Zobrazeno 1 - 10
of 126
pro vyhledávání: '"M. Teresa García-López"'
Publikováno v:
Molecules, Vol 19, Iss 4, Pp 4814-4846 (2014)
A series of Phe-Gly dipeptide-derived piperazinones containing an aromatic urea moiety and a basic amino acid has been synthesized and evaluated as inhibitors of human platelet aggregation induced by the PAR1 agonist SFLLRN and as cytotoxic agents in
Externí odkaz:
https://doaj.org/article/3c3b1dc427dc4d95b181225eb599692c
Publikováno v:
ARKIVOC, Vol 2008, Iss 17, Pp 287-294 (2009)
Externí odkaz:
https://doaj.org/article/6e8149501e204bd896a1ed44a6872526
Autor:
M. Teresa Garcia-Lopez, M. Socorro Serrano, Boris X. Camiletti, Ana Gordon, Cristina Estudillo, Antonio Trapero, Concepcion M. Diez, Juan Moral
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Olive anthracnose, a critical olive fruit disease that adversely impacts oil quality, is caused by Colletotrichum species. A dominant Colletotrichum species and several secondary species have been identified in each olive-growing region. Thi
Externí odkaz:
https://doaj.org/article/10382c75f5844ac18f0e7f2651f620eb
Autor:
M. Teresa García-López, Pilar Ventosa-Andrés, Nikos E. Tsopanoglou, Rosario Herranz, Ioannis Pappos, Ángel M. Valdivielso
Publikováno v:
European Journal of Medicinal Chemistry. 58:98-111
By applying a diversity oriented synthesis strategy for the search of new antagonists of the thrombin receptor PAR1, a series of peptide-based ureas and thioureas, including analogues of the PAR1 reference antagonist RWJ-58259, has been designed and
Synthesis and Regioselective Functionalization of Piperazin-2-ones Based on Phe-Gly Pseudodipeptides
Autor:
M. Teresa García-López, Ángel M. Valdivielso, Pilar Ventosa-Andrés, Marta Gutiérrez-Rodríguez, Rosario Herranz
Publikováno v:
European Journal of Organic Chemistry. 2013:155-161
The synthesis of 1,4-unsubstituted piperazin-2-ones by one-pot reductive cyclization of PheΨ[CH(CN)NH]Gly pseudodipeptides is described. Studies on the reactivity of the piperazin-2-one ring showed a higher reactivity at the N4 position than at the
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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Diverse basic amino acid-derived α-amino nitriles have been synthesized via a modified Strecker reaction, using TMSCN as the cyanide source. It has been found that this synthesis is a slow thermodynamically controlled reaction, where it was difficul
Autor:
M. Angeles Jiménez, Mercedes Martín-Martínez, Samie R. Jaffrey, Rosario González-Muñiz, Clara M. Santiveri, David Andreu, Beatriz G. de la Torre, M. Teresa García-López, Ramiro D. Almeida, Guillermo Gerona-Navarro, José Luis Baeza
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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Based on β-turn-like BDNF loops 2 and 4, involved in receptor interaction, cyclic peptide replicas were designed, synthesized and tested. In addition to the native turn residues, the cyclic peptides include a linker unit between the N- and C-termini
Autor:
Guillermo Gerona-Navarro, José Luis Baeza, M. Jesús Pérez de Vega, M. Teresa García-López, Mercedes Martín-Martínez, Lourdes Infantes, Kevin Thompson, Rosario González-Muñiz
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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9 pags, 5 figs, 1 tab. -- Supporting Information is available at the Publisher's web
(Chemical Equation Presented) Reverse turns, a common motif in proteins and peptides, have attracted attention due to their relevance in a wide variety of biolo
(Chemical Equation Presented) Reverse turns, a common motif in proteins and peptides, have attracted attention due to their relevance in a wide variety of biolo
Autor:
M. Teresa García-López, Rosario González-Muñiz, M. Isabel Garcia‐Aranda, M. Jesús Pérez de Vega
Publikováno v:
European Journal of Organic Chemistry. 2009:4149-4157
Experiments have been performed to prove the applicability and efficacy of 2-nitrobenzenesulfonohydrazide in the on-resin reduction of C=C double bonds of peptide derivatives. The method is useful for the two solid-phase peptide synthesis strategies,
Publikováno v:
ARKIVOC, Vol 2008, Iss 17, Pp 287-294 (2009)
A significant improvement on the synthesis of the PAR-1 antagonist RWJ-58259 is described, which involves a base-related two-fold yield increase in the indazole N-alkylation, and an easier purification and a nine-fold yield increase in the urea forma