Zobrazeno 1 - 10
of 15
pro vyhledávání: '"M. Th M. Tulp"'
Publikováno v:
Recueil des Travaux Chimiques des Pays-Bas. 112:126-130
Medicinal chemists have provided crucial tools for the identification and characterization of various subtypes of serotonin (5-hydroxytryptamine, 5-HT) receptors. At present, potent and selective (ratio ≥ 100) ligands have been developed for the 5-
Publikováno v:
ChemInform. 24
Medicinal chemists have provided crucial tools for the identification and characterization of various subtypes of serotonin (5-hydroxytryptamine, 5-HT) receptors. At present, potent and selective (ratio ≥ 100) ligands have been developed for the 5-
Autor:
M. Th. M. Tulp, P. H. H. Hermkens, J. H. Van Maarseveen, H. W. Scheeren, C.G. Kruse, Gerard D. H. Dijkstra
Publikováno v:
ChemInform. 24
Publikováno v:
ChemInform. 27
Publikováno v:
Acta Neuropsychiatrica. 4:40-45
SummarySerotonin (5-HT) plays an important role in depression and specific 5-HT reuptake blockers appear to be clinically important antidepressants. It is unclear however, which serotonergic mechanism is involved in the antidepressant effect, certain
Publikováno v:
Human Psychopharmacology: Clinical and Experimental. 6:S73-S78
The present contribution describes the effects of 5-HT1A, 5-HT1B, 5-HT1C, 5-HT1D, 5-HT2 and 5-HT3 ligands in preclinical models of anxiety and aggression in rodents. 5-HT1A agonists show up as strong anxiolytic drugs in some animal paradigms, but not
Autor:
B. Olivier, M. Th. M. Tulp, J. Mos, Schipper Jacques, B. Berkelmans, J. A. M. van der Heijden
Publikováno v:
Human Psychopharmacology: Clinical and Experimental. 6:S53-S61
Receptor binding studies revealed that flesinoxan potently and selectively binds to the 5-HT1A receptor (Ki = 1.7 nM). The anatomical distribution of [3H]-flesinoxan binding sites is very similar to the localization of the 5-HT1A sites labelled by [3
Autor:
M Th M, Tulp
Publikováno v:
Tijdschrift voor diergeneeskunde. 127(12)
Publisher Summary For 5-HT1A receptors, many potent and selective ligands belonging to different chemical classes such as aminotetralins, indolylalkylamines, ergolines, aporphines, arylpiperazines, and aryloxyalkylamines are available. The majority o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13be28cab5e28f3ab0f4ca7f65381e3a
https://doi.org/10.1016/s0165-7208(97)80003-7
https://doi.org/10.1016/s0165-7208(97)80003-7
Publikováno v:
European journal of pharmacology. 188(6)
Since the demonstration that serotonin (5-hydroxytryptamine, 5-HT) interacts with different (sub)types of membrane receptors, several compounds have been proposed as potent and selective ligands for one of these 5-HT subtypes. Unfortunately, specific