Zobrazeno 1 - 9
of 9
pro vyhledávání: '"M. Tobias Heinrichs"'
Autor:
Shixing Zhu, Jiayuan Zhang, Chu Song, Yuwei Liu, Charles Oo, M. Tobias Heinrichs, Zhihua Lv, Yuanqi Zhu, Sherwin K. B. Sy, Pan Deng, Mingming Yu
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
Empirical therapies using polymyxins combined with other antibiotics are recommended in the treatment of Acinetobacter baumannii infections. In the present study, the synergistic activities of polymyxin-B, meropenem, and sulbactam as combination ther
Externí odkaz:
https://doaj.org/article/ca87e4834fdb47e68fb88ec94c42675d
Publikováno v:
British Journal of Clinical Pharmacology. 87:1012-1023
Aims The objective of the current study was to evaluate paediatric dosing regimens for meropenem plus fosfomycin that generate sufficient coverage against multidrug-resistant bacteria. Methods The physiologically based pharmacokinetic (PBPK) models o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d25b46e64d311ec99a69c714cc1a3326
https://doi.org/10.1111/bcp.14456
https://doi.org/10.1111/bcp.14456
Autor:
Donna Griebel, Insook Kim, Robert M. Nelson, Jeremiah D. Momper, M. Tobias Heinrichs, Issam Zineh, Yeruk Mulugeta, Nitin Mehrotra, Shaun Kumar, Gregory H. Reaman, Vikram Sinha, Hari Cheryl Sachs, Narayana Garimella, Gilbert J. Burckart, Lynne Yao, Kevin Krudys, Andrew E. Mulberg
Publikováno v:
The Journal of Clinical Pharmacology. 60:775-784
Chemotherapy-induced nausea and vomiting (CINV) is a common treatment-related adverse event that negatively impacts the quality of life of cancer patients. During pediatric drug development, extrapolation of efficacy from adult to pediatric populatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ecc62c7baa425edbca6a89cf6b56d5f
https://doi.org/10.1002/jcph.1577
https://doi.org/10.1002/jcph.1577
Autor:
Nestani Tukvadze, Shota Gogishvili, Ketino Nikolaishvili, Hartmut Derendorf, Jeannette Guarner, Irina Sabulua, Russell R. Kempker, Brent P. Little, M. Tobias Heinrichs, Nino Bablishvili, Charles A. Peloquin, Adam Bernheim, Henry M. Blumberg, Sergo Vashakidze
Publikováno v:
Journal of Antimicrobial Chemotherapy. 73:477-483
Background Moxifloxacin is a second-line anti-TB drug that is useful in the treatment of drug-resistant TB. However, little is known about its target site pharmacokinetics. Lower drug concentrations at the infection site (i.e. in severe lung lesions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b49034db3dec6a5811db57f94b6c7cc4
https://doi.org/10.1093/jac/dkx421
https://doi.org/10.1093/jac/dkx421
Autor:
Charles A. Peloquin, Arnold Louie, Kenneth H. Rand, David L. Brown, George L. Drusano, Michael Maynard, M. Tobias Heinrichs, Sherwin K. B. Sy, Hartmut Derendorf
Publikováno v:
International journal of antimicrobial agents. 53(3)
Introduction There is an urgent need for new anti-tuberculosis (TB) drugs and optimization of current TB treatment. Moxifloxacin and linezolid are valuable options for the treatment of drug-resistant TB; however, it is crucial to find a dose at which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7299299d2ef4c2b93b0c061b12823276
https://pubmed.ncbi.nlm.nih.gov/30385322
https://pubmed.ncbi.nlm.nih.gov/30385322
Lung Tissue Concentrations of Pyrazinamide among Patients with Drug-Resistant Pulmonary Tuberculosis
Autor:
Irina Sabulua, Brent P. Little, Sergo Vashakidze, Russell R. Kempker, M. Tobias Heinrichs, Nino Bablishvili, Henry M. Blumberg, Shota Gogishvili, Nestani Tukvadze, Charles A. Peloquin, Zaza Avaliani, Hartmut Derendorf, Timothy D. Read, Adam Bernheim, Jeannette Guarner, Ketino Nikolaishvili
Publikováno v:
Antimicrobial Agents and Chemotherapy. 61
Improved knowledge regarding the tissue penetration of antituberculosis drugs may help optimize drug management. Patients with drug-resistant pulmonary tuberculosis undergoing adjunctive surgery were enrolled. Serial serum samples were collected, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::019e68b6d99c721f761ae37c89eacb8e
https://doi.org/10.1128/aac.00226-17
https://doi.org/10.1128/aac.00226-17
Autor:
Satyawan B. Jadhav, Amelia N. Deitchman, Vipada Khaowroongrueng, Hartmut Derendorf, M. Tobias Heinrichs
Publikováno v:
The AAPS journal. 19(2)
Adequate drug penetration to a site of infection is absolutely imperative to ensure sufficient antimicrobial treatment. Microdialysis is a minimally invasive, versatile technique, which can be used to study the penetration of an antiinfective agent i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4617540cf22bcc1b3678f90cc31e9bdc
https://pubmed.ncbi.nlm.nih.gov/27943149
https://pubmed.ncbi.nlm.nih.gov/27943149
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