimethyl-2,2′-bipyridine) ([Ru(bpy)2(dmbpy)]2+) complex in aqueous solution have been examined using photoacoustic calorimetry (PAC). Photolysis of the [Ru(bpy)2(dmb
Autor:
Francis C. Peterson, Amanda M. Nevins, Emmanuel W. Smith, Rongshi Li, Anthony E. Getschman, Brian F. Volkman, Yu Chen, M. Trent Kemp, Zhen Qiao, Yan Liu, Sai Lakshmana Vankayala
CXCL12 is a human chemokine that recognizes the CXCR4 receptor and is involved in immune responses and metastatic cancer. Interactions between CXCL12 and CXCR4 are an important drug target but, like other elongated protein-protein interfaces, present
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6f8774060ff6d2aacb6e76381d5f5cc
https://europepmc.org/articles/PMC5600900/
https://europepmc.org/articles/PMC5600900/