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Akademický článek

Dehydroepiandrosterone reduces expression and activity of BACE in NT2 neurons exposed to oxidative stress

Autor: E Tamagno, M Guglielmotto, P Bardini, G Santoro, A Davit, D Di Simone, O Danni, M Tabaton

Publikováno v: Neurobiology of Disease, Vol 14, Iss 2, Pp 291-301 (2003)

Recently, we showed that oxidative stress activates the expression and activity of the β-site AβPP-cleaving enzyme (BACE), an aspartyl protease responsible for the β-secretase cleavage of AβPP. The identification of compounds able to prevent the

Externí odkaz: https://doaj.org/article/b0ba842579aa45bca8f2083c0228567a

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The molecular link between β- and γ-secretase activity on the amyloid β precursor protein

Autor: M. Tabaton, E. Tamagno

Publikováno v: Cellular and Molecular Life Sciences. 64:2211-2218

Alzheimer’s disease (AD) is characterized by an accumulation in the brain of amyloid β peptides (Aβ). The production of Aβ requires two sequential cleavages induced by β- and γ-secretases on the β-amyloid precursor protein (APP). Altered acti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::984539c542fe0b304a02b4c9e7f10a94
https://doi.org/10.1007/s00018-007-7219-3

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Instrumentation Note: A SIMPLE, INEXPENSIVE, AND PRECISE SPECTROPHOTOMETRIC METHOD FOR EVALUATING THE CONCENTRATION OF ASCORBIC ACID IN CSF SAMPLES: DATA FROM DIFFERENT NEUROLOGICAL PATHOLOGIES

Autor: Aroldo Cupello, M V Rapallino, G L Lunardi, M Tabaton

Publikováno v: International Journal of Neuroscience. 112:1337-1345

A method is presented for evaluating the concentration of ascorbic acid in 10 microliters samples of cerebrospinal fluid (CSF) with just ultraviolet (UV) scanning in the 220-300 nm range. The method assumes that the two main UV absorbing CSF componen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::552ad37aa034f0bdebaf582931d77d4b
https://doi.org/10.1080/00207450290158232

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Beta-amyloid is different in normal aging and in Alzheimer disease

Autor: Angela Bachi, Pierluigi Gambetti, Andrea Armirotti, Claudio Canale, Roberta Borghi, William R. Markesbery, Alessandra Gliozzi, Alessandra Piccini, Cristina D'Arrigo, Angela Cattaneo, M. Tabaton, Luca Giliberto, Antonella Vitali, Claudio Russo, Silvia Torrassa, Annalisa Relini, Takaomi C. Saido

Publikováno v: The Journal of biological chemistry
280 (2005): 34186–34192. doi:10.1074/jbc.M501694200
info:cnr-pdr/source/autori:Piccini A.; Russo C.; Gliozzi A.; Relini A.; Vitali A.; Borghi R.; Giliberto L.; Armirotti A.; D'Arrigo C.; Bachi A.; Cattaneo A.; Canale C.; Torrassa S.; Saido TC.; Markesbery W.; Gambetti P.; Tabaton M./titolo:Beta-amyloid is different in normal aging and in Alzheimer disease/doi:10.1074%2Fjbc.M501694200/rivista:The Journal of biological chemistry (Print)/anno:2005/pagina_da:34186/pagina_a:34192/intervallo_pagine:34186–34192/volume:280

The mechanism of neurodegeneration caused by beta-amyloid in Alzheimer disease is controversial. Neuronal toxicity is exerted mostly by various species of soluble beta-amyloid oligomers that differ in their N- and C-terminal domains. However, abundan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4571ac54a1ed9d909944ae6b44df748
http://www.jbc.org/content/280/40/34186

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Dehydroepiandrosterone reduces expression and activity of BACE in NT2 neurons exposed to oxidative stress

Autor: M Guglielmotto, M Tabaton, E Tamagno, O Danni, P Bardini, D Di Simone, G Santoro, Annalisa Davit

Publikováno v: Neurobiology of Disease, Vol 14, Iss 2, Pp 291-301 (2003)

Recently, we showed that oxidative stress activates the expression and activity of the beta-site AbetaPP-cleaving enzyme (BACE), an aspartyl protease responsible for the beta-secretase cleavage of AbetaPP. The identification of compounds able to prev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5161eb953c15730e2978f53a16bfda5f
http://hdl.handle.net/11567/251086

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Presenilin-1 mutations in Alzheimer's disease

Autor: Carol F. Lippa, Pierluigi Gambetti, Claudio Russo, Bernardino Ghetti, Gennaro Schettini, Christine M. Hulette, Takaomi C. Saido, Jan K. Teller, Lars Lannfelt, M. Tabaton

Publikováno v: Nature. 405(6786)

Mutations in the gene encoding the protein presenilin-1 are the most common cause of familial Alzheimer's disease1 and they often produce a different disease course from sporadic Alzheimer's and another familial form associated with mutations in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ff6c276b0d5114702ccbccaac5cd664
https://pubmed.ncbi.nlm.nih.gov/11395757

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Research advances in the biology of Alzheimer's disease

Autor: M, Tabaton

Publikováno v: Clinics in geriatric medicine. 10(2)

Research on AD has shed light on the biochemical composition and mechanisms of the formation of amyloid deposits and PHFs, the structural hallmarks of the disease. Amyloid is composed of a 4-kd peptide, beta P, that originates in the metabolism of a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::29a5b22d076fa25694987b5f3c97d260
https://pubmed.ncbi.nlm.nih.gov/8039097

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Beta protein immunoreactivity is found in the majority of neurofibrillary tangles of Alzheimer's disease

Autor: G, Perry, P, Cras, S L, Siedlak, M, Tabaton, M, Kawai

Publikováno v: The American journal of pathology. 140(2)

The presence of dystrophic neurites in most extracellular neurofibrillary tangles (E-NFT) suggests a factor promoting neurite growth in E-NFT. Although the beta-protein detected in E-NFT may fill that role, reports that only 2-10% of E-NFT contain be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::47de1accd7ca0124820c44c1aee83eea
https://pubmed.ncbi.nlm.nih.gov/1739122

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