Zobrazeno 1 - 10
of 464
pro vyhledávání: '"M. Tighe"'
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Abstract The provenance or origin of a soil sample is of interest in soil forensics, archaeology, and biosecurity. In all of these fields, highly specialized and often expensive analysis is usually combined with expert interpretation to estimate samp
Externí odkaz:
https://doaj.org/article/81c0194e82ea47a794556e7521c734ba
Autor:
Dominique Bollino, Kanwal Hameed, Anusha Bhat, Arveen Zarrabi, Andrea Casildo, Xinrong Ma, Kayla M Tighe, Brandon Carter-Cooper, Erin T. Strovel, Rena G. Lapidus, Ashkan Emadi
Publikováno v:
Cancer & Metabolism, Vol 12, Iss 1, Pp 1-12 (2024)
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease without meaningful therapeutic options beyond the first salvage therapy. Targeting PDAC metabolism through amino acid restriction has emerged as a promising new stra
Externí odkaz:
https://doaj.org/article/525655e9405e4d5485db4d740e853fe2
Autor:
Robert M. Tighe, Anastasiya Birukova, Yuryi Malakhau, Yoshihiko Kobayashi, Aaron T. Vose, Vidya Chandramohan, Jaime M. Cyphert-Daly, R. Ian Cumming, Helene Fradin Kirshner, Purushothama R. Tata, Jennifer L. Ingram, Michael D. Gunn, Loretta G. Que, Yen-Rei A. Yu
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionEnvironmental exposures and experimental manipulations can alter the ontogenetic composition of tissue-resident macrophages. However, the impact of these alterations on subsequent immune responses, particularly in allergic airway diseases
Externí odkaz:
https://doaj.org/article/58d830a0b7af4c4690d268b1d113ef6f
Autor:
Md Habibul Hasan Mazumder, Jasleen Gandhi, Nairrita Majumder, Lei Wang, Robert Ian Cumming, Sydney Stradtman, Murugesan Velayutham, Quincy A. Hathaway, Jonathan Shannahan, Gangqing Hu, Timothy R. Nurkiewicz, Robert M. Tighe, Eric E. Kelley, Salik Hussain
Publikováno v:
Particle and Fibre Toxicology, Vol 20, Iss 1, Pp 1-21 (2023)
Abstract Background Microbial dysbiosis is a potential mediator of air pollution-induced adverse outcomes. However, a systemic comparison of the lung and gut microbiome alterations and lung-gut axis following air pollution exposure is scant. In this
Externí odkaz:
https://doaj.org/article/e583f09a8a5a44668f3507be711a941b
Autor:
Nicholas L. Drury, Toriq Mustapha, Ross A. Shore, Jiayun Zhao, Gus A. Wright, Aline Rodrigues Hoffmann, Susanne U. Talcott, Annette Regan, Robert M. Tighe, Renyi Zhang, Natalie M. Johnson
Publikováno v:
Particle and Fibre Toxicology, Vol 20, Iss 1, Pp 1-11 (2023)
Abstract Background Interactions between air pollution and infectious agents are increasingly recognized and critical to identify, especially to protect vulnerable populations. Pregnancy represents a vulnerable period for influenza infection and air
Externí odkaz:
https://doaj.org/article/cb046ea972994521a1b861f9c86f1fc6
Autor:
Beilei Lei, Chaojian Wang, Kamie Snow, Murilo E. Graton, Robert M. Tighe, Ammon M. Fager, Maureane R. Hoffman, Paloma H. Giangrande, Francis J. Miller, Jr.
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 31, Iss , Pp 662-673 (2023)
Acute lung injury (ALI) is a syndrome of acute inflammation, barrier disruption, and hypoxemic respiratory failure associated with high morbidity and mortality. Diverse conditions lead to ALI, including inhalation of toxic substances, aspiration of g
Externí odkaz:
https://doaj.org/article/60455e7ecf584a589b079e930bb50ded
Autor:
Michael Macklin, Chelsea Thompson, Leticia Kawano-Dourado, Iazsmin Bauer Ventura, Camila Weschenfelder, Andrés Trostchansky, Aline Marcadenti, Robert M. Tighe
Publikováno v:
Cells, Vol 12, Iss 18, p 2206 (2023)
Adipose tissue has functions beyond its principal functions in energy storage, including endocrine and immune functions. When faced with a surplus of energy, the functions of adipose tissue expand by mechanisms that can be both adaptive and detriment
Externí odkaz:
https://doaj.org/article/76e5f07526d54caf9f6b0afc7475a6b7
Autor:
Jack T. Womble, Mark D. Ihrie, Victoria L. McQuade, Akhil Hegde, Matthew S. McCravy, Sanat Phatak, Robert M. Tighe, Loretta G. Que, David D’Alessio, Julia K. L. Walker, Jennifer L. Ingram
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
IntroductionAsthma is a chronic airway inflammatory disease marked by airway inflammation, remodeling and hyperresponsiveness to allergens. Allergic asthma is normally well controlled through the use of beta-2-adrenergic agonists and inhaled corticos
Externí odkaz:
https://doaj.org/article/6e084abe5e73419884bcfc812cf47edd
Autor:
Alexys, Monoson, Evangeline, Schott, Kerry, Ard, Brita, Kilburg-Basnyat, Robert M, Tighe, Sonal, Pannu, Kymberly M, Gowdy
Publikováno v:
Toxicological Sciences. 192:3-14
Air pollution levels across the globe continue to rise despite government regulations. The increase in global air pollution levels drives detrimental human health effects, including 7 million premature deaths every year. Many of these deaths are attr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3423045ac812543655717c6d22daa807
https://doi.org/10.1093/toxsci/kfad003
https://doi.org/10.1093/toxsci/kfad003
Autor:
Salik Hussain, Collin G Johnson, Joseph Sciurba, Xianglin Meng, Vandy P Stober, Caini Liu, Jaime M Cyphert-Daly, Katarzyna Bulek, Wen Qian, Alma Solis, Yosuke Sakamachi, Carol S Trempus, Jim J Aloor, Kym M Gowdy, W Michael Foster, John W Hollingsworth, Robert M Tighe, Xiaoxia Li, Michael B Fessler, Stavros Garantziotis
Publikováno v:
eLife, Vol 9 (2020)
Lung disease causes significant morbidity and mortality, and is exacerbated by environmental injury, for example through lipopolysaccharide (LPS) or ozone (O3). Toll-like receptors (TLRs) orchestrate immune responses to injury by recognizing pathogen
Externí odkaz:
https://doaj.org/article/e3dac700dd8e4f4eb86e206a0c3f77fa