Whole genome and transcriptome integrated analyses guide clinical care of pediatric poor prognosis cancers

Autor: Rebecca J. Deyell, Yaoqing Shen, Emma Titmuss, Katherine Dixon, Laura M. Williamson, Erin Pleasance, Jessica M. T. Nelson, Sanna Abbasi, Martin Krzywinski, Linlea Armstrong, Melika Bonakdar, Carolyn Ch’ng, Eric Chuah, Chris Dunham, Alexandra Fok, Martin Jones, Anna F. Lee, Yussanne Ma, Richard A. Moore, Andrew J. Mungall, Karen L. Mungall, Paul C. Rogers, Kasmintan A. Schrader, Alice Virani, Kathleen Wee, Sean S. Young, Yongjun Zhao, Steven J. M. Jones, Janessa Laskin, Marco A. Marra, Shahrad R. Rassekh

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)

Abstract The role for routine whole genome and transcriptome analysis (WGTA) for poor prognosis pediatric cancers remains undetermined. Here, we characterize somatic mutations, structural rearrangements, copy number variants, gene expression, immuno-

Externí odkaz: https://doaj.org/article/7e4974acf7f14999a67996f77a1aac77

Using a Novel Microfabricated Model of the Alveolar-Capillary Barrier to Investigate the Effect of Matrix Structure on Atelectrauma

Autor: Joshua A. Englert, Natalia Higuita-Castro, Samir N. Ghadiali, Wenjuan Zhang, Silvia Duarte-Sanmiguel, P. A. Agudelo-Garcia, Vasudha C. Shukla, M. T. Nelson, John J. Lannutti, Derek J. Hansford

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Scientific Reports

The alveolar-capillary barrier is composed of epithelial and endothelial cells interacting across a fibrous extracelluar matrix (ECM). Although remodeling of the ECM occurs during several lung disorders, it is not known how fiber structure and mechan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9ae6fca905e17f2ad8e2a3183acfccc
http://link.springer.com/article/10.1038/s41598-017-12044-9

Abstract A190: Management of germline findings revealed throughout the course of tumor-normal whole genome sequencing in oncology

Autor: Janessa Laskin, Aly Karsan, Shahrad Rassekh, Jessica M T Nelson, Sean D. Young, Yaoqing Shen, Robyn Roscoe, Stephen Yip, Alexandra Fok, Martin K. Jones, Howard John Lim, Alice Virani, Linlea Armstrong, Kasmintan A. Schrader, Erin Pleasance, Marco A. Marra, Rebecca Deyell

Publikováno v: Molecular Cancer Therapeutics. 17:A190-A190

Background: The Personalized OncoGenomics (POG) project at the BC Cancer Agency utilizes tumor-normal whole genome sequencing (WGS) to understand key driver pathways and guide personalized treatment decisions. Analysis of the germline data can reveal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ed408d6f88ac6b978c6c3566d7e05d16
https://doi.org/10.1158/1535-7163.targ-17-a190

Disruption of gallbladder smooth muscle function is an early feature in the development of cholesterol gallstone disease

Autor: B, Lavoie, B, Nausch, E A, Zane, M R, Leonard, O B, Balemba, A C, Bartoo, R, Wilcox, M T, Nelson, M C, Carey, G M, Mawe

Publikováno v: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 24(7)

BACKGROUND; Decreased gallbladder smooth muscle (GBSM) contractility is a hallmark of cholesterol gallstone disease, but the interrelationship between lithogenicity, biliary stasis, and inflammation are poorly understood. We studied a mouse model of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fb9af62f0e8ae891e1e6143003a31461
https://pubmed.ncbi.nlm.nih.gov/22621672

1992 Scientific Session of the Society of American Gastrointestinal Surgeons (SAGES) Washington, D.C., USA, April 11–12, 1992

