Phenotypic Modulation of Cultured Primary Human Aortic Vascular Smooth Muscle Cells by Uremic Serum

Autor: Violeta Cazaña-Pérez, Pilar Cidad, Javier Donate-Correa, Ernesto Martín-Núñez, José R. López-López, M. Teresa Pérez-García, Teresa Giraldez, Juan F. Navarro-González, Diego Alvarez de la Rosa

Publikováno v: Frontiers in Physiology, Vol 9 (2018)

Patients with chronic kidney disease (CKD) have a markedly increased incidence of cardiovascular disease (CVD). The high concentration of circulating uremic toxins and alterations in mineral metabolism and hormone levels produce vascular wall remodel

Externí odkaz: https://doaj.org/article/aef3796622fb4390b85161f40a074f7c

miR-126 contributes to the epigenetic signature of diabetic vascular smooth muscle and enhances antirestenosis effects of Kv1.3 blockers

Autor: José R. López-López, Pilar Cidad, Mirella Fernández, Sebastian Albinsson, Sara Moreno-Estar, M. Teresa Pérez-García, Irene Cózar-Castellano, Marycarmen Arévalo-Martínez

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
UVaDOC. Repositorio Documental de la Universidad de Valladolid
Molecular Metabolism, Vol 53, Iss, Pp 101306-(2021)
Molecular Metabolism

Producción Científica
Objectives: Restenosis after vessel angioplasty due to dedifferentiation of the vascular smooth muscle cells (VSMCs) limits the success of surgical treatment of vascular occlusions. Type 2 diabetes (T2DM) has a major impa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cbcc347fd83fc9d342ee5c3f4b295be
http://hdl.handle.net/10261/260813

Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation

Autor: Miguel Angel de la Fuente, Enrique Calvo, Esperanza Alonso, José R. López-López, Pilar Cidad, Marycarmen Arévalo-Martínez, M. Teresa Pérez-García

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

The voltage-dependent potassium channel Kv1.3 has been implicated in proliferation in many cell types, based on the observation that Kv1.3 blockers inhibited proliferation. By modulating membrane potential, cell volume, and/or Ca2+ influx, K+ channel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3d494a1663e25328a29f1175ccb7ada
https://pubmed.ncbi.nlm.nih.gov/33230847

Myocardin-Dependent Kv1.5 Channel Expression Prevents Phenotypic Modulation of Human Vessels in Organ Culture

Autor: Pilar Cidad, Mirella Fernández, Sara Moreno-Estar, M. Teresa Pérez-García, Miguel Angel de la Fuente, José R. López-López, Nadia García-Mateo, Julia Serna, Marycarmen Arévalo-Martínez, María Simarro, Karl Swärd

Publikováno v: UVaDOC. Repositorio Documental de la Universidad de Valladolid
instname
Arterioscler Thromb Vasc Biol
Digital.CSIC. Repositorio Institucional del CSIC

[Objective]: We have previously described that changes in the expression of Kv channels associate to phenotypic modulation (PM), so that Kv1.3/Kv1.5 ratio is a landmark of vascular smooth muscle cells phenotype. Moreover, we demonstrated that the Kv1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfc9ff8ee5dda5e54c4f9a96b24c77fd
https://doi.org/10.1161/atvbaha.119.313492

The secret life of ion channels: Kv1.3 potassium channels and proliferation

Autor: M. Teresa Pérez-García, Pilar Cidad, José R. López-López

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

Kv1.3 channels are involved in the switch to proliferation of normally quiescent cells, being implicated in the control of cell cycle in many different cell types and in many different ways. They modulate membrane potential controlling K+ fluxes, sen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9af58810dc1fca93f8a7b4087499a86e
https://pubmed.ncbi.nlm.nih.gov/28931540