Zobrazeno 1 - 10
of 131
pro vyhledávání: '"M. Theisohn"'
Autor:
M. Theisohn, Bernhard Roth, Fritz Hering, Wolf Kremer, Diana Borucki, Carsten Mueller, Christoph Huenseler
Publikováno v:
European Journal of Pediatrics. 167:867-872
Piritramide is a synthetic opioid commonly used in Germany and Austria for the analgesia of pediatric patients. Little pharmacokinetic and pharmacodynamic data for the pediatric population is available. The aim of this investigation was to gain pharm
Publikováno v:
European Journal of Clinical Pharmacology. 58:459-465
s Objectives. In cancer treatment, arterial blood flow reduction by embolization combined with intra-arterial chemotherapy may be advantageous by achieving high and prolonged drug concentrations in the tumor, and lower systemic drug exposure. The pha
Autor:
J.M. Schierholz, A.F.E. Rump, U. Börner, M. Theisohn, Wolfgang Klaus, Manfred Abel, Christoph Diefenbach, W. Buzello, W. Biederbick
Publikováno v:
General Pharmacology: The Vascular System. 32:65-69
1. Pseudocholinesterase (ChE) activity is a determinant of the elimination kinetics of several drugs used in anesthesia. The time course of ChE activity was investigated in 16 patients under-going cardiosurgery for a cardiopulmonary bypass (CPB) in n
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 698:261-267
An improved high-performance liquid chromatographic assay for the cytostatic drug mitomycin C in plasma is presented. The principal steps are precipitation of plasma proteins with acetonitrile, lyophilization of the supernatant and reversed-phase chr
Autor:
F. Hoffmann, M. Theisohn, W. Klaus, Christoph Diefenbach, R. Süverkrüp, Manfred Abel, E. Koundourakis
Publikováno v:
Clinical Drug Investigation. 12:188-197
The infusion velocity of the short-acting muscle relaxant atracurium has to be reduced during hypothermic cardiopulmonary bypass to maintain a moderate degree of muscle relaxation. In the present study the extent of neuromuscular blockade and the pla
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 685:315-322
An improved high-performance liquid chromatography assay for the three stereoisomers of the muscle relaxant mivacurium and its metabolites in plasma is presented. The principal steps in the assay are precipitation of plasma proteins by acetonitrile,
Autor:
M. Theisohn, Bernhard Roth, M. Günther, G. Sticht, H. Tegtmeyer-Metzdorf, H. A. Adams, U. Heinemann
Publikováno v:
European Journal of Pediatrics. 154:649-653
Non-ketotic hyperglycinaemia (NKH) is a severe seizure disorder associated with high glycine levels. Glycine is a major inhibitory neurotransmitter in the CNS, but has also modulating effects at one of the glutamate receptors, the N-methyl-d-aspartat
Autor:
M. Schüssler, Uwe Fricke, Wolfgang Klaus, A. Cordes, A.F.E. Rump, R. Ratke, M. Theisohn, R. Rösen, D. Acar
Publikováno v:
General Pharmacology: The Vascular System. 26:603-611
1. 1. The antiischemic properties of the flavonoids acetylvitexin-rhamnoside (AVR) and luteolin-7-glucoside-(LUT), combining phosphodiesterase (PDE)-inhibitory and antioxidant properties, were studied in comparison to amrinone (AMR) or superoxide dis
Publikováno v:
Journal of Ocular Pharmacology and Therapeutics. 11:49-55
To determine the intraocular concentrations of Mitomycin C (MMC) after extraocular application, we used pigmented rabbits and placed sponges soaked with MMC under the conjunctiva on top of the intact episclera. First, we soaked the sponges with volum
Publikováno v:
Mycoses. 49
Posaconazole is a new antifungal drug used in prophylaxis and therapy of fungal infections in patients with immunodeficiency. In the clinical development, posaconazole exhibits variable oral bioavailability. Hence drug monitoring is recommended. For