Autor: Luigi Masoni, G. R. Orangio, B. Detroz, G. Meiser, Ingram, M. T. Nelson, Phillip Donahue, D. Johnson, Hideki Abe, L. E. Smith, J. Dubuc, R. H. Furman, Kenneth Adashek, Charles Aprahamian, J. Mamazza, Bruce M. Wolfe, R. Welling, Takashi Kusaka, F. Lehofer, S. M. Krishnan, R. Doerr, J. L. Flowers, R. C. W. Bell, Bruce D. Schirmer, J. L. Meakins, Donald L. Kaminski, Mary E. Front, Nicholas P. W. Coe, P. Honore, Christopher J. Saunders, R. Berguer, Harold Unger, C. F. Frey, M. A. Mansour, Timothy J. Pritchard, Kajiwara Shuji, E. J. Hinchey, Z. Szabo, John M. Cosgrove, I. Simon, Harrison Mr, Richard A. Kozarek, James M. Becker, Joseph J. Pietrafitta, Deanna L. Dunnegan, B. Murphy, B. J. Carroll, R. de la Torre, Ken-ichiro Hayashi, Streck, Kouji Miura, James W. Fleshman, W. L. Ambroze, Angel Escudero-Fabre, Newman, M. Kulaylat, M. S. Lucia, Mark D. Williams, Edward J. Quebbeman, N. Jacquet, L. Nathanson, M. Aguilar, Edward M. Phillips, Paul P. Priebe, G. W. Lucas, Yoichi Ishizaki, David M. Kam, L. C. Rusin, Jeffrey H. Peters, R. Satava, Edward S. Kondi, V. J. Lobbato, Mark A. Davanzo, J. Canady, T. R. Scott, Kimberly Ann Hobday, Bowman, J. Hill, George Berci, E. Nicolo, W. Cheadle, David S. Edleman, Charles E. Lucas, Samuel K. Snyder, J. G. Hunter, Dennis L. Fowler, P. Schlesinger, J. Brandabur, W. A. Scovill, Y. Fujiyama, Peter C. Murr, Jonathan M. Sackier, Zoltan Szabo, David L. Carr-Locke, Edgar D. Staren, Hiroyuki Kimata, Gerald M. Larson, Matt B. Martin, R. C. Thirlby, Y. Oba, D. H. Wittmann, D. J. Patterson, D. Baird, M. J. Fallas, David C. Brooks, Irving B. Margolis, D. P. Fletcher, Donald W. Weaver, Michael F. McGrath, R. Ghobrial, F. Nezhat, Richard C. Frazee, Farley, Robert G. Molnar, Davis, Toshihiko Yasuda, K. A. Zucker, Dido Franceschi, John N. Graber, James M. Church, J. Dix, M. Lavelle-Jones, J. Kim, Shinichi Hashimoto, P. C. Jolly, D. S. Edelman, Lee L. Swanstrom, John D. Corbitt, N. Keiter, Young, Albert Wetter, C. Gallagher, Hashimoto Daijo, Steven G. Economou, P. F. Leahy, Keith W. Millikan, J. Downey, M. Yamamoto, Frank B. Miller, M. Moriyama, Harvey H. Sigman, H. Leigh, Lloyd M. Nyhus, L. Daykhovsky, Debra L. Sudan, Fred A. Luchette, H. S. Himal, J. A. Hunter, J. McQueen, Charles H. Andrus, Norman B. Halpern, J. P. Andrus, Ballen, Mark Catalano, Michael A. Polacek, Keith N. Apelgren, O. Boeckl, K. Grannan, Barry Salky, Route G. Miscusi, Leonard S. Schultz, Hoshino Takanobu, Abrams, David Ollila, Gary C. Vitale, Yasuhiro Munakata, M. L. Eckhauser, Mark R. Borowicz, Stephen J. Shapiro, Masatoshi Makuuchi, Nichols, Robert J. Brodish, Blievernicht, S. W. Unger, D E Scheeres, James G. Tyburski, John G. Hunter, M. Castellano, Yasutsugu Bandai, R. Dewitty, Hideo Nagai, Christopher P. Brandt, Jonathan Sack, Marc L. Eckhauser, Sean J. Mulvihill, David B. Adams, Mathew R. Williams, J. A. Ryan, T. J. Ball, David R. Fletcher, Jack M. Bergstein, Shin-ei Kudo, M. Herndon, Choichi Sugawa, Gerald M. Fried, William Sangster, G. V. Stiegmann, Lindsey, Marcello Gasparrini, E. Christopher Ellison, John D. Mellinger, Leone, Jeffrey S. Bender, E. M. Elmann, Michael R. Treat, Michel Gagner, David F. Hickok, G. Orangio, Kouji Nakajima, Sidney F. Miller, Gregory V. Stiegmann, Seiji Kawasaki, Lawrence W. Way, Steven K. Libutti, Brock M. Bordelon, David Bouwman, Seigo Kitano, Joel J. Bauer, Leon Daykhovsky, K. Kelly, Bruce A. Orkin, C. Jagdeo, Kogoro Kasahara, K. Anan, R. M. Stephan, Hoxworth, O. Miho, J. Garzon, Horace F. Henriques, L. W. Traverso, J. Sun, John M. Kisala, K. Hashiba, W. C. Cirocco, Yukio Takano, Kazuyuki Shimomura, G. Berci, T. A. Meininger, T. A. Wierson, R. E. Schmieg, W. Voight, Weatherly, P. Green, Randall W. Smith, K. Sugimachi, Leo A. Gordon, Gregory E. Gibbons, A. Montori, D. G. Wechter, L. Michael Brunt, J. Osachoff, William O. Richards, M. Numata, R. P. Pennino, Isaac Raijman, G. W. Lexer, John T. Cunningham, Alfred Cuschieri, B. F. Leary, Unger Sw, G. Ch. Lexer, Daniel J. Deziel, E. Kieth, Jeffrey Barkun, B. Gardiner, P. M. Y. Goh, F. Fontana, H. Zinnecker, K. Sluss, Mark A. Talamini, D. Church, Barry N. Haicken, D. Congreve, Price, John C. Hendricks, M. Nakashima, Yasuo Kondo, Arkin, C. Nezhat, Stephen A. Shoop, Jonathan B. Lamphier, J. G. Tucker, S. Miller, Margaret Paz-Partlow, Sharon A. White, Marc Bessler, Catherine M. Wittgen, Tamaki Noie, Tsuneo Fukuyo, M. Legrand, Mark E. Stoker, Kyotaro Kanazawa, Nathaniel J. Soper, Yasuo Idezuki, Bruce V. MacFadyen, M. J. Wexler, R. Pons, Jeffrey T. Innes, David W. Easter, S. A. Nayeem, J. M. Sackier, Douglas O. Olsen, James M. Estes, Diflo T, Howard Franklin, William P. Reed, Richard Symmonds, John W. Roberts, H. M. Unger, Nadler, D. Seone, F. T. Wootton, B. Attar, I. A. Mustafa, M. Rheault, G. Rosenbaum, R. W. Bailey, A. L. De Paula, John Miller, J. Durham, Pamela J. Connors, Yumiko Ohtomo, Yasuhiko Hashikura, J. L. Meakin, J. Lohmuller, S. M. Graham, D. Litwin, A. L. Imbembo

Publikováno v: Surgical Endoscopy. 6:85-110

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5177134c54211dd7071b4ee2e1d0408a
https://doi.org/10.1007/bf02281